Preparation and characterization of pH-sensitive alginate-g-poly(N-vinyl-2-pyrrolidone)/gelatin blend beads

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dc.contributor.authorİnal M.
dc.contributor.authorIşıklan N.
dc.contributor.authorYiğitoğlu M.
dc.date.accessioned2020-06-25T15:17:50Z
dc.date.available2020-06-25T15:17:50Z
dc.date.issued2017
dc.departmentKırıkkale Üniversitesi
dc.description.abstractIn this study, pH-sensitive alginate-g-poly(N-vinyl-2-pyrrolidone)/gelatin (SA-g-PVP/Gel) blend beads were produced as controlled release system. Structural features of the SA-g-PVP/Gel beads were characterized by FTIR, X-RD, DSC, SEM and mercury intrusion-porosimetry. In vitro nifedipine (NFD) release was investigated at pH 1.2 for 2 h and followed by immersing at pH 7.4 for 6 h. Effects of diverse parameters such as grafting of PVP, copolymer/gelatin blend ratio, concentration of cross-linker and drug amount on the release of NFD were investigated. The NFD release from SA-g-PVP/Gel beads demonstrated pH-sensitivity of drug release. Cytotoxicity experiments of SA-g-PVP and SA-g-PVP/Gel beads displayed their biocompatible character. © 2017 The Korean Society of Industrial and Engineering Chemistryen_US
dc.identifier.doi10.1016/j.jiec.2017.03.034
dc.identifier.endpage137en_US
dc.identifier.issn1226086X
dc.identifier.scopus2-s2.0-85017125464
dc.identifier.scopusqualityQ1
dc.identifier.startpage128en_US
dc.identifier.urihttps://doi.org/10.1016/j.jiec.2017.03.034
dc.identifier.urihttps://hdl.handle.net/20.500.12587/2543
dc.identifier.volume52en_US
dc.indekslendigikaynakScopus
dc.language.isoen
dc.publisherKorean Society of Industrial Engineering Chemistryen_US
dc.relation.ispartofJournal of Industrial and Engineering Chemistry
dc.relation.publicationcategoryMakale - Ulusal Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectGelatinen_US
dc.subjectGraft copolymeren_US
dc.subjectPoly(N-vinyl-2-pyrrolidone)en_US
dc.subjectPolymeric blenden_US
dc.subjectSodium alginateen_US
dc.titlePreparation and characterization of pH-sensitive alginate-g-poly(N-vinyl-2-pyrrolidone)/gelatin blend beadsen_US
dc.typeArticle

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