Effects of amitraz plus-Parapoxvirus ovis on EGF, VEGF, IGF-1 and IGF-2 in canine generalized demodicosis

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dc.authoridPEKMEZCI, Didem/0000-0003-2072-8165
dc.authoridSozmen, Mahmut/0000-0001-7976-4051
dc.contributor.authorYarim, F. Gul
dc.contributor.authorPekmezci, Didem
dc.contributor.authorYarim, Murat
dc.contributor.authorYagci, B. Bugrahan
dc.contributor.authorGokceoglu, Ayris
dc.contributor.authorSozmen, Mahmut
dc.contributor.authorPekmezci, G. Zafer
dc.date.accessioned2025-01-21T16:38:14Z
dc.date.available2025-01-21T16:38:14Z
dc.date.issued2022
dc.departmentKırıkkale Üniversitesi
dc.description.abstractObjective. The purpose of the study is to investigate the effect of treatment with amitraz plus-Parapoxvirus ovis (IPPVO) on serum concentrations and skin expressions of insulin-like growth factor (IGF)-1 and -2, epidermal growth factor (EGF), vascular endothelial growth factor (VEGF), in dogs suffering from generalised demodicosis (GD). Materials and Methods. GD affected dogs were injected 1 ml IPPVO on days 0, 2 and 9 subcutaneously in addition to amitraz (0.025%) treatment twice weekly for 80 days. IGF-1, IGF-2, EGF and VEGF concentrations in blood serum were measured by canine-specific enzyme-linked immunosorbent assay kit. EGF, VEGF, IGF-1, and IGF-2 expressions in skin biopsy specimens were examined immunohistochemically. Results. After the treatment of the dogs with amitraz plus-IPPVO in GD, we demonstrated a significant reduction in both circulating concentrations and skin expressions of EGF, VEGF, IGF-1, and IGF-2, which have a role in preserving skin integrity and wound healing. Conclusions. Results of this study suggest that IGF-1, IGF-2 EGF, and VEGF have a crucial role in the progression of GD in dogs. It is believed that the findings from this study will contribute to the development of new strategies for the treatment of GD, which is an important health problem for dogs.
dc.identifier.doi10.21897/rmvz.2619
dc.identifier.issn0122-0268
dc.identifier.issn1909-0544
dc.identifier.issue3
dc.identifier.urihttps://doi.org/10.21897/rmvz.2619
dc.identifier.urihttps://hdl.handle.net/20.500.12587/24604
dc.identifier.volume27
dc.identifier.wosWOS:000948079100012
dc.identifier.wosqualityQ4
dc.indekslendigikaynakWeb of Science
dc.language.isoes
dc.publisherUniv Cordoba
dc.relation.ispartofRevista Mvz Cordoba
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/openAccess
dc.snmzKA_20241229
dc.subjectDemodex canis; dog; generalized demodicosis; growth factor; skin
dc.titleEffects of amitraz plus-Parapoxvirus ovis on EGF, VEGF, IGF-1 and IGF-2 in canine generalized demodicosis
dc.typeArticle

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