Neuroprotective role of n-acetylcysteine (NAC): countering doxorubicin neurotoxicity via TH, Nurr1, and iNOS expression

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dc.contributor.authorAnteplioğlu, Tuğçe
dc.contributor.authorÇınar, Miyase
dc.contributor.authorYaldız, Gözde
dc.contributor.authorKayabaşı, Sevgi Betül
dc.contributor.authorDuru, Özkan
dc.contributor.authorKabakçı, Ruhi
dc.date.accessioned2025-01-21T16:13:22Z
dc.date.available2025-01-21T16:13:22Z
dc.date.issued2024
dc.departmentKırıkkale Üniversitesi
dc.description.abstractChemotherapy is an effective treatment for cancer, but it can cause cognitive disorders broadly referred to as “chemobrain.” One of the most commonly used chemotherapeutics, doxorubicin (DOX), has been associated with the potential for brain damage and cognitive dysfunction. N-acetylcysteine (NAC) has been identified as a potential brain protector with antiapoptotic, antioxidant, and anti-inflammatory effects. The objective of this study was to investigate the potential protective effect of NAC against DOX-induced brain damage. Female Wistar albino rats were randomly assigned to one of three groups: control, DOX, or NAC prophylaxis. Brain samples were collected for histopathological and immunohistochemical analyses, with a particular focus on regions that are crucial for cognition and memory. The DOX group exhibited significant histopathological changes, including neuronal shrinkage, degeneration, and necrosis in the striatum, hippocampal region, and cerebral cortex. Immunohistochemical analysis revealed the presence of neuroinflammation and neurodegeneration, with an increase in inducible nitric oxide synthetase (iNOS) immunopositivity. Administration of NAC effectively reduced iNOS immunopositivity, neuronal damage, degeneration, and necrosis in the prophylaxis group. Among the brain regions examined, the prophylaxis group demonstrated the most effective protection in the hippocampal region. Therefore, NAC has the potential to protect against or alleviate DOX-induced cognitive impairments.
dc.identifier.doi10.24880/meditvetj.1541540
dc.identifier.endpage305
dc.identifier.issn3023-8447
dc.identifier.issue2
dc.identifier.startpage299
dc.identifier.trdizinid1264659
dc.identifier.urihttps://doi.org/10.24880/meditvetj.1541540
dc.identifier.urihttps://search.trdizin.gov.tr/tr/yayin/detay/1264659
dc.identifier.urihttps://hdl.handle.net/20.500.12587/21909
dc.identifier.volume9
dc.indekslendigikaynakTR-Dizin
dc.language.isoen
dc.relation.ispartofMediterranean veterinary journal
dc.relation.publicationcategoryMakale - Ulusal Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/openAccess
dc.snmzKA_20241229
dc.subjectTıbbi Araştırmalar Deneysel
dc.subjectGenel ve Dahili Tıp
dc.subjectNörolojik Bilimler
dc.subjectBiyokimya ve Moleküler Biyoloji
dc.titleNeuroprotective role of n-acetylcysteine (NAC): countering doxorubicin neurotoxicity via TH, Nurr1, and iNOS expression
dc.typeArticle

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