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Öğe Effect of psychological on respiratory symptoms(2005) Ekici, Aydanur; Oğuztürk, Ömer; Ekici, Mehmet; Kurtipek, Ercan; Akın, Ahmet; Arslan, Mesut; Tunçkol, MügeAmaç: Psikolojik durumun solunum semptomu bildirmeye ve solunum sisteminin objektif ölçümlerine etkisinin olup olmadığını araştırdık. Materyal ve Metotlar: Çalışmaya silah fabrikasında çalışan 1090 erkek işçi ve biomasse maruz kalan 420 kadın alındı. Olgular respiratuar sorgulama formu ile sorgulanarak portable spirometre cihazı ile solunum fonksiyonları ölçüldü.Psikolojik durum HAD scalası ile ölçülerek ;median değere göre yüksek ve düşük HAD total skorlu gruplar olarak sınıflandırıldılar. Bulgular: Erkeklerde: Kronik öksürük (%17,6 vs %10,7 p0,001), Kronik balgam (13,2% vs.8,9%, p0,02) ve muhtemel astım (%39,5 vs %25,5, p0,0001) yüksek HAD total skorlu grupta düşük HAD total skorlu grupa göre önemli olarak daha sık bulunurken kesin astım (%6,2 vs %4,6, p0,2) için gruplar arasında fark yoktu. Kadınlarda: Kronik öksürük (%34,8 vs %23,5 p0,009), kronik balgam (%23,9 vs. %15,4, p0,02) ve muhtemel astım (%53,5 vs %35,3, p0,0001) yüksek HAD total skorlu grupta düşük HAD total skorlu grupa göre önemli olarak daha sık bulunurken kesin astım (%7,0 vs %9,0, p0,4) için gruplar arasında fark yoktu. Sonuç: Respiratuar sorgulamada semptom bildirme sıklığı psikolojik durumdan etkilenebilir.Respiratuar sorgulama ve psikolojik durum göstergeleri eşzamanlı olarak yorumlanmalıdır.Öğe EFFECT OF PSYCHOLOGICAL STATUS ON RESPIRATORY SYMPTOMS(Gazi Univ, Fac Med, 2005) Ekici, Aydanur; Oguzturk, Omer; Ekici, Mehmet; Kurtipek, Ercan; Akin, Ahmet; Arslan, Mesut; Kara, TurkanObjective: To investigate whether psychological status affects respiratory symptom reporting and objective measures of the respiratory system. Materials and Methods: This study was performed in 1090 male gun factory workers and in 420 women exposed to biomass. The subjects were questioned using a Respiratory questionnaire. Respiratory functions were measured by portable spirometer. Psychological status was measured by HAD scale. Groups with high HAD total scores and low HAD total scores were classified by the median value. Results: In males: Chronic cough (17.6% vs. 10.7% p=0.001), chronic phlegm (13.2% vs. 8.9%, p=0.02), and probable asthma (39.5% vs. 25.5%, p=0.0001) were significantly more frequent in the group with high HAD total scores than in the group with low HAD total scores but definite asthma was not (6.2% vs. 4.6%, p=0.2). In women: Chronic cough (34.8% vs. 23.5% p=0.009), chronic phlegm (23.9% vs. 15.4%, p=0.02), and probable asthma (53.5% vs. 35.3%, p=0.0001) were significantly more frequent in the group with high HAD total scores than in the group with low HAD total scores but definite asthma was not (7.0% vs. 9.0%, p=0.4). Conclusion: Psychological status might affect the frequency of symptom reporting in respiratory questionnaires. The questionnaires and psychological status indices should be interpreted simultaneously.Öğe Kronik hava yolu hastalıklarında karbonmonoksit difüzyon değerleri(2009) Bulcun, Emel; Ekici, Aydanur; Şentürk, Erol; Arslan, Mesut; Akın, Ahmet; Ekici, MehmetKarbonmonoksit difüz yon (DLCO) ölçümü pulmoner gaz değişimi hakkında bilgi veren önemli ve kullanışlı noninvaziv bir testtir. Biz kronik hava yolu hastalıklarından astım, kronik obstrüktif akciğer hastalığı (KOAH) ve bronşektazi tanılı hastalarda difüzyon değerleri ile hastalık derecesi arasındaki ilişkiyi ve difüzyon değerlerini belirleyen faktörleri araştırdık. Çalışmaya astım tanılı 64, KOAH tanılı 78 ve bronşektazi tanılı 41 olmak üzere toplam 183 hasta ile sigara içmeyen 43 sağlıklı birey alındı. Atak döneminde olan 10 astımlı hasta hariç tüm hastalar stabil dönemde idi. Tüm olgulara solunum fonksiyon testi ve DLCO testi yapıldı. KOAH grubunda DLCO% ve DLCO/VA% değerleri astım, bronşektazi ve kontrol grubundan düşük bulundu (p0.001). Astımlı hastalarda atak döneminde DLCO% değeri; kontrol grubu, stabil dönemdeki orta ve ağır persistan astımlılardan yüksek bulundu (p0.05). Ağır persistan astımlılarda DLCO% değeri ise hafif persistan astımlılardan düşük bulundu (p0.05). Tüm hasta ve kontrol grubu birlikte değerlendirildiğinde, DLCO% ile FEV1% (r 0.49; p 0.0001), FEV1/FVC (r 0.36; p 0.0001) arasında ve DLCO/VA% ile FEV1% (r 0.16; p 0.01), FEV1/FVC (r 0.26; p 0.0001) arasında pozitif ilişki bulundu. Kronik hava yolu hastalıklarında DLCO kapasitesi obstrüksiyona paralel olarak azalmaktadır. DLCO değerleri kronik hava yolu hastalıklarının değerlendirilmesinde ve hastalık şiddetinin belirlenmesinde kullanılabilir.Öğe Kronik obstrüktif akciğer hastalığında kemik mineral dansitesi(Kırıkkale Üniversitesi, 2004) Arslan, Mesut; Ekici, Mehmet SavaşIV ÖZET Arslan M., Kronik obstrüktif akciğer hastalığında kemik mineral dansitesi, Kırıkkale Üniversitesi Tıp Fakültesi Göğüs Hastalıkları ve Tüberküloz Ânabilim Dalı Uzmanlık Tezi, Kırıkkale 2004. Bu tezin amacı KOAH tanısı konulan hastalarda kemik mineral yoğunluğuna etki edebilecek faktörleri belirlemektir. Bu amaçla 40 yaş ve üzeri KOAH'lı 63 hasta (Grup I) ve kronik bronşit' li 35 hasta (Grup II) ile kontrol grubu olarak 40 yaş ve üzeri steroid tedavisi almamış, sigara içmemiş 41 gönüllü (Grup III) çalışmaya dahil edildi. Çalışmaya katılanların hepsi erkekti. KOAH ve kronik bronşitti hastalar ve gönüllü kontrol grubundakiler fiziksel aktivite, beslenme ve kortikosteroid kullanımı öyküsü yönünden sorgulanıp, antropometrik, biyokimyasal ve hormonal değerlendirmeye tabi tutuldular. Solunum fonksiyon testleri ve kemik mineral dansiteleri (Antero-posterior lumbal ve lateral femoral) ölçüldü. Grup I ile Grup n'nin femur boynu T- skoru ve Z- skoru, Grup ni'den anlamlı olarak düşüktü (p=0.008 ve p=0.043). Grup I' deki hastaların vücût ağırlıkları, beden kitle endeksleri, kol ortası çevresi, kol ortası kas çevresi ve albumin seviyeleri Grup II ve Grup IlI'ten anlamlı olarak düşüktü (p-0.004, p-0.009, p=0.011, p=0.010 ve p=0.017). Tüm grupların seram DHEA-S seviyeleri femur boynu T-skoru ve femur boynu kemik mineral yoğunluğu (p=0.045, p=0.024) ile Serbest androjen endeksi ise lumbal T-skoru, lumbal Z-skora ve lumbal vertebra kemik mineral yoğunluğu ile ilişkili idi (p=0.020, p=0.014 ve p=0.016). Hiçbir steroid preperatı kullanmayan Grup I ve Grup IF deki hastalarınfemur boynu T-skorlan, Z- skorları ve kemik mineral yoğunlukları kullananlardan anlamlı olarak yüksekti (p=0.006, p=0.010 ve p=0.006). Grup Fdeki hastalann femur boynu T-skorlan Grup IFdekilerden anlamlı olarak düşüktü (p=0.047). Sonuç olarak beden kitle endeksi, sigara paket/yılı ve sistemik steroid kullanımı KOAH'lı hastalarda kemik mineral yoğunluğuna etki eden en önemli faktörlerdir. Anahtar Kelimeler: KOAH, osteoporoz, sigara, beden kitle endeksi, kortikosteroid.Öğe Obstructive airway diseases in women exposed to biomass smoke(Academic Press Inc Elsevier Science, 2005) Ekici, Aydanur; Ekici, Mehmet; Kurtipek, Ercan; Akın, Ahmet; Arslan, Mesut; Kara, Türkan; Demir, SelmaThe majority of women living in rural areas in Turkey use biomass fuels for domestic energy and are exposed to high levels of indoor air pollution every day. The objective of this study was to compare the presence of chronic airway diseases (CAD) in two groups of nonsmoking women older than 40 years with (exposed group, n = 397) and without a history of exposure to biomass cooking (liquid petroleum gas (LPG); control group, n = 199), in 2002 in Kirikkale, Turkey. Detailed respiratory symptoms were collected with a standard questionnaire adapted from that of the British Medical Research Council. Exposure was calculated as the average hours spent daily for cooking multiplied by the number of years. CAD were defined as either chronic airway obstruction (CAO; (forced expiratory volume in 1 s/forced vital capacity) < 0.70), chronic bronchitis, or chronic bronchitis with CAO. The prevalence of CAD in the exposed group was found to be higher than that in the LPG group (28.5% vs. 13.6%, crude odds ratios (ORs) 2.5 (1.5-4.0), P = 0.0001). The fraction of CAD attributed to exposure to biomass smoke after adjusting for possible confounding factors was 23.1% (95% confidence interval (CI) 13.4-33.2). Acute symptoms during exposure to biomass smoke were important predictors for the presence of CAD. Biomass smoke pollution is an important contributing factor in the development of CAD in nonsmoking women living in a rural area. The presence of acute symptoms during cooking in women in rural areas should signal to general practitioners the possibility of CAD. (c) 2005 Elsevier Inc. All rights reserved.Öğe Psychological status and quality of life in elderly patients with asthma(Elsevier Science Inc, 2005) Oğuztürk, Ömer; Ekici, Aydanur; Kara, Murat; Ekici, Mehmet; Arslan, Mesut; Iteginli, Ahmet; Kurtipek, ErcanThe psychological status and quality of life of 70 stable patients with asthma age greater than or equal to60 years and 40 age-matched comparison subjects were examined. The patients with long-standing asthma (duration greater than or equal to 8 years) had lower quality-of-life scores than those with recent-onset asthma (duration < 8 years). In multivariate linear regression analysis with adjustment for age, gender, duration of disease, and level of bronchial hyperreactivity, worse quality of life was predicted by anxiety, depression, and asthma severity scores. In elderly patients with long-standing asthma, disease severity significantly impairs quality of life. Impaired quality of life in these patients may be partly related to psychological status indicators.Öğe Quality of Life and Bronchial Hyper-Responsiveness in Subjects With Bronchiectasis: Validation of the Seattle Obstructive Lung Disease Questionnaire in Bronchiectasis(Daedalus Enterprises Inc, 2015) Bulcun, Emel; Arslan, Mesut; Ekici, Aydanur; Ekici, MehmetBACKGROUND: Bronchiectasis can adversely affect quality of life. However, the tests examining quality of life in bronchiectasis are not sufficient. We examined the validity of a measure designed for COPD, the Seattle Obstructive Lung Disease Questionnaire (SOLQ), in bronchiectasis. In addition, we aimed to compare the quality of life of subjects with bronchiectasis and bronchial hyper-responsiveness with that of those without to identify the effective factors. METHODS: We studied 78 subjects with clinically stable bronchiectasis and 41 healthy controls matched for age and sex. Subjects were assessed by the SOLQ. A detailed history, physical examination, the Medical Outcomes Study 36-Item Short Form questionnaire, the Hospital Anxiety and Depression Scale, and spirometric measurements were obtained. RESULTS: Cronbach alpha coefficients, which reflected internal consistency, were >0.70 for all SOLQ components except for treatment satisfaction. SOLQ component scores correlated with all of the component scores of the Medical Outcomes Study 36-Item Short Form questionnaire and the Hospital Anxiety and Depression Scale, confirming their concurrent validity. All SOLQ scores correlated positively with percent-of-predicted FEV1, whereas the physical function, treatment satisfaction, and emotional function correlated negatively with the exacerbation frequency in Pearson analysis. Emotional and physical functions were positively associated with percent-of-predicted FEV1 in linear regression analysis. Compared with subjects without bronchial hyper-responsiveness, those with bronchial hyper-responsiveness had lower FEV1/FVC and more exacerbations/y. Compared with bronchiectasis subjects without bronchial hyper-responsiveness, those with bronchial hyper-responsiveness had significantly lower SOLQ, physical function, and coping skills scores but not emotional function and treatment satisfaction. CONCLUSIONS: The SOLQ is a valid instrument for determining quality of life in subjects with bronchiectasis. Subjects with bronchiectasis and bronchial hyper-responsiveness had a poorer quality of life, lower baseline spirometric values, and more frequent exacerbations, suggesting more severe disease.Öğe Respiratory findings in gun factory workers exposed to solvents(W.B. Saunders Ltd, 2004) Çakmak, Aytül; Ekici, Aydanur; Ekici, Mehmet; Arslan, Mesut; İteginli, Ahmet; Kurtipek, Ercan; Kara, TürkanObjective: Gun factory workers are exposed to many solvents (toluene, acetone, butanol, xylene, benzene, trichloroethylene). We investigated whether chronic exposure to solvents had adverse effect on respiratory system. Material and methods: The workers were questionnaired by modified Medical Research Council's respiratory questionnaire before morning start shift. Then physical examination and measurement of pulmonary functions by portable dry rolling spirometer were performed. The study group consisted of 1091 gun factory workers. The workers were grouped according to their smoking habits (smokers, [exposed n: 353 vs. unexposed n: 339] and non-smokers [exposed n: 58 vs. unexposed n: 341]). Asthma-related symptoms were defined as either definite asthma, probable asthma, and possible asthma. Results: In non-smokers, the report of asthma-related symptoms was more prevalent in exposed workers than unexposed (39.7% vs. 21.7% OR 2.4[l.3-4.3], respectively P=0.003). In smokers, the report of asthma-related symptoms was more common in exposed group than unexposed (50.7% vs. 42.5% OR 1.4[l.0-1.9], respectively P=0.03). Logistic regression analysis showed that smoking (OR 2.8 [2.0-3.8] P=0.00001) and exposure to solvents (OR 1.4[l.1-1.9] P=0.01) were independent risk factors for asthma-related symptoms, after adjusting for age. Logistic regression analysis identified that smoking (OR 3.3[2.3-4.6] P=0.00001) was independent risk factors for chronic bronchitis. Multiple linear regression analysis of lung-function parameters (% forced expiratory volume (FEV1), FEV1/forced vital capacity, FEF25-75) indicated significant effects of smoking. Conclusion: Present study indicated significant effects of smoking and exposure to solvents, with the smoking effect being the most important on asthma-related symptoms of gun factory workers. © 2003 Elsevier Ltd. All rights reserved.
