The Impact of Prodromal Stage Non-Motor Symptoms on Clinical Progression in Parkinson’s Disease
[ X ]
Tarih
2022
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
Erişim Hakkı
info:eu-repo/semantics/openAccess
Özet
Objectives: Several non-motor symptoms (NMSs) were described in the prodromal Parkinson’s disease (PD). The aim of this study is to investigate the impact of the presence of prodromal NMSs on clinical progression of PD. Materials and Methods: We questioned the presence of NMSs in the prediagnostic stage in patients with PD. Group 1 reported at least one prodromal NMS and Group 2 reported no prodromal NMSs. As recommended by the Movement Disorder Society Task Force, the total likelihood ratios (LRs) of NMSs were calculated and correlated with disease progression. Clinical progression was determined by dividing the Unified Parkinson’s Disease Rating Scale Part III total score by the duration of the disease. Generalized linear model (GzLM) was used to determine associations between clinical progression rate and the predictor variables. Results: Group 1 had 48 patients (24 male, 24 female), and Group 2 had 46 patients (32 male, 14 female). Both groups were similar in terms of demographic and disease characteristics. Depression and constipation (for each symptom, 18 patients and 37.5%) were common in Group 1. The rate of clinical progression was higher in Group 1 than in Group 2 (p=0.037). There was no significant correlation between clinical progression rate and LRs of NMSs in Group 1 (rs=0.10, p=0.49). However, age of the diagnosis was the only significant factor associated with the clinical progression (p=0.69). Conclusion: Prodromal NMSs do not seem to impact the rate of disease progression, which may be explained by the non-dopaminergic and extra nigro-striatal pathway that cause NMSs.
Açıklama
Anahtar Kelimeler
Tıbbi Araştırmalar Deneysel, Genel ve Dahili Tıp, Nörolojik Bilimler
Kaynak
Ankara Üniversitesi Tıp Fakültesi Mecmuası
WoS Q Değeri
Scopus Q Değeri
Cilt
75
Sayı
1
