Clinical use of specific markers TAS, TOS, PON and IL-6 by the evaluation of kidney damage in patients receiving SWL treatment

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dc.contributor.authorYuvanç, Ercan
dc.contributor.authorTuğlu, Devrim
dc.contributor.authorGür, Serhan
dc.contributor.authorOzan, Tunç
dc.contributor.authorKısa, Üçler
dc.contributor.authorBatıslam, Ertan
dc.contributor.authorErdal, Yılmaz Selim
dc.date.accessioned2025-01-21T16:19:27Z
dc.date.available2025-01-21T16:19:27Z
dc.date.issued2018
dc.departmentKırıkkale Üniversitesi
dc.description.abstractAim: Beside efficacy of the shock wave lithotripsy (SWL) procedure, also its negative effects on the kidneys, its relation with the oxidant/antioxidant balance and the search after biomarkers for the detection of this negative effect gained interest in the recent years. The aim of the study is to investigate the possible usage of total antioxidant status (TAS), total oxidant status (TOS), oxidative stress index (OSI), Paraoxonase-1(PON-1) and Interleukin 6 (IL-6) parameters as biomarkers for renal injury/trauma in the early period by patients undergoing SWL due to kidney stones. Material and Methods: Forty patients receiving SWL therapy due to kidney stones were included to study by collecting their blood samples before and 2 hours after the procedure. Results: It was observed that SWL therapy has deteriorated the oxidant/antioxidant balance in terms of the oxidants by analyzing the increase of IL-6 (P <0,01) and decrease in PON-1 (P = 0.049). There was no change observed in TAS (P = 0.178) and TOS (P = 0.175) and OSI (P = 0.551) parameters. Conclusion: This has shown that IL-6 and PON-1 may be more sensitive markers of renal injury after SWL in early period.
dc.identifier.doi10.18663/tjcl.432886
dc.identifier.endpage178
dc.identifier.issn2149-8296
dc.identifier.issue3
dc.identifier.startpage173
dc.identifier.trdizinid414980
dc.identifier.urihttps://doi.org/10.18663/tjcl.432886
dc.identifier.urihttps://search.trdizin.gov.tr/tr/yayin/detay/414980
dc.identifier.urihttps://hdl.handle.net/20.500.12587/23086
dc.identifier.volume9
dc.indekslendigikaynakTR-Dizin
dc.language.isoen
dc.relation.ispartofTurkish Journal of Clinics and Laboratory
dc.relation.publicationcategoryMakale - Ulusal Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/openAccess
dc.snmzKA_20241229
dc.subjectTıbbi Araştırmalar Deneysel
dc.subjectGenel ve Dahili Tıp
dc.subjectSağlık Bilimleri ve Hizmetleri
dc.titleClinical use of specific markers TAS, TOS, PON and IL-6 by the evaluation of kidney damage in patients receiving SWL treatment
dc.typeArticle

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