Effects of esmolol on lung injury induced by lower extremity Ischemia-reperfusion

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dc.authoridKucuk, Aysegul/0000-0001-9316-9574
dc.contributor.authorSabuncu, Ulku
dc.contributor.authorSezen, Saban Cem
dc.contributor.authorKucuk, Aysegul
dc.contributor.authorSalman, Nevriye
dc.contributor.authorSabuncu, Timucin
dc.contributor.authorKip, Gulay
dc.contributor.authorKurtipek, Omer
dc.date.accessioned2025-01-21T16:33:07Z
dc.date.available2025-01-21T16:33:07Z
dc.date.issued2022
dc.departmentKırıkkale Üniversitesi
dc.description52nd National Congress of the Turkish-Society-of-Anesthesiology-and-Reanimation (TARK) -- NOV 07-11, 2018 -- Antalya, TURKEY
dc.description.abstractAim: After hind limb ischemia-reperfusion (I/R), impairments in remote organs are frequent. Lung tissue is the organ most affected by the remote organ damage. The lung damage increases ventilatory support, the need for inotropic agents and mortality. Many drugs and methods have been used in attempts to prevent or reduce this damage. The aim of this study is to investigate the protective effects of esmolol infusion on lung tissue prior to I/R created in the lower extremity. Material and Methods: The study was performed between 11 and 14 April 2018 in Gazi University Experimental Animal Research Center, Ankara, Turkey. After obtaining ethics committee approval, 24 rats were randomly divided into 4 groups: Control (Group C), Esmolol (Group E), Ischemia-reperfusion (Group I/R), and I/R-Esmolol (Group I/RE). Esmolol (200 mu g/kg/min intravenous) was applied 30 minutes before the procedure. The biochemical and histopathological parameters of lung tissue samples were compared. Results: Neutrophil infiltration/aggregation, alveolar wall thickness, and total lung injury scores were significantly higher in the I/R group than in the C and E groups. In addition, neutrophil infiltration/aggregation, alveolar wall thickness, and total lung injury scores in the I/R group were statistically higher than in the I/R-E group (p=0.030, p=0.010, p=0.001, respectively). Malondialdehyde levels, catalase (CAT) and paraoxonase (PON) enzyme activities in the I/R group were significantly higher than in the C, E, and I/R-E groups. Glutathione S- transferase ( GSH) enzyme activity was similar in all groups. Discussion: It was found that esmolol infusion at 200 mu g/kg/min intravenously-reduced oxidative stress when administered 30 minutes before ischemia in rats and partially corrected the damage caused by I/R in lung histopathology.
dc.description.sponsorshipTurkish Soc Anesthesiol & Reanimat
dc.identifier.doi10.4328/ACAM.21025
dc.identifier.endpage615
dc.identifier.issn2667-663X
dc.identifier.issue6
dc.identifier.startpage611
dc.identifier.urihttps://doi.org/10.4328/ACAM.21025
dc.identifier.urihttps://hdl.handle.net/20.500.12587/23733
dc.identifier.volume13
dc.identifier.wosWOS:001027513600005
dc.identifier.wosqualityN/A
dc.indekslendigikaynakWeb of Science
dc.language.isoen
dc.publisherBayrakol Medical Publisher
dc.relation.ispartofAnnals of Clinical and Analytical Medicine
dc.relation.publicationcategoryKonferans Öğesi - Uluslararası - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/openAccess
dc.snmzKA_20241229
dc.subjectReperfusion Damage; Ischemia-Reperfusion; Lung Injuries; Beta-Antagonists
dc.titleEffects of esmolol on lung injury induced by lower extremity Ischemia-reperfusion
dc.typeConference Object

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