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Öğe Comparison of the clinical, radiographic, and histological effects of titanium-prepared platelet rich fibrin to allograft materials in sinus-lifting procedures(Wiley, 2018) Olgun, Ebru; Ozkan, Serdar Y.; Atmaca, Hasan T.; Yalim, Mehmet; Hendek, Meltem KarsiyakaAim: In the present study, we evaluated the clinical, radiographic, and histological comparisons of completely autologous titanium-prepared platelet rich fibrin (T-PRF) or allograft in sinus-lifting procedures. Methods Eighteen posterior maxilla requiring sinus-lifting procedures using the balloon-lifting technique for implant placement were selected. Ten sinuses were randomly assigned to T-PRF as the test group and eight to allografts as the control group. After 4 and 6 months in the test and control groups, respectively, computed tomography was done, and bone samples were received during implant surgery. Three months after the second surgery, implant stability was measured. Results: Radiological results showed that the allograft group had better results (62% in volume, 53% in density, and 69% in height) than the T-PRF group. Histomorphometric results showed that newly-formed bone ratios were 17.28 +/- 2.53 and 16.58 +/- 1.05 in the allograft group and T-PRF groups, respectively. There was no significant difference between the test and control groups (P = .611) for implant stability values. Conclusions: The use of T-PRF alone in sinus-lifting operations has successful clinical and histomorphometric results. Bone formation in the T-PRF group was accelerated to 4 months compared to allografts according to the histological results.Öğe Effect of Initial Periodontal Therapy on Oxidative Stress Markers in Gingival Crevicular Fluid, Saliva, and Serum in Smokers and Non-Smokers With Chronic Periodontitis(Wiley, 2015) Hendek, Meltem Karsiyaka; Erdemir, Ebru Olgun; Kisa, Ucler; Ozcan, GonenBackground: The aim of this case-control study with an intervention arm is to determine the effect of initial periodontal treatment on oxidative stress biomarkers in smokers and non-smokers with chronic periodontitis (CP). Methods: The study included 47 patients with CP (24 smokers [S+ P+] and 23 non-smokers [S-P+]) and 46 periodontally healthy individuals (23 smokers [S+ P-] and 23 non-smokers [S-P-]) for a total of 93 participants. Gingival crevicular fluid (GCF), serum, and saliva samples were obtained and clinical periodontal measurements were recorded at baseline and at the first and third months after periodontal therapy. 8-hydroxydeoxyguanosine (OHdG) and 4-hydroxynonenal (HNE) and enzyme activity of glutathione peroxidase (GSH-Px) were analyzed with enzyme-linked immunosorbent assay. Results: The level of 8-OHdD in GCF was found to be significantly higher in both periodontitis groups compared with both periodontally healthy groups. 8-OHdG and GSH-Px in saliva in both periodontitis groups were significantly increased compared with the S-P-group. In the S+ P+ group, 4-HNE in GCF was found to be significantly higher than in periodontally healthy participants. After initial periodontal treatment, the levels of 8-OHdG in GCF and saliva were significantly decreased in both periodontitis groups. Conclusion: Initial periodontal therapy may be helpful for diminishing oxidative stress in periodontitis.Öğe Effect of Initial Periodontal Treatment on Cardiovascular Risk Markers in Patients with Severe Chronic Periodontitis(Galenos Yayincilik, 2019) Hendek, Meltem Karsiyaka; Olgun, Ebru; Kisa, UclerObjective: The aim of the study was to determine the influence of initial periodontal treatment in patients with severe chronic periodontitis on inflammatory markers related to risk for cardiovascular diseases. Materials and Methods: A total of 80 non-smokers with systemically healthy, including 40 patients (29 female, 11 male) with severe chronic periodontitis (test group) and 40 periodontally healthy participants (21 female, 19 male) (control group) were included into the present study. The probing depth, clinical attachment level, plaque index, gingival index and blood samples were collected at baseline and at the 3rd months after treatment and the serum levels of asymmetric dimethylarginine (ADMA), endothelial nitric oxide synthase (eNOS), homocysteine (Hcy), monocyte chemoattractant protein-1 (MCP-1) were determined with enzyme-linked immunosorbent assay. Results: At baseline, all clinical periodontal parameters were significantly higher in the chronic periodontitis group than in the periodontally healthy group (p<0.05). After the initial periodontal treatment, in the test group, all of the clinical periodontal parameters showed a significant decrease compared to the baseline values (p<0.05). At baseline, ADMA, Hcy and MCP-1 levels were significantly higher in the test group than in the control group (p<0.05), and after treatment ADMA and MCP-1 levels showed a significant decrease whereas eNOS level showed significant increase (p<0.05). Conclusion: It was observed that initial periodontal treatment in patients with severe chronic periodontitis has positive effects on cardiovascular risk markers.Öğe Effects of T-PRF and A-PRF on the Osteogenic Biomarkers in Intrabony Defects of Periodontitis Patients(Cumhuriyet University Faculty of Dentistry, 2023) Sume, S. Selva; Hendek, Meltem Karsiyaka; Kisa, Ucler; Olgun, EbruObjectives: Different derivatives of platelet-rich fibrin (PRF) have been developed but the efficacy of these derivatives in tissue healing and regeneration is still unclear. The aim of this study was to evaluate the effects of titanium-prepared PRF (T-PRF) and advanced PRF (A-PRF) on osteogenic biomarkers in gingival crevicular fluid (GCF) and clinical parameters. Materials and Methods: Seventeen systemically healthy participants with 30 bilateral intrabony defects were recruited. Following phase I periodontal therapy, intrabony defects were treated either with A-PRF+open flap debridement (OFD) or T-PRF+OFD. Plaque index (PI), gingival index (GI), pocket depth (PD), clinical attachment loss (CAL) was recorded at the baseline and 6th month after treatment. GCF samples were collected at the baseline and 3rd, 6th months after surgery. Nuclear factor receptor activator (RANK), receptor activator nuclear kappa-B ligand (RANKL), osteoprotegerin (OPG) and tumor necrosis factor alpha converting enzyme (TACE) in GCF samples were analyzed by human enzyme-linked immunosorbent assay (ELISA). Results: In both groups, statistically significant changes were observed in clinical parameters, however, there was no difference between the groups. In terms of osteogenic biomarkers in GCF, there were no statistically significant differences between and within the groups. Conclusions: Different derivatives of PRF can be used to enhance the clinical outcomes of intrabony defects in periodontitis. © (2023), (Cumhuriyet University Faculty of Dentistry). All Rights Reserved.Öğe Evaluation of FGF-23 and 25(OH)D-3 levels in peri-implant sulcus fluid in peri-implant health and diseases(Wiley, 2019) Acipinar, Sukran; Hendek, Meltem Karsiyaka; Olgun, Ebru; Kisa, UclerBackground There are limited studies to date investigating vitamin D and fibroblast growth factor (FGF)-23 in different peri-implant conditions. Purpose To evaluate the peri-implant sulcus fluid (PISF) FGF-23 and 25-hydroxy-vitamin D-3 (25(OH)D-3) levels in peri-implant health and diseases. Materials and Methods A total of 90 dental implant sites (peri-implant healthy group [n = 30], peri-implant mucositis group [n = 30], and peri-implantitis group [n = 30]) in 53 participants were included in the study. Probing depth (PD), clinical attachment level (CAL), suppuration (S), modified plaque index (mPI), gingival index (GI), modified sulcus bleeding index (mSBI), and keratinized mucosa width (KMW) were recorded as clinical parameters, and PISF samples were obtained. FGF-23 and 25(OH)D-3 levels were analyzed by enzyme-linked immunosorbent assay. Results There were no statistically significant differences in FGF-23 concentrations among the groups (P > .05). The 25(OH)D-3 concentration was significantly lower in peri-implantitis group compared with the other two groups (P < .05). The mean total amount of FGF-23 in the peri-implantitis group was significantly higher than the peri-implant healthy group whereas 25(OH)D-3 total amount was significantly lower in the peri-implantitis group than the peri-implant healthy group. The 25(OH)D-3 concentration was significantly negatively correlated with CAL, PD, mPI, S, GI, and mSBI and statistically significant relationship was found between FGF-23 total amount and these clinical parameters (P < .05). There was a negligible positive correlation between 25(OH)D-3 and FGF-23 concentrations (tau = 0.169; P = .018). Conclusion Within the limitations of this study, it can be concluded that FGF-23 and vitamin D seems to affect peri-implant bone health, and further studies are needed to explain the association between FGF-23 and 25(OH)D-3 in peri-implant conditions.Öğe Evaluation of Salivary Procalcitonin Levels in Different Periodontal Diseases(Amer Acad Periodontology, 2015) Hendek, Meltem Karsiyaka; Erdemir, Ebru Olgun; Kisa, UclerBackground: The present study aims to investigate the levels of salivary procalcitonin (ProCT) in patients with different periodontal diseases. Methods: Seventy-two non-smokers are included in this study: 21 individuals with chronic periodontitis (CP), 14 individuals with generalized aggressive periodontitis (GAgP), 18 individuals with gingivitis (G), and 19 periodontally healthy (H) participants. Clinical periodontal parameters, including probing depth (PD), clinical attachment level (CAL), plaque index, and gingival index (GI), were assessed in all participants. Saliva samples were collected and examined for evaluating ProCT levels. Results: It was found that the median (interquartile range) salivary ProCT level was lowest in the H group: 0.00 (0.09) ng/mL; followed by the G group: 0.09 (0.11) ng/mL; the CP group: 0.15 (0.29) ng/mL; and highest in the GAgP group 0.28 (0.68) ng/mL. These differences were statistically significant between the H group and the other groups (P <0.05). There were positive correlations between the mean salivary ProCT level and GI, CAL, and PD. Conclusion: According to the present results, ProCT might play a role during periodontal inflammation, and an elevated salivary ProCT level is suggested as a potential biomarker for periodontal diseases.Öğe Evaluation of the Quality of Peri-implantitis Videos on YouTube(Lippincott Williams & Wilkins, 2023) Baris, Kubilay; Hendek, Meltem Karsiyaka; Olgun, EbruAlthough many studies have evaluated the quality of YouTube videos related to dentistry, just one study has evaluated the quality of YouTube videos related to peri-implantitis. The aim of the cross-sectional study was to evaluate the quality of peri-implantitis-related YouTube videos. Two periodontists evaluated 47 videos that met the inclusion criteria, such as the country of upload, source of videos, number of views, likes and dislikes, viewing rate, interaction index, number of days since upload, duration of the video, usefulness score, global quality scale score, and comments. Peri-implantitis was evaluated using a 7-question system of the videos, 44.7% and 55.3% were uploaded by commercial companies and health care professionals, respectively. Although the usefulness score of the videos uploaded by health care professionals was statistically significantly higher (P=0.022), the number of views, numbers of likes and dislikes were similar between the groups (P>0.050). Although the usefulness score and global quality scale score of the perfect videos were statistically different between the groups (P<0.001; P<0.001, respectively), the number of views, numbers of likes, and dislikes were similar. A strong positive correlation was found between the number of views and the number of likes (P<0.001). A strong negative correlation was found between the interaction index and the number of days since upload (P<0.001). As a result, YouTube videos on peri-implantitis were limited in number and had poor quality. Thus, videos of perfect quality should be uploaded.Öğe Interleukin (IL)-17F (H161R) and IL-23R (R381Q) Gene Polymorphisms in Turkish Population with Periodontitis(Amber Publication, 2015) Erdemir, Ebru Olgun; Hendek, Meltem Karsiyaka; Kocakap, Derya Beyza Sayin; Ozkan, Serdar YucelBackground: Periodontitis is triggered by periodontal pathogens and influenced by environmental and genetic factors. Genes encoding molecules related to the immune response are the main candidates for polymorphisms analysis and may be possibly associated with this pathology. Aim: The aim of the study was to evaluate the interleukin (IL)-17F Histidine161Arginine (H161R) and IL-23R Arginine381Glycine (R381Q) gene polymorphisms in patients with periodontitis in Turkish population. Materials and Methods: 90 periodontally healthy, 90 patients with chronic periodontitis and 57 patients with generalized aggressive periodontitis were included in the study. Participants were identified through clinical examinations and radiographs. DNA was isolated from venous blood samples from each patient and genotype analyses were made for single nucleotide polymorphisms (SNPs). Data were analyzed using the x(2) test. Results: The comparison of allelic, genotypic frequencies of the IL-17F (H161R) and IL-23R (R381Q) polymorphisms revealed no significant differences between the periodontally healthy individuals and patients with periodontal diseases. Conclusion: On the basis of the present findings, it can be suggested that IL-17F gene (H161R) and IL-23R gene (R381Q) polymorphisms are not associated with the susceptibility to periodontitis in Turkish population.Öğe Is the Level of Nitric Oxide in the Dental Follicular Tissues of Impacted Third Molars With a History of Recurrent Pericoronitis a True Marker of Oxidative Stress?(W B Saunders Co-Elsevier Inc, 2017) Hendek, Meltem Karsiyaka; Senses, Fatma; Kisa, Ucler; Aksoy, Nurkan; Tekin, UmutPurpose: Nitric oxide (NO) is an indicator of oxidative stress in several tissues. Its role in dental follicular (DF) tissues of impacted third molars with a history of recurrent pericoronitis is not well elucidated. The present study compared NO levels between inflamed and noninflamed DF tissues of impacted third molars with a history of recurrent pericoronitis. Materials and Methods: A cross-sectional study was designed. The study sample included inflamed DF tissues (test group) with certain local inflammatory symptoms, such as pain, tenderness, swelling, and erythema and noninflamed DF tissues (control group) without local inflammatory symptoms of impacted mandibular third molars. Each patient contributed only 1 specimen to the samples. All tissues samples were biochemically investigated for NO levels as an indicator of oxidative stress. The primary predictor variable was inflammatory status; secondary predictor variables were age and gender. The primary outcome variable was NO level. Descriptive and comparative analyses were conducted. Results: The test group consisted of 57 patients (28 men, 29 women; mean age, 23.28 +/- 5.16 yr) and the control group consisted of 57 patients (30 men, 27 women; mean age, 23.02 +/- 5.42 yr). No relevant inter-group differences were noted for demographic findings such as age and gender. NO levels were significantly higher in inflamed DF tissues of impacted third molars than in noninflamed DF tissues (P < .05). Conclusion: Results of this study showed that NO might be used as an indicator of oxidative stress and the necessity to remove impacted mandibular third molars with a history of recurrent pericoronitis. (C) 2017 American Association of Oral and Maxillofacial Surgeons.Öğe Prophylactic and therapeutic effects of (6)-shogaol on alveolar bone loss in experimental periodontitis(Istanbul Univ Press, Istanbul Univ Rectorate, 2024) Bezirci, Didem; Hendek, Meltem Karsiyaka; Ozcan, Gonen; Kul, Oguz; Anteplioglu, Tugce; Olgun, EbruPurpose (6)-Shogaol is the most prevalent bioactive compound in ginger. The aim of this study was to examine both the prophylactic and therapeutic effects of (6)-shogaol in an experimental periodontitis model. Materials and Methods Thirty-five male Wistar albino rats were divided into four groups. In the healthy group (n=5), no intervention was undertaken. In the periodontitis group (n=10), periodontitis was induced by ligature placement for 14 days. In the prophylaxis group (n=10), periodontitis was induced with ligature placement for 14 days, and during this time, 20 mg/kg/day of (6)-shogaol was administered via oral gavage. In the therapeutic group (n=10), periodontitis was induced with ligature placement for 14 days, and following the removal of the ligature, 20 mg/kg/day of (6)-shogaol was administered via oral gavage for 14 days. Alveolar bone loss was histometrically measured, and malondialdehyde (MDA), superoxide dismutase (SOD), glutathione peroxidase (GP), nuclear factor kappa B (NF-kappa B), receptor activator of nuclear factor kappa B ligand (RANKL), and osteoprotegerin (OPG) were immunohistochemically analyzed. Results Alveolar bone loss was significantly lower in the healthy group than in the remaining groups, as well as in the therapeutic group than in the periodontitis group (p<0.001). RANKL/OPG was significantly higher in the periodontitis group compared to the remaining groups and in the prophylaxis group compared to the therapeutic group (p<0.001). MDA was significantly lower in the healthy group than in the remaining groups (p<0.001). SOD was significantly lower in the periodontitis group than in the prophylaxis and therapeutic groups (p=0.039 and p=0.042, respectively). GP was significantly lower in the healthy group than in the prophylaxis and therapeutic groups (p=0.031 and p=0.002, respectively). Conclusion The administration of (6)-shogaol modulated the RANKL/OPG balance and antioxidant status in rats with ligature-induced periodontitis.Öğe Salivary LL-37 and periodontal health in children exposed to passive smoking(Wiley, 2019) Hendek, Meltem Karsiyaka; Almaz, Merve Erkmen; Olgun, Ebru; Kisa, UclerBackground Antimicrobial peptides play an important role in the local defence of oral cavity. Cigarette smoke has detrimental effects on immune defence mechanisms. The effect of passive smoking on salivary LL-37, as an antimicrobial peptide, in children has not yet been reported. Aim The aims of this study were to evaluate salivary LL-37 levels in PS-exposed and PS-unexposed children and to investigate the association between salivary LL-37 levels and periodontal clinical parameters. Design Unstimulated salivary samples were collected from 180 children (90 PS-exposed [38 girls and 52 boys; mean age: 9.36 +/- 1.60 years] and 90 PS-unexposed [43 girls and 47 boys; mean age: 9.02 +/- 1.71 years]) in this study. Periodontal clinical parameters, including plaque index (PI), gingival index (GI), probing depth (PD), and clinical attachment level (CAL), were recorded in all children. Salivary cotinine and LL-37 levels were measured by enzyme-linked immunosorbent assay. Results PI and GI values in PS-exposed children were significantly higher than those in PS-unexposed children. The mean salivary cotinine concentration was significantly higher in PS-exposed children than in control subjects. The mean salivary LL-37 concentration of PS-exposed children was significantly lower (100.71 +/- 72.14 pg/mL) than that of PS-unexposed children (151.84 +/- 107.89 pg/mL). Conclusion Passive smoking could suppress salivary LL-37 concentrations in children.Öğe The effect of SARS-CoV-2 effective mouthwashes on the staining, translucency and surface roughness of a nanofill resin composite(Mosher & Linder, Inc, 2021) Bayraktar, Yusuf; Karaduman, Kubra; Ayhan, Baturalp; Hendek, Meltem KarsiyakaPurpose: To evaluate the effect of SARS CoV-2 effective mouthwashes on the color change (Delta E), translucency parameter (TP) and average surface roughness (Ra) of a nanofill resin composite (Filtek Ultimate). Methods: 91 composite specimens (10 mm in diameter, 1 mm thickness) were prepared using a stainless-steel mold and randomly divided to seven groups as follows: Group 1 (CHX): 0.12% CHX digluconate + 0.15% benzydamine hydrochloride (96% alcohol), Group 2 (HAc): hypochlorous acid (500 ppm), Group 3 (PVP-I): 1% povidone iodine, Group 4 (H2O2): 1.5% hydrogen peroxide, Group 5 (CHX + C): 0.09% chlorhexidine digluconate + cyclodextrin + citrox, Group 6 (CPC): 0.075% cetylpyridinium hydrochloride, Group 7 (Control): artificial saliva. The initial color values were determined by a spectrophotometer on both white and black backgrounds. The specimens were immersed in 20 mL mouthwash for 1 minute with a 12-hour interval. The Ra, AE and TP were determined after 1, 2 and 3 weeks. Data were analyzed using repeated measures ANOVA, one-way ANOVA, post-hoc Bonferroni and Tukey tests (P< 0.05). Results: The highest and the lowest AE3 (after 3 weeks) value were observed in H2O2 (1.57 +/- 0.29) and CHX (0.92 +/- 0.17) groups, respectively. The CHX and CPC groups demonstrated significantly lower AE3 values than the control group (P< 0.05). CHX, HAc and PVP-I significantly affected the TP (P< 0.05). None of the groups demonstrated any significant changes of Ra scores (P> 0.05).
