Interleukin (IL)-17F (H161R) and IL-23R (R381Q) Gene Polymorphisms in Turkish Population with Periodontitis
Yükleniyor...
Tarih
2015
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
Amber Publication
Erişim Hakkı
info:eu-repo/semantics/openAccess
Özet
Background: Periodontitis is triggered by periodontal pathogens and influenced by environmental and genetic factors. Genes encoding molecules related to the immune response are the main candidates for polymorphisms analysis and may be possibly associated with this pathology. Aim: The aim of the study was to evaluate the interleukin (IL)-17F Histidine161Arginine (H161R) and IL-23R Arginine381Glycine (R381Q) gene polymorphisms in patients with periodontitis in Turkish population. Materials and Methods: 90 periodontally healthy, 90 patients with chronic periodontitis and 57 patients with generalized aggressive periodontitis were included in the study. Participants were identified through clinical examinations and radiographs. DNA was isolated from venous blood samples from each patient and genotype analyses were made for single nucleotide polymorphisms (SNPs). Data were analyzed using the x(2) test. Results: The comparison of allelic, genotypic frequencies of the IL-17F (H161R) and IL-23R (R381Q) polymorphisms revealed no significant differences between the periodontally healthy individuals and patients with periodontal diseases. Conclusion: On the basis of the present findings, it can be suggested that IL-17F gene (H161R) and IL-23R gene (R381Q) polymorphisms are not associated with the susceptibility to periodontitis in Turkish population.
Açıklama
Anahtar Kelimeler
Periodontitis, cytokines, polymorphism, interleukin-17F, interleukin-23R
Kaynak
Journal Of Research In Medical And Dental Science
WoS Q DeÄŸeri
N/A
Scopus Q DeÄŸeri
Cilt
3
Sayı
2
Künye
Olgun, Ebru & Hendek, Meltem & Sayin, Derya & Kocakap, Sayin & Ozkan, Yucel & Professor, Assistant. (2015). Interleukin (IL)-17F (H161R) and IL-23R (R381Q) Gene Polymorphisms in Turkish Population with Periodontitis. Journal of Research in Medical and Dental Science. 3(2), 104-108.
