PROTECTIVE EFFECTS OF KETOPROFEN ON OXIDATIVE STRESS AND HISTOPATHOLOGICAL CHANGES IN TESTICULAR ISCHEMIA-REPERFUSION INJURY IN A RAT

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dc.authoridOgus, Elmas/0000-0003-3844-2173
dc.authoridAydos, Tolga Resat/0000-0002-1832-9336
dc.authoridcakan, turkay/0000-0001-9415-9650
dc.contributor.authorCakan, Murat
dc.contributor.authorCakan, Turkay
dc.contributor.authorAydos, Tolga
dc.contributor.authorYilmazer, Demet
dc.contributor.authorOgus, Elmas
dc.contributor.authorKilic, Aytun S.
dc.date.accessioned2025-01-21T16:43:48Z
dc.date.available2025-01-21T16:43:48Z
dc.date.issued2007
dc.departmentKırıkkale Üniversitesi
dc.description.abstractIntroduction: Testicular torsion is a common surgical emergency affecting newborns, children and adolescents. A possible cause of testicular injury is ischemia-reperfusion (I/R) injury. In this study we evaluated the effect of ketoprofen, a non-steroidal anti-inflammatory drug, on I/R injury due to testicular torsion-detorsion (T/D). Materials and Methods: Twenty-eight prepubertal male Wistar rats were divided into four groups each containing 7 rats: Group 1, control; Group 2, sham; Group 3, T/D; and Group 4, T/D+ketoprofen. Group 3 and 4 underwent 2 hours of left testicular torsion and 4 hours of detorsion. In Group 4, ketoprofen (5 mg/kg) was administrated intraperitoneally 60 minutes before detorsion. At the end of the study, bilateral orchiectomies were performed for measurement of MDA and NO levels and histopathologic examination. Results: Testicular torsion-detorsion significantly induced oxidative stress and tissue damage in both ipsilateral and contralateral testes. Administration of ketoprofen significantly lowered MDA level and improved histologic parameters of spermatogenesis in both testes. Conclusion: Ketoprofen has a protective effect on testicular ischemia-reperfusion injury due to testicular torsion/detorsion.
dc.identifier.endpage55
dc.identifier.issn2149-3235
dc.identifier.issn2149-3057
dc.identifier.issue1
dc.identifier.startpage50
dc.identifier.urihttps://hdl.handle.net/20.500.12587/25333
dc.identifier.volume33
dc.identifier.wosWOS:000420465000008
dc.identifier.wosqualityN/A
dc.indekslendigikaynakWeb of Science
dc.language.isotr
dc.publisherAves
dc.relation.ispartofTurkish Journal of Urology
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.snmzKA_20241229
dc.subjectTestis; Ischemia-reperfusion injury; Ketoprofen
dc.titlePROTECTIVE EFFECTS OF KETOPROFEN ON OXIDATIVE STRESS AND HISTOPATHOLOGICAL CHANGES IN TESTICULAR ISCHEMIA-REPERFUSION INJURY IN A RAT
dc.typeArticle

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