Combined effects of the implementation of magnesium and ascorbic acid on myocardial ischemia-reperfusion in open heart surgery

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dc.contributor.authorGültekin, Yıldırım
dc.contributor.authorGüzel, Abdulkadir
dc.contributor.authorKarakaya, Atalay
dc.contributor.authorBeşoğul, Yavuz
dc.date.accessioned2025-01-21T16:13:09Z
dc.date.available2025-01-21T16:13:09Z
dc.date.issued2021
dc.departmentKırıkkale Üniversitesi
dc.description.abstractAim: This study aimed to investigate the combined effects of magnesium (Mg) and high dose ascorbic acid on cardiac ischemia-reperfusion (IR) injury. Material and Method: This study was performed on 45 patients that were scheduled for coronary artery bypass graft (CABG) operations. The patients were divided into three equal groups. Group C received 50 mg/kg ascorbic acid; Group CM received the same dose of ascorbic acid plus 30 mg/kg Mg; Group K received neither ascorbic acid nor Mg. At various times during the operation, the blood levels of malondialdehyde (MDA), serum creatine kinase MB (CK-MB), and lactate dehydrogenase (LDH) levels were analyzed. Results: There were statistically significant decreases in arrhythmia requiring intervention in Group CM compared to Group K (P=0.026). MDA levels increased in all groups but MDA 2 and MDA 3 levels were found to be statistically significantly lower in Group C and Group CM than in Group K (P=0.009, P=0.012, P=0.009 and P=0.006 respectively). However, inhibition of lipid peroxidation in both Group C and Group CM was not parallel to cardiac enzymes and hemodynamic measurements. There was no significant statistical difference in the cardiac enzyme levels between Group K, Group C, and Group CM (p>0.05). Conclusion: To reduce the IR, Mg with a high dose of ascorbic acid may be efficacious in patients undergoing cardiac surgery. A larger population group is needed to prove the results of this study.
dc.identifier.doi10.38053/acmj.982137
dc.identifier.endpage326
dc.identifier.issn2718-0115
dc.identifier.issue4
dc.identifier.startpage319
dc.identifier.trdizinid1243098
dc.identifier.urihttps://doi.org/10.38053/acmj.982137
dc.identifier.urihttps://search.trdizin.gov.tr/tr/yayin/detay/1243098
dc.identifier.urihttps://hdl.handle.net/20.500.12587/21850
dc.identifier.volume3
dc.indekslendigikaynakTR-Dizin
dc.language.isoen
dc.relation.ispartofAnatolian Current Medical Journal
dc.relation.publicationcategoryMakale - Ulusal Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/openAccess
dc.snmzKA_20241229
dc.subjectKalp ve Kalp Damar Sistemi
dc.subjectCerrahi
dc.titleCombined effects of the implementation of magnesium and ascorbic acid on myocardial ischemia-reperfusion in open heart surgery
dc.typeArticle

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