Side effects of metoclopramide: Does it deserve to prescribe for nausea, vomiting?
Yükleniyor...
Tarih
2010
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
Erişim Hakkı
info:eu-repo/semantics/openAccess
Özet
Metoklopramid antiemetik olarak kullanılan dopamin reseptör antagonistidir. Önerilen tedavi dozlarında da görülebilen ekstrapiramidal etkiler çocuklarda sık görülen akut yan etkilerdendir. Kırıkkale Üniversitesi Tıp Fakültesi ve Sağlık Bakanlığı Kırıkkale Çocuk Sağlığı ve Hastalıkları Hastanesi acil polikliniklerine Mart 2006-Mart 2007 tarihleri arasında metoklopramid kullanımı sonrası ortaya çıkan yan etkileri ile başvuran 19 olgu retrospektif olarak değerlendirildi. Çalışmadaki hastaların yaşları 4 ila 174 ay arasında değişmekte olup 10 (%52,7)’u kızdı. Görülen yan etkiler; distonik reaksiyon, okulogirik kriz ve konvülsiyon idi. Tüm hastalarda semptomlar metoklopramid kullanımını takip eden ilk üç günde ortaya çıkmıştı. 17 hasta tek doz biperidene yanıt verirken bir hastaya ikinci doz uygulanması gerekmişti. Bir hastada konvülsiyon nedeniyle tedaviye midazolom eklenmişti. Klinisyenler metoklopramide kullanımı sonrası yan etkiler açısından dikkatli olmalıdır.
Metoclopramide is a dopamine receptor antagonist which is used as an anti-emetic. Extrapyramidal reactions which could be seen even at recommended doses are the most common acute side effects in children. This retrospective study, evaluated adverse reactions of metoclopramide in 19 patients who had attended to the emergency departments of Kırıkkale University School of Medicine and Ministry of Health Kırıkkale Children’s Hospital between March 2006 and March 2007. Patients in our study were between 4 and 174 months of age and 10 (52.7%) of them were females. Observed adverse reactions were dystonic reaction, oculogyrics crisis and convulsion. In all patients symptoms arised within the first to 3rd days of metoclopramide usage. All 17 patients responded to one dose Biperiden administration except one, who needed the second dose. One patient had convulsion and midazolam was added to the treatment. Physicians must be aware of adverse reactions caused by metoclopramide.
Metoclopramide is a dopamine receptor antagonist which is used as an anti-emetic. Extrapyramidal reactions which could be seen even at recommended doses are the most common acute side effects in children. This retrospective study, evaluated adverse reactions of metoclopramide in 19 patients who had attended to the emergency departments of Kırıkkale University School of Medicine and Ministry of Health Kırıkkale Children’s Hospital between March 2006 and March 2007. Patients in our study were between 4 and 174 months of age and 10 (52.7%) of them were females. Observed adverse reactions were dystonic reaction, oculogyrics crisis and convulsion. In all patients symptoms arised within the first to 3rd days of metoclopramide usage. All 17 patients responded to one dose Biperiden administration except one, who needed the second dose. One patient had convulsion and midazolam was added to the treatment. Physicians must be aware of adverse reactions caused by metoclopramide.
Açıklama
Anahtar Kelimeler
Genel ve Dahili Tıp
Kaynak
Yeni Tıp Dergisi
WoS Q Değeri
Scopus Q Değeri
Cilt
27
Sayı
2
