Comparison of the Effectiveness of Topical and Oral Beta Blockers in the Treatment of Childhood Hemangiomas

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dc.contributor.authorYüksel, Kerim Faruk
dc.contributor.authorKandur, Yaşar
dc.contributor.authorAlpcan, Ayşegül
dc.contributor.authorTursun, Serkan
dc.contributor.authorVural, Sevde Nur
dc.contributor.authorAlbayrak, Meryem
dc.date.accessioned2025-01-21T16:12:38Z
dc.date.available2025-01-21T16:12:38Z
dc.date.issued2023
dc.departmentKırıkkale Üniversitesi
dc.description.abstractPurpose: Hemangiomas are the most common vascular tumors in childhood, and the treatment options have undergone profound changes in recent years. In this study, we aimed to compare the efficacy and safety of beta-blockers on hemangiomas, both topi-cal and oral, with non-pharmacological treatment in the pediatric age group. Material and Methods: We retrospectively reviewed the medical records of pediatric patients with hemangiomas. Results: Fifty-three patients (F/M=40/13) were enrolled in this study. Superficial hemangiomas were detected in 14 (26.4%) patients, and deep hemangiomas were detected in 39 (73.6%) patients. Seventeen patients were followed without medication, 19 were treated with a topical beta blocker, and 17 were treated with an oral beta blocker. Twelve patients with superficial hemangi-omas were followed without medication, while two received topical timolol treatment. A comparison of lesion progression in patients with superficial hemangiomas in the non-pharmacological treatment and topical treatment groups showed that the mean scores of success, in terms of mean fading and reduction in lesion depth, were significantly higher at the first month (7.0 vs. 1.66; p=0.049; 6.0 vs. 1.5; p=0.045). Among patients with deep hemangiomas, a comparison of mean fading scores showed no difference between the oral and topical treatment groups in the first and fourth months (p=0.551, p=0.551). Conclusion: We believe that oral beta-blockers can be used instead of topical treatment in the future, and they will be preferred more by clinicians and families due to less side effects.
dc.identifier.doi10.46332/aemj.1133840
dc.identifier.endpage314
dc.identifier.issn2619-9203
dc.identifier.issue3
dc.identifier.startpage309
dc.identifier.trdizinid1213149
dc.identifier.urihttps://doi.org/10.46332/aemj.1133840
dc.identifier.urihttps://search.trdizin.gov.tr/tr/yayin/detay/1213149
dc.identifier.urihttps://hdl.handle.net/20.500.12587/21734
dc.identifier.volume7
dc.indekslendigikaynakTR-Dizin
dc.language.isoen
dc.relation.ispartofAhi Evran Medical Journal
dc.relation.publicationcategoryMakale - Ulusal Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/openAccess
dc.snmzKA_20241229
dc.subjectDermatoloji
dc.subjectPediatri
dc.titleComparison of the Effectiveness of Topical and Oral Beta Blockers in the Treatment of Childhood Hemangiomas
dc.typeArticle

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