Investigation of the contribution of concentrated growth factor (CGF) and processed lipoaspirate (PLA) to wound healing in diabetic rats

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dc.contributor.authorBolat, Ali
dc.contributor.authorGültekin, Yıldırım
dc.date.accessioned2025-01-21T16:17:07Z
dc.date.available2025-01-21T16:17:07Z
dc.date.issued2021
dc.departmentKırıkkale Üniversitesi
dc.description.abstractAim: The aim of the study is to show the effectiveness of concentrated growth factor (CGF) and processed lipoaspirate (PLA)in wound healing in diabetic rats.Materyal and Method: A total of 30 rats were used in the study. It was divided into 3 groups as concentrated growth factor,processed lipoaspirate and control group. The rats were made diabetic using Sreptozotocin IP. A 5mm diameter wound wascreated on one of the hind legs of all rats by using a punch. Concentrated growth factor and processed lipoaspirate were appliedto the lesions. Daily wound size and wound condition were recorded on days 3, 5 and 10. At the end of the study, blood sampleswere taken for TNF-?, TGF-?, IL-1, PDGF, FGF and VEGF measurements before the rats were sacrificed.Results: The mean wound diameters measured on the 3rd day in the study were 4.6±0.06 mm in the control group, 4.1±0.05mm in the concentrated growth factor group, and 4.4±0.07 mm in the processed lipoaspirate group. The wound diametersmeasured on the 5th day were 3.1±0.04 mm in the control group, 1.6±0.05 mm in the concentrated growth factor groupand 2.7±0.06 mm in the processed lipoaspirate group (p<0.01). The mean closure time of wounds was 5.3±1.1 days in theconcentrated growth factor group, 7.1±1.4 days in the processed lipoaspirate group, and 9.4±0.5 days in the control group. Allof the wounds were healed in all groups on the 10th day. This improvement rate in the concentrated growth factor group wasstatistically significant compared to the other two groups (p<0.01). Concentrated growth factor and PLA increased the speedof wound healing in diabetic rats. Inflammatory marker levels (TNF-?, TGF-?, IL-1, PDGF, FGF, VEGF) obtained from bloodsamples were higher than normal in all rats and there was no significant difference between the groups (p>0.05).Conclusion: In this study, it was shown that concentrated growth factor application was more effective than processedlipoaspirate application in wound healing in diabetic rats.
dc.identifier.doi10.32322/jhsm.804331
dc.identifier.endpage37
dc.identifier.issn2636-8579
dc.identifier.issue1
dc.identifier.startpage33
dc.identifier.trdizinid433435
dc.identifier.urihttps://doi.org/10.32322/jhsm.804331
dc.identifier.urihttps://search.trdizin.gov.tr/tr/yayin/detay/433435
dc.identifier.urihttps://hdl.handle.net/20.500.12587/22562
dc.identifier.volume4
dc.indekslendigikaynakTR-Dizin
dc.language.isoen
dc.relation.ispartofJournal of health sciences and medicine (Online)
dc.relation.publicationcategoryMakale - Ulusal Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/openAccess
dc.snmzKA_20241229
dc.subjectGenel ve Dahili Tıp
dc.titleInvestigation of the contribution of concentrated growth factor (CGF) and processed lipoaspirate (PLA) to wound healing in diabetic rats
dc.typeArticle

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