Interleukin (IL)-17F (H161R) and IL-23R (R381Q) Gene Polymorphisms in Turkish Population with Periodontitis

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dc.contributor.authorErdemir, Ebru Olgun
dc.contributor.authorHendek, Meltem Karsiyaka
dc.contributor.authorKocakap, Derya Beyza Sayin
dc.contributor.authorOzkan, Serdar Yucel
dc.date.accessioned2020-06-25T18:13:28Z
dc.date.available2020-06-25T18:13:28Z
dc.date.issued2015
dc.departmentKırıkkale Üniversitesi
dc.description.abstractBackground: Periodontitis is triggered by periodontal pathogens and influenced by environmental and genetic factors. Genes encoding molecules related to the immune response are the main candidates for polymorphisms analysis and may be possibly associated with this pathology. Aim: The aim of the study was to evaluate the interleukin (IL)-17F Histidine161Arginine (H161R) and IL-23R Arginine381Glycine (R381Q) gene polymorphisms in patients with periodontitis in Turkish population. Materials and Methods: 90 periodontally healthy, 90 patients with chronic periodontitis and 57 patients with generalized aggressive periodontitis were included in the study. Participants were identified through clinical examinations and radiographs. DNA was isolated from venous blood samples from each patient and genotype analyses were made for single nucleotide polymorphisms (SNPs). Data were analyzed using the x(2) test. Results: The comparison of allelic, genotypic frequencies of the IL-17F (H161R) and IL-23R (R381Q) polymorphisms revealed no significant differences between the periodontally healthy individuals and patients with periodontal diseases. Conclusion: On the basis of the present findings, it can be suggested that IL-17F gene (H161R) and IL-23R gene (R381Q) polymorphisms are not associated with the susceptibility to periodontitis in Turkish population.en_US
dc.identifier.citationOlgun, Ebru & Hendek, Meltem & Sayin, Derya & Kocakap, Sayin & Ozkan, Yucel & Professor, Assistant. (2015). Interleukin (IL)-17F (H161R) and IL-23R (R381Q) Gene Polymorphisms in Turkish Population with Periodontitis. Journal of Research in Medical and Dental Science. 3(2), 104-108.en_US
dc.identifier.doi10.5455/jrmds.2015322
dc.identifier.endpage108en_US
dc.identifier.issn2347-2545
dc.identifier.issn2347-2367
dc.identifier.issue2en_US
dc.identifier.startpage104en_US
dc.identifier.urihttps://doi.org/10.5455/jrmds.2015322
dc.identifier.urihttps://hdl.handle.net/20.500.12587/6199
dc.identifier.volume3en_US
dc.identifier.wosWOS:000375075300002
dc.identifier.wosqualityN/A
dc.indekslendigikaynakWeb of Science
dc.language.isoen
dc.publisherAmber Publicationen_US
dc.relation.ispartofJournal Of Research In Medical And Dental Science
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectPeriodontitisen_US
dc.subjectcytokinesen_US
dc.subjectpolymorphismen_US
dc.subjectinterleukin-17Fen_US
dc.subjectinterleukin-23Ren_US
dc.titleInterleukin (IL)-17F (H161R) and IL-23R (R381Q) Gene Polymorphisms in Turkish Population with Periodontitisen_US
dc.typeArticle

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