Unidentified bright objects in neurofibromatosis type 1: Results of diffusion tensor imaging in children and adolescents

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dc.authoridGullmar, Daniel/0000-0001-8693-8099
dc.contributor.authorMentzel, Hans-Joachim
dc.contributor.authorKaradag, Demet
dc.contributor.authorGullmar, Daniel
dc.contributor.authorLobel, Ulrike
dc.contributor.authorReichenbach, Jurgen R.
dc.contributor.authorSedlacik, Jan
dc.contributor.authorSeidel, Jorg
dc.date.accessioned2025-01-21T16:55:46Z
dc.date.available2025-01-21T16:55:46Z
dc.date.issued2006
dc.departmentKırıkkale Üniversitesi
dc.description.abstractTo evaluate by means of diffusion tensor magnetic resonance imaging (DTI) if changes in apparent diffusion coefficient (ADC) and diffusion tensor fraction anisotropy (FA) in unidentified bright objects (UBOs) and perilesional normal appearing brain regions of children with neurofibromatosis type 1 (NF1) can be observed. Ten children with NF1 underwent conventional magnetic resonance imaging and DTI. The ADC and FA in UBOs and perilesional normal appearing brain of NF1 patients were compared with the same regions of the brain of controls. The ADC increased significantly for UBOs and surrounding normal appearing brain tissue of the brain in children with NF1. We observed no significant differences in FA between the UBOs and perilesional areas or that of controls. Although there is limited neuropathologic information about UBOs, detection of diffusion properties of UBOs can be used to understand tissue characteristics of UBOs, noninvasively.
dc.description.sponsorshipGerman Academic Exchange Service (DAAD); Interdisciplinary Center for Clinical Research (IZKF), Jena, Germany [TP1.8]
dc.description.sponsorshipDemet Karadag was supported by a fund of the German Academic Exchange Service (DAAD). A part of this studywas supported by the Interdisciplinary Center for Clinical Research (IZKF), Jena, Germany, within the project TP1.8.
dc.identifier.endpage31
dc.identifier.issn1304-2580
dc.identifier.issn1875-9041
dc.identifier.issue1
dc.identifier.startpage27
dc.identifier.urihttps://hdl.handle.net/20.500.12587/25836
dc.identifier.volume4
dc.identifier.wosWOS:000215502300005
dc.identifier.wosqualityN/A
dc.indekslendigikaynakWeb of Science
dc.language.isoen
dc.publisherGeorg Thieme Verlag Kg
dc.relation.ispartofJournal of Pediatric Neurology
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.snmzKA_20241229
dc.subjectDiffusion tensor imaging; fraction anisotropy; apparent diffusion coefficient; neurofibromatosis; unknown bright objects; phacomatoses
dc.titleUnidentified bright objects in neurofibromatosis type 1: Results of diffusion tensor imaging in children and adolescents
dc.typeArticle

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