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Öğe The Adjunctive Effect of Platelet-Rich Fibrin to Connective Tissue Graft in the Treatment of Buccal Recession Defects: Results of a Randomized, Parallel-Group Controlled Trial(Wiley, 2015) Keçeli, Hüseyin Gencay; Kamak, Gülen; Erdemir, Ebru Olgun; Evginer, Mustafa Serdar; Dolgun, AnılBackground: Platelet-rich fibrin (PRF) is an autologous preparation that has encouraging effects in healing and regeneration. The aim of this trial is to evaluate the effectiveness of coronally advanced flap (CAF) + connective tissue graft (CTG) + PRF in Miller Class I and II recession treatment compared to CAF + CTG. Methods: Forty patients were treated surgically with either CAF + CTG + PRF (test group) or CAF + CTG (control group). Clinical parameters of plaque index, gingival index, vertical recession (VR), probing depth, clinical attachment level (CAL), keratinized tissue width (KTW), horizontal recession (HR), mucogingival junction localization, and tissue thickness (TT) were recorded at baseline and 3 and 6 months after surgery. Root coverage (RC), complete RC (CRC), attachment gain (AG), and keratinized tissue change (KTC) were also calculated. Results: All individuals completed the entire study period. At baseline, mean VR, HR, CAL, KTW, and TT values were similar (P > 0.05). In both groups, all parameters showed significant improvement after treatment (P < 0.001), and except TT (P < 0.05), no intergroup difference was observed at 6 months after surgery. The amount of RC and AG, but not KTC and CRC, was higher in the PRF-applied group (P < 0.05). Conclusions: According to the results, the addition of PRF did not further develop the outcomes of CAF + CTG treatment except increasing the TT. However, this single trial is not sufficient to advocate the true clinical effect of PRF on recession treatment with CAF + CTG, and additional trials are needed.Öğe Advanced oxidation protein products and monocyte chemoattractant protein-1 in periodontal disease(2018) Hendek, Meltem Karşıyaka; Erdemir, Ebru Olgun; Kısa, ÜçlerAim: The aim of the study was to determine gingival crevicular fluid (GCF) levels of advanced oxidation protein product(AOPP) and monocyte chemoattractant protein (MCP)-1 in subjects with periodontal disease and health.Materials and Methods: A total of 75 non-smokers, including 25 participants with chronic periodontitis (CP), 25participants with gingivitis (G) and 25 participants with periodontally healthy (H) were included into the present study.The probing depth (PD), clinical attachment level (CAL), plaque index (PI) and gingival index (GI) were recorded. The GCFsamples from 4 sites in each individual were collected and GCF AOPP and MCP-1 levels were determined by enzymelinked immunosorbent assay method.Results: GCF AOPP and MCP-1 levels were the lowest in the H group; followed by the G group and the highest in the CPgroup. These differences were statistically significant between G and H groups and between the CP and the other groups(p <.05). A statistically positive correlation was detected between GCF AOPP and MCP-1 levels.Conclusion: GCF AOPP and MCP-1 levels might play a considerable role during periodontal inflammation and an elevatedGCF AOPP and MCP-1 levels are suggested as a potential biomarker for periodontal diseases.Öğe Assessment Of Knowledge And Attitudes Toward Periodontal Health Among Parents Of Pediatric Dentistry Patients(2019) Hendek, Meltem Karşıyaka; Almaz, Merve Erkmen; Bezirci, Didem; Erdemir, Ebru OlgunAim: Family is the most important environment wherechildren acquire knowledge, attitudes, and habitsrelated to oral health. The aim of this study was toevaluate the knowledge and attitudes of parentstoward periodontal health and diseases, and therelationship of their knowledge and attitudes withdemographic data.Materials and Methods: 500 parents, referred forthe treatment of their children were included in thestudy. The knowledge and attitudes of the parentswere assessed using a self-administered and structuredquestionnaire. Data were analyzed by chi-squaretest, with the level of significance set at p0.05.Results: 33.0% parents and 33.6% children brushedtheir teeth twice or more daily. 17% parents and 8.6%children used dental floss/interdental brush, and 77%parents visited a dentist only when they experienceddental complaints. Most parents incorrectly definedthe meaning of dental plaque and did not know itsrole in the etiology of gingival diseases. 47.4% ofthem were aware that bleeding gums indicated thepresence of periodontal disease, while only 11.8%knew that one of the main reasons of tooth loss wasperiodontal disease. It was also evident that the useof dental floss significantly increased with an increasein income level (p0.05), and the knowledge andattitude of the parents regarding periodontal healthsignificantly increased with the educational level(p0.05).Conclusion: The knowledge and attitude of theparents regarding periodontal health were poor. Thus,an improvement in the knowledge and awarenessamong the parents can prevent or reduce the severityof possible periodontal problems in their children.Öğe The detection of salivary minerals in smokers and non-smokers with chronic periodontitis by the inductively coupled plasma-atomic emission spectrophotometry technique(Wiley, 2006) Erdemir, Ebru Olgun; Erdemir, AliBackground: The purpose of this study was to evaluate the effect of smoking on the salivary minerals in subjects with chronic periodontitis by the inductively coupled plasma-atomic emission spectrophotometry (ICP-AES) technique. Methods: The study group included 24 subjects - 12 smokers and 12 non-smokers-with chronic periodontitis. Clinical measurements and non-stimulated whole saliva were obtained, and the levels of five elements-sodium, potassium, calcium, magnesium, and phosphate-in each specimen were analyzed. Results: When the clinical parameters were compared between groups, only plaque index was significantly higher in smokers than non-smokers (P < 0.05). The mean plaque index of smokers and non-smokers was 1.93 +/- 0.51 and 1.51 +/- 0.39, respectively. The results of this study showed that there were no significant differences between groups in the mineral content of saliva. In smokers, there were positive correlations between the levels of calcium, sodium, and magnesium and clinical attachment level. There was also a positive correlation between the level of phosphate and the percentage of bleeding on probing. In non-smokers, there was a negative correlation only between the mean level of sodium and plaque index (P < 0.05). Conclusions: The present study showed that no significant differences were found between the mineral content of saliva of smokers and non-smokers by the ICP-AES technique. It is a useful, fast, and sensitive technique compared to other techniques, and it can be advised for researchers while analyzing the mineral content of saliva.Öğe Effect of Initial Periodontal Therapy on Oxidative Stress Markers in Gingival Crevicular Fluid, Saliva, and Serum in Smokers and Non-Smokers With Chronic Periodontitis(Wiley, 2015) Hendek, Meltem Karsiyaka; Erdemir, Ebru Olgun; Kisa, Ucler; Ozcan, GonenBackground: The aim of this case-control study with an intervention arm is to determine the effect of initial periodontal treatment on oxidative stress biomarkers in smokers and non-smokers with chronic periodontitis (CP). Methods: The study included 47 patients with CP (24 smokers [S+ P+] and 23 non-smokers [S-P+]) and 46 periodontally healthy individuals (23 smokers [S+ P-] and 23 non-smokers [S-P-]) for a total of 93 participants. Gingival crevicular fluid (GCF), serum, and saliva samples were obtained and clinical periodontal measurements were recorded at baseline and at the first and third months after periodontal therapy. 8-hydroxydeoxyguanosine (OHdG) and 4-hydroxynonenal (HNE) and enzyme activity of glutathione peroxidase (GSH-Px) were analyzed with enzyme-linked immunosorbent assay. Results: The level of 8-OHdD in GCF was found to be significantly higher in both periodontitis groups compared with both periodontally healthy groups. 8-OHdG and GSH-Px in saliva in both periodontitis groups were significantly increased compared with the S-P-group. In the S+ P+ group, 4-HNE in GCF was found to be significantly higher than in periodontally healthy participants. After initial periodontal treatment, the levels of 8-OHdG in GCF and saliva were significantly decreased in both periodontitis groups. Conclusion: Initial periodontal therapy may be helpful for diminishing oxidative stress in periodontitis.Öğe Effect of smoking on folic acid and vitamin B-12 after nonsurgical periodontal intervention(Wiley, 2007) Erdemir, Ebru Olgun; Bergstrom, JanAim: The main purpose of this study was to investigate the effect of smoking on the serum levels of folic acid and vitamin B-12 in smokers and nonsmokers with chronic periodontal disease after nonsurgical intervention. Material and Methods: The study base consisted of 45 current smokers and 43 nonsmokers. The clinical parameters included plaque index (PI), gingival index (GI), pocket depth (PD), and clinical attachment level (CAL). Folic acid and vitamin B-12 were determined from peripheral blood samples. Clinical measurements and blood samples were collected at baseline and 1, 3, and 6 months after the intervention. Results: Mean PI was significantly greater in smokers compared with non-smokers throughout the observation period (p < 0.001). During the first month, GI levels significantly decreased in both groups. From months 1 through 6, a significant return towards an increased GI level was observed in smokers (p < 0.001). PD and CAL levels significantly decreased during the first month in both groups. Thereafter, increasing levels of PD and CAL were seen in both groups, although significantly more pronounced in smokers. Throughout the observation period, the mean CAL was significantly greater in smokers relative to nonsmokers (p < 0.001). In smokers, the mean folic acid level gradually and significantly decreased and a slight and significant decrease in mean vitamin B-12 levels was observed in both groups over the entire observation period (p < 0.001). Conclusion: The clinical response to nonsurgical intervention is impaired by smoking and smoking seems to negatively influence the serum level of folic acid following non-surgical intervention.Öğe Evaluation of Salivary Procalcitonin Levels in Different Periodontal Diseases(Amer Acad Periodontology, 2015) Hendek, Meltem Karsiyaka; Erdemir, Ebru Olgun; Kisa, UclerBackground: The present study aims to investigate the levels of salivary procalcitonin (ProCT) in patients with different periodontal diseases. Methods: Seventy-two non-smokers are included in this study: 21 individuals with chronic periodontitis (CP), 14 individuals with generalized aggressive periodontitis (GAgP), 18 individuals with gingivitis (G), and 19 periodontally healthy (H) participants. Clinical periodontal parameters, including probing depth (PD), clinical attachment level (CAL), plaque index, and gingival index (GI), were assessed in all participants. Saliva samples were collected and examined for evaluating ProCT levels. Results: It was found that the median (interquartile range) salivary ProCT level was lowest in the H group: 0.00 (0.09) ng/mL; followed by the G group: 0.09 (0.11) ng/mL; the CP group: 0.15 (0.29) ng/mL; and highest in the GAgP group 0.28 (0.68) ng/mL. These differences were statistically significant between the H group and the other groups (P <0.05). There were positive correlations between the mean salivary ProCT level and GI, CAL, and PD. Conclusion: According to the present results, ProCT might play a role during periodontal inflammation, and an elevated salivary ProCT level is suggested as a potential biomarker for periodontal diseases.Öğe Evaluation of the oral health status of the people aged 65 years and over living in near rural district of Middle Anatolia, Turkey(Elsevier Ireland Ltd, 2007) Nalcaci, Rana; Erdemir, Ebru Olgun; Baran, İlgiThe aim of this study was to assess the oral health status of aged 65 years and over, and evaluate the level of edentulousness and study the factors that could have an influence on edentulism. The participants of this study were 215 patients; 94 males (47.3%) and 121 females (56.3%), aged 65 years and over. Each subject underwent a comprehensive dental and radiographic examination by one examiner. Periodontal attachment loss observed in the panoramic radiographs was divided into three diagnostic categories: infrabony defects, horizontal bone loss, and furcation lesions. The number of teeth with apical periodontitis lesions, the number of carious teeth, and restorations, type of dentures and wear duration, intrabony root remains, impacted teeth, smoking status, educational level and self-reported medical history of the participants were recorded. Extent of tooth loss was significantly higher in females than males and increased with increasing age (p < 0.05). Tooth loss was significantly associated with educational levels; lower literacy level was found to be associated with a higher number of missing teeth (p < 0.01). Also, as the educational levels of the participants increased, the number of infrabony defects, furcation lesions and number of carious teeth decreased (p < 0.05). Low literacy level and female gender are found to be high-risk groups for tooth loss. Community-based oral disease prevention programs should be implemented to reduce the risk for tooth loss in this population. (C) 2006 Elsevier Ireland Ltd. All rights reserved.Öğe Interleukin (IL)-17F (H161R) and IL-23R (R381Q) Gene Polymorphisms in Turkish Population with Periodontitis(Amber Publication, 2015) Erdemir, Ebru Olgun; Hendek, Meltem Karsiyaka; Kocakap, Derya Beyza Sayin; Ozkan, Serdar YucelBackground: Periodontitis is triggered by periodontal pathogens and influenced by environmental and genetic factors. Genes encoding molecules related to the immune response are the main candidates for polymorphisms analysis and may be possibly associated with this pathology. Aim: The aim of the study was to evaluate the interleukin (IL)-17F Histidine161Arginine (H161R) and IL-23R Arginine381Glycine (R381Q) gene polymorphisms in patients with periodontitis in Turkish population. Materials and Methods: 90 periodontally healthy, 90 patients with chronic periodontitis and 57 patients with generalized aggressive periodontitis were included in the study. Participants were identified through clinical examinations and radiographs. DNA was isolated from venous blood samples from each patient and genotype analyses were made for single nucleotide polymorphisms (SNPs). Data were analyzed using the x(2) test. Results: The comparison of allelic, genotypic frequencies of the IL-17F (H161R) and IL-23R (R381Q) polymorphisms revealed no significant differences between the periodontally healthy individuals and patients with periodontal diseases. Conclusion: On the basis of the present findings, it can be suggested that IL-17F gene (H161R) and IL-23R gene (R381Q) polymorphisms are not associated with the susceptibility to periodontitis in Turkish population.Öğe Orthodontic movement of a horizontally fractured tooth: a case report(Blackwell Munksgaard, 2005) Erdemir, Ali; Ungor, Mete; Erdemir, Ebru OlgunIntra-alveolar root fractures are relatively uncommon, and sometimes may be healed without treatment. Diagnosis of intra-alveolar root fracture is frequently made by exclusion of clinical signs of other traumatic injury, and by radiographic examination with films taken at different tube angulations. This case report presents a horizontal root fractured tooth that was healed satisfactory without treatment and moved orthodontically after prolonged time from trauma.Öğe Periodontal health in children exposed to passive smoking(Wiley, 2010) Erdemir, Ebru Olgun; Sönmez, Isil Saroglu; Oba, Aylin Akbay; Bergstrom, Jan; Çağlayan, OsmanP>Aim To determine (1) the cotinine levels of saliva, urine and gingival crevicular fluid (GCF) of children in families with and without smoking members and (2) a possible association between the periodontal health of the children and exposure to passive smoking. Material and Methods The study population comprised of 109 children in the age range 6-12 years. Children were classified as exposed to passive tobacco smoking (PTS-exposed, n=51) and as unexposed controls (PTS-unexposed, n=58). Plaque index, gingival index, bleeding on probing, probing depth and clinical attachment level (CAL) were recorded. GCF, saliva and urine samples were also collected. The levels of cotinine in these fluids were determined by enzyme-linked immunosorbent assay. Results The mean salivary cotinine concentration was significantly increased in PTS-exposed children compared with PTS-unexposed children (p < 0.05). Further, in a dose-dependent way, the mean salivary concentration was significantly higher in children whose father or mother was a smoker (p < 0.05) as compared, respectively, with children whose fathers and mothers were non-smokers. The mean CAL was significantly less in PTS-exposed children compared with non-PTS-exposed children (0.09 mm; p < 0.05) and also in children whose father was a smoker (p < 0.05), but not in children whose mother was a smoker as compared with non-smoker fathers and mothers, respectively. The GCF cotinine levels were below the detection limits with the assay method that was used. Conclusions We have observed that children who are exposed to passive smoking have elevated cotinine levels in their saliva concomitant with a lowered CAL.Öğe PERİODONTİTİS VE DİABETES MELLİTUS: ÇİFT YÖNLÜ İLİŞKİ(2017) Acıpınar, Şükran; Hendek, Meltem Karşıyaka; Erdemir, Ebru OlgunPeriodontitis ve diabetes mellitus (DM) toplumda yaygın görülen kronik hastalıklardır. Periodontitis bakteriyel plak ve konak immün yanıtı arasındaki dengenin bozulmasından kaynaklanan dişlerin destek dokularının (periodontal ligament ve kemik) yıkımıyla karakterize diş kaybıyla sonuçlanabilen kronik inflamatuar bir durumdur. Diabetes mellitus insülin hormon sekresyonunun yokluğu / yetersizliği veya insülin direnci ile karakterize çeşitli komplikasyonlarla kendini gösteren karbonhidrat, yağ ve protein metabolizma bozukluğu hastalığıdır. Periodontitis son dönemlerde diyabetin klasik komplikasyonlarından biri halini almıştır. Epidemiyolojik veriler diyabetin periodontitis için majör risk faktörü olduğunu ve diyabetiklerin diyabetik olmayanlara göre periodontitise daha yatkın olduğunu göstermektedir. Bu iki kronik hastalık arasında karşılıklı ilişki olduğu bilinmektedir. Çeşitli hücresel, immünolojik yolların ve sitokinlerin rolü olduğu belirlenmiş olsa da mekanizma halen tam olarak anlaşılamamıştır.Öğe Relationship between smoking and folic acid, vitamin B-12 and some haematological variables in patients with chronic periodontal disease(Wiley, 2006) Erdemir, Ebru Olgun; Bergstrom, JanAim: The purpose of this study was to investigate the relationship between cigarette smoking and the serum levels of folic acid, vitamin B-12 and some haematological variables in patients with periodontal disease. Patients and methods: The study base consisted of 88 volunteer patients with periodontal disease, including 45 current smokers in the age range 31-68 years and 43 non-smokers in the range 32-66 years. The clinical parameters included plaque index (PI), gingival index (GI), bleeding on probing (BOP), probing depth (PD) and clinical attachment loss (CAL). Folic acid, vitamin B-12 and haematological variables were determined from peripheral blood samples. Results: PI, PD and CAL means were significantly higher in smokers than nonsmokers (p < 0.05). The serum folic acid concentration of smokers was lower than that of non-smokers (p < 0.05), whereas the white blood cell count was higher in smokers than in non-smokers (p < 0.05). Conclusion: The results of this study suggest that among patients with periodontal disease the serum folic acid concentration is lower in smokers compared with non-smokers.
