Evaluation of Neutrophil Extracellular Trap Formation on Smokers and Non-Smokers with Periodontitis

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dc.contributor.authorOcak, Gizem Yücesoy
dc.contributor.authorOlgun, H. Ebru
dc.contributor.authorYıldız, Kader
dc.contributor.authorGoksuluk, Merve Basol
dc.date.accessioned2025-01-21T16:13:40Z
dc.date.available2025-01-21T16:13:40Z
dc.date.issued2024
dc.departmentKırıkkale Üniversitesi
dc.description.abstractObjective: In this study, we aimed to evaluate neutrophil extracellular trap (NET) in smoker and non-smoker periodontitis patients. Materials and Methods: 21 subjects [non-smokers and periodontally healthy (S-P-) 7 people, non-smokers with periodontitis (S-P+) 7 people, smokers with periodontitis (S+P+) 7 people] were included in this study. Plaque index (PI), gingival index (GI), probing depth (PD) and clinical attachment level (CAL) parameters were recorded. The peripheral neutrophils isolated from the subjects were activated by phorbol 12-myristate 13-acetate (PMA) to induce NET formation. NET formed after the activation was measured with the fluorometer. Results: In the S-P- group PI, GI, PD and CAL values were found statistically significantly low (P=0,001; P=<0,001; P=0,003; P=<0,001, respectively). When compared to S+P+ group PMN counts were found low, but this difference was statistically at the border (P=0,05). When compared NET count values, it was the highest in the S+P+ group. When S-P- group and S+P+ group were compared, this difference was statistically significant (P=0,003); but between S-P+ and S+P+ groups, the difference was not statistically significant (P>0.05). NET count with PI, GI, PD, there was mild positive; with CAL strong positive relation has been found. Conclusion: As a result, even the S+P+ group NET count was found higher, the difference of S-P+ and S+P+ groups was not statistically significant. There is need more researches about smoking effect on NET formation in patients with periodontitis.
dc.identifier.doi10.69601/meandrosmdj.1536096
dc.identifier.endpage208
dc.identifier.issn2149-9063
dc.identifier.issue2
dc.identifier.startpage195
dc.identifier.trdizinid1260211
dc.identifier.urihttps://doi.org/10.69601/meandrosmdj.1536096
dc.identifier.urihttps://search.trdizin.gov.tr/tr/yayin/detay/1260211
dc.identifier.urihttps://hdl.handle.net/20.500.12587/21978
dc.identifier.volume25
dc.indekslendigikaynakTR-Dizin
dc.language.isoen
dc.relation.ispartofMeandros Medical And Dental Journal
dc.relation.publicationcategoryMakale - Ulusal Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/openAccess
dc.snmzKA_20241229
dc.subjectTamamlayıcı ve Entegre Tıp
dc.subjectTıbbi Araştırmalar Deneysel
dc.titleEvaluation of Neutrophil Extracellular Trap Formation on Smokers and Non-Smokers with Periodontitis
dc.typeArticle

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