Choroid epithelial cells: Source cerebrospinal fluid progesterone in sheep?

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dc.contributor.authorKarahan, Siyami
dc.contributor.authorYarım, Gül F.
dc.contributor.authorYarım, Murat
dc.date.accessioned2020-06-25T15:13:52Z
dc.date.available2020-06-25T15:13:52Z
dc.date.issued2007
dc.departmentKırıkkale Üniversitesi
dc.description.abstractThe present study was conducted to immunolocalize 3?-hydroxysteroid dehydrogenase (3?-HSD), an enzyme metabolizing pregnenolone to progesterone in the choroid plexus of the lateral ventricle in sheep, as well as to measure progesterone concentration in cerebrospinal fluid (CSF) and plasma using radioimmunoassay (RIA). Akkaraman breed rams (n = 16) and ewes (n = 16) were utilized in the study. 3?-HSD was immunolocalized in choroid epithelial cells of the choroid plexus with an apparent cytoplasmic immunoreactivity. Progesterone was detected in CSF with no significant differences between the ewes (0.76 ± 0.14 ng/mL) and rams (0.74 ± 0.13 ng/mL) (p > 0.05). However, the plasma progesterone concentration in the ewes (0.27 ± 0.04 ng/mL) was significantly higher than that of the rams (0.11 ± 0.02 ng/mL) (p < 0.001). Consequently, CSF in sheep contains progesterone in significant levels. As evidenced by 3?-HSD immunoreactivity, choroid epithelial cells may be a site of progesterone synthesis in sheep.en_US
dc.identifier.citationclosedAccessen_US
dc.identifier.endpage937en_US
dc.identifier.issn00258628
dc.identifier.issue8en_US
dc.identifier.scopus2-s2.0-34548036033
dc.identifier.scopusqualityQ4
dc.identifier.startpage935en_US
dc.identifier.urihttps://hdl.handle.net/20.500.12587/1956
dc.identifier.volume63en_US
dc.indekslendigikaynakScopus
dc.language.isoen
dc.relation.ispartofMedycyna Weterynaryjna
dc.relation.publicationcategoryMakale - Ulusal Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subject3?-hydroxysteroid dehydrogenaseen_US
dc.subjectCerebrospinal fluiden_US
dc.subjectProgesteroneen_US
dc.subjectSheepen_US
dc.titleChoroid epithelial cells: Source cerebrospinal fluid progesterone in sheep?en_US
dc.typeArticle

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