Effect of pre-haemolytic concentrations of α, β, and γ cyclodextrins on the osmotic fragility of dog erythrocytes

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dc.contributor.authorArikan, Şevket
dc.contributor.authorYigit, Ayşe Arzu
dc.contributor.authorZengin N.
dc.date.accessioned2020-06-25T15:13:21Z
dc.date.available2020-06-25T15:13:21Z
dc.date.issued2004
dc.departmentKırıkkale Üniversitesi
dc.description.abstractKnowledge of the adverse effects of cyclodextrins on erythrocytes is important in view of the growing number of their potential applications in food, cosmetic, drug and chemical industries to increase aqueous solubility and stability, and reduce or eliminate the unpleasant taste and smell of many products. The experiment was conducted to examine the effect of pre-haemolytic concentrations of ?-, ?- and ?-cyclodextrins on the osmotic fragility of erythrocytes. Blood samples collected from 8 healthy Turkish Kangal dogs were analysed within 3 h of collection. Erythrocyte suspensions were mixed with various concentrations of ?-, ?-, or ?-cyclodextrins. The mixtures were then incubated for 30 min at 37°C and osmotic fragility of erythrocytes was measured. Incubation of the erythrocyte suspensions with the all three cyclodextrins induced a dose-dependent increase in the osmotic fragility of erythrocytes. Initial haemolysis (10%) in ?-, ?-, and ?-cyclodextrin treated groups was at 8, 4 and 46 mM cyclodextrin concentrations, respectively. In conclusion, these results indicate that pre-haemolytic concentrations of all three cyclodextrins studied might induce membrane disruption, that may cause removal of membrane components from erythrocytes. When cyclodextrins are even used in a pre-haemolytic concentrations, it might reduce life span of erythrocytes.en_US
dc.identifier.citationclosedAccessen_US
dc.identifier.endpage503en_US
dc.identifier.issn00351555
dc.identifier.issue10en_US
dc.identifier.scopus2-s2.0-9144254592
dc.identifier.scopusqualityN/A
dc.identifier.startpage500en_US
dc.identifier.urihttps://hdl.handle.net/20.500.12587/1753
dc.identifier.volume155en_US
dc.indekslendigikaynakScopus
dc.language.isoen
dc.relation.ispartofRevue de Medecine Veterinaire
dc.relation.publicationcategoryMakale - Ulusal Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectCyclodextrinen_US
dc.subjectDogen_US
dc.subjectErythrocyteen_US
dc.subjectOsmotic fragilityen_US
dc.titleEffect of pre-haemolytic concentrations of α, β, and γ cyclodextrins on the osmotic fragility of dog erythrocytesen_US
dc.typeArticle

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