A Glucose Selective Non-enzymatic Potentiometric Chitosan-Goldnanoparticle Nanocomposite Sensor Based on Boronic Acid-Diol Recognition
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Tarih
2018
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
Wiley-VCH Verlag
Erişim Hakkı
info:eu-repo/semantics/closedAccess
Özet
A new non-enzymatic glucose sensor based gold nanoparticle (AuNp)-chitosan (Ch/AuNp) was developed in this study. Gold nanoparticles were synthesized by using the green synthesis method, in which chitosan is used as both reducing and stabilizing agent. Gold nanoparticle surfaces were modified with different molecular agents (4-mercaptophenyl boronic acid,MPB, and 1-decanethiol,DT) being sensitive to glucose. Modified gold nanoparticles were immobilized to electrode surfaces and used for the glucose measurements by the potentiometric method. The best working conditions were determined for the glucose measurements. It was found that linear working range is 0.5–30 mM, while limit of detection is 0.3 mM for the glucose measurement of the prepared non-enzymatic sensor. It was stated that the prepared sensor could be used at least 6 times and glucose response decreased approximately 10.97 % when it is waited for 30 days. Interference effect of some molecules for glucose measurement was investigated and usability of developed sensor was tested in human blood serum. © 2018 Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim
Açıklama
Anahtar Kelimeler
boronic acid, Glucose, gold nanoparticle, molecular recognition, potentiometry
Kaynak
Electroanalysis
WoS Q Değeri
Scopus Q Değeri
Q2
Cilt
30
Sayı
11
