Comparison of the effects of intravenous fluids and vasoconstrictive agents on the hemodynamic response developing in spinal anaesthesia

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dc.contributor.authorKaplan, Kemal
dc.contributor.authorGültekin, Yıldırım
dc.contributor.authorTanriverdi, Belkis
dc.date.accessioned2025-01-21T16:15:40Z
dc.date.available2025-01-21T16:15:40Z
dc.date.issued2021
dc.departmentKırıkkale Üniversitesi
dc.description.abstractAim: The study’s aim was to compare the effects of norepinephrine, ephedrine, and 0.9% sodium chloride (NaCl) solution against the hemodynamic response that develops after spinal anaesthesia. Materials and Methods: The study was conducted on 80 patients who were scheduled for surgery onlower extremity varicose veins, and they were divided into four groups. Group F was started with a 0.9% NaCl solution of 15ml/kg 20 minutes before spinal anaesthesia. For 20 minutes after spinal anaesthesia, Group E received 2mg/min of ephedrine and Group N received 5mic/min norepinephrine as an infusion. Meanwhile, Group C was not given any medication or fluid. Spinal anaesthesia was performed with 0.5% bupivacaine. The systolic blood pressure (SBP), diastolic blood pressure (DBP), heart rate (HR), and peripheral oxygen saturation (SPO2) values of the patients were recorded before and after the procedure. Sensorial block levels and degrees of motor block were also recorded after the operation. In addition, side effects other than hypotension that may develop after the surgery were also recorded. Results: There was no statistically significant difference between the groups in terms of SBP, DBP, SPO2, HR, sensory block level, and degree of motor block (p>0.05). In Group C, the decrease in SBP and DBP values that occurred at the fifteenth, twentieth, and thirtieth minutes of spinal anaesthesia was statistically significant when compared with the control values (SBP: p=0.0274, 0.0028, 0.0036, and DBP: p=0.0132, 0.0210, 0.0041). Hypotension developed in 10 (50%) of the 20 patients in Group C, and a 10mg intravenous (IV) bolus intervened with ephedrine. This result was statistically significant when compared with Group F, Group E, and Group N (p=0.005). Conclusion: As a result, it has been shown that norepinephrine, ephedrine, and 0.9% NaCl solution are similarly effective in preventing hypotension from developing after spinal anaesthesia.
dc.identifier.endpage1753
dc.identifier.issn2636-7688
dc.identifier.issue9
dc.identifier.startpage1746
dc.identifier.trdizinid482464
dc.identifier.urihttps://search.trdizin.gov.tr/tr/yayin/detay/482464
dc.identifier.urihttps://hdl.handle.net/20.500.12587/22232
dc.identifier.volume28
dc.indekslendigikaynakTR-Dizin
dc.language.isoen
dc.relation.ispartofAnnals of Medical Research
dc.relation.publicationcategoryMakale - Ulusal Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/openAccess
dc.snmzKA_20241229
dc.subjectAnestezi
dc.subjectGenel ve Dahili Tıp
dc.subjectKalp ve Kalp Damar Sistemi
dc.titleComparison of the effects of intravenous fluids and vasoconstrictive agents on the hemodynamic response developing in spinal anaesthesia
dc.typeArticle

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