Investigation of the Pharmacokinetic Properties and Theoretical Chemical Activities of 7,8-Dihydroxyflavone and 4'-Dimethylamino-7,8-Dihydr-oxyflavone

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dc.authoridKorkmaz, Orhan/0000-0003-1410-740X
dc.authoridSener, Erol/0000-0003-1902-4785
dc.authoridgokalp, faik/0000-0003-4363-3839
dc.authoridKarakaya, Muhammed Fatih/0000-0003-3331-8472
dc.contributor.authorKarakaya, Muhammed Fatih
dc.contributor.authorGokalp, Faik
dc.contributor.authorSener, Erol
dc.contributor.authorKorkmaz, Orhan Tansel
dc.date.accessioned2025-01-21T16:42:13Z
dc.date.available2025-01-21T16:42:13Z
dc.date.issued2023
dc.departmentKırıkkale Üniversitesi
dc.description.abstractAims Flavonoids naturally exist in plants as secondary metabolites. In this study, the aim is to determine and compare the theoretical and in vivo chemical activities of 7,8-dihydroxyflavone (7,8-DHF) and 4'dimethylamino-7,8-dihydroxyflavone (4'-DMA-7,8-DHF), tyrosine receptor kinase B (TrkB) receptor agonist flavonoid molecules with reported potent neuroprotective effects. Methods The density functional theory (DFT) (RB3LYP) method was used for the theoretical chemical analysis. For the in vivo studies, 6-month-old Wistar rats were used in two groups (n=8). 7,8-DHF and 4'-DMA-7,8-DHF (5 mg/kg) were administered intraperitoneally (ip) to each group. Then, plasma samples were collected by carotid catheterization, and brain samples by the microdialysis technique were collected simultaneously for 12 h from awake rats. The level of 7,8-DHF and 4'-DMA-7,8-DHF in blood and brain samples were analyzed and their pharmacokinetics were determined. Results Theoretical calculations show that 7,8-DHF is slightly more stable than 4'-DMA-7,8-DHF. The in vivo pharmacokinetic results show that the maximum concentration of 7,8-DHF was about 48 ng/mL, whereas it was only 8 ng/mL for 4'-DMA-7,8-DHF. Conclusion Our results suggest that the 4'-DMA-7,8-DHF is more unstable and is more prone to binding to TrkB than 7,8-DHF. On the other hand, the in vivo pharmacokinetic results show that 7,8-DHF is more stable than 4'-DMA-7,8-DHF when it is applied systemically at therapeutic concentrations.
dc.description.sponsorshipScientific Research Application and Research Center (AUBIBAM) [BAP-2016/016]
dc.description.sponsorshipAccession of Gaussian 09, Revision C.; 01 (2010), was provided by Kirikkale University project BAP-2016/016. All the liquid chromatography and mass spectrometry studies specified in this study were carried out at the Anadolu University Plant, Pharmaceutical and Scientific Research Application and Research Center (AUBIBAM).
dc.identifier.doi10.2174/1573412919666230313143549
dc.identifier.endpage323
dc.identifier.issn1573-4129
dc.identifier.issn1875-676X
dc.identifier.issue4
dc.identifier.startpage317
dc.identifier.urihttps://doi.org/10.2174/1573412919666230313143549
dc.identifier.urihttps://hdl.handle.net/20.500.12587/25016
dc.identifier.volume19
dc.identifier.wosWOS:001026790800006
dc.identifier.wosqualityQ4
dc.indekslendigikaynakWeb of Science
dc.language.isoen
dc.publisherBentham Science Publ Ltd
dc.relation.ispartofCurrent Pharmaceutical Analysis
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.snmzKA_20241229
dc.subjectBrain-derived neurotrophic factor; flavonoids; TrkB; 7; 8-dihydroxyflavone; 4'-dimethylamino-7; pharmacokinetics
dc.titleInvestigation of the Pharmacokinetic Properties and Theoretical Chemical Activities of 7,8-Dihydroxyflavone and 4'-Dimethylamino-7,8-Dihydr-oxyflavone
dc.typeArticle

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