Yazar "Koçak, Mukadder" seçeneğine göre listele
Listeleniyor 1 - 17 / 17
Sayfa Başına Sonuç
Sıralama seçenekleri
Öğe Absence of estrogen and progesterone receptors around the affected vessels of angioma serpiginosum - Case report(Adis Int Ltd, 2006) Erkek, Emel; Bozdoğan, Önder; Akarsu, Cengiz; Atasoy, Pınar; Koçak, MukadderAngioma serpiginosum is a disorder of dilated superficial dermal capillaries. The disease is considered by some authors to be a consequence of increasing levels of estrogens. We present a case of angioma serpiginosum in a 46-year-old White woman. The lesions consisting of red-purple puncta were grouped as vaguely annular and angular patches with serpiginous borders, located on the right side of the neck, the right side of the abdomen, and on the left arm. Histopathologic examination revealed clusters of dilated capillaries in the dermal papillae, without endothelial proliferation. Periodic acid-Schiff (PAS) stain-positive deposits were noted around the affected blood vessels. However, immunohistochemical analysis revealed the absence of estrogen and progesterone receptors within the involved blood vessels. Hormonal assays were also normal. Our observations suggest that a hormonal stimulus probably plays no role in the pathogenesis of angioma serpiginosum. The significance of PAS-positive deposits as a diagnostic marker for angioma serpiginosum needs further confirmation.Öğe Absence of human papillomavirus antigens in cutaneous soft fibromas(2003) Koçak, Mukadder; Erkek, Emel; Bozdoğan, Önder; Birol, Ahu; Atasoy, PınarGiriş: Derinin yumuşak fibromlarının gerçek nedeni bilinmemekle birlikte deri yaşlanması, şişmanlık, diyabet, gebelik, menopoz, akromegali ve genetik yatkınlık ile ilişkili olabilecekleri ileri sürülmektedir. Son zamanlarda insan papilloma virüsleri de yumuşak fibrom oluşumunda potansiyel etyolojik faktör olarak suçlanmışlardır. Amaç: Bu çalışmada yumuşak fibrom etyopatogenezinde insan papilloma virüslerinin rolünün araştırılması amaçlanmış ve bu lezyonların diyabet ve obezite ile ilşkileri de sorgulanmıştır. Hastalar ve Yöntem: Bu amaçla 37 hastanın lezyonel deri örneklerinde immünhistokimyasal metod ile HPV antijenleri çalışılmıştır. Her hastadan açlık ve tokluk kan şekeri ve gayitada gizli kan tetkikleri rutin olarak istenmiştir.Bulgular: Lezyonel deri biyopsilerinden yalnızca birinde (2.7 %) HPV antijen varlığı saptanmıştır. On-üç hastanın (35.1 %) vücut kütle indeksi 30'un üstünde hesaplanmıştır. Açlık ve/ veya tokluk kan şekeri 14 hastada (37.8 %) yüksek bulunmuştur. Sonuç: Bu bulgular çok sayıda yumuşak fibrom ile başvuran hastalarda karbonhidrat metabolizmasının değerlendirilmesi gerektiğine işaret etmekte ve insan papilloma virüslerinin bu lezyonların etyolojisinde rolü olmadığını düşündürmektedir.Öğe Analysis of estrogen and progesterone receptors in lesional and normal skin of patients with acne rosacea(2003) Erkek, Emel; Bozdoğan, Önder; Koçak, Mukadder; Birol, Ahu; Atasoy, PınarGiriş: Rozase etyolojisinde hormonal faktörlerin rol oynayabileceğine ilişkin çok sayıda kanıt bulunmaktadır. Lezyonel deride östrojen reseptörlerinin azalması ve progesteron reseptörlerinin artışı hipotetik olarak rozase oluşumunda önemli olabilir. Amaç: Bu çalışmada rozaseli hastaların lezyonel ve normal deri dokularında östrojen ve progesteron reseptörlerinin ekspresyonunun saptanması amaçlanmıştır. Hastalar ve Yöntem: Bu amaçla rozaseli 20 hastanın lezyonel deri örneklerinde ve gönüllü 5 hastanın nonlezyonel deri örneklerinde immünhistokimyasal metod ile östrojen ve progesteron reseptörleri çalışılmıştır. Bulgular: Lezyonel deri biyopsilerinden 2'sinde (10%) progesteron reseptör varlığı saptanmış, ancak hiç bir örnekte östrojen reseptörleri gösterilememiştir. Sonuç: Bu bulgular rozase etyolojisinde östrojen ve progesteron reseptörlerinin önemi hipotezini desteklememekle birlikte bloklanamayan/ karşı konulamayan androjenik uyarı hipotezinin araştırılması gerektiğini düşündürmektedir.Öğe Assessment of ovarian stromal artery Doppler characteristics and serum hormone levels in patients with Behcet disease(Turkish Soc Radiology, 2010) Çil, Aylin Pelin; Karabulut, Ayşe Anıl; Koçak, MukadderPURPOSE The aim of the study was to examine serum hormone levels, ovarian volume, stromal artery Doppler parameters of patients with Behcet disease (BD) to assess whether there are vascular changes in the gonads of these patients. MATERIALS AND METHODS Twenty patients with BD and 31 healthy controls aged between 18-45 years were examined in the early follicular phase of the menstrual cycle (day 2-3) with transvaginal ultrasound to evaluate ovarian volume and ovarian stromal artery Doppler parameters. On the same day, blood was drawn for determining serum hormone levels. RESULTS Patients with BD and the controls were comparable with regard to age and body mass index at study inclusion. Although comparison of the ovarian stromal artery Doppler velocimetric parameters did not show significant differences, resistivity, pulsatility indexes and systolic/diastolic ratio were higher, while peak systolic and end diastolic velocities were lower, in BD patients compared to controls. The mean ovarian volume of patients with BD was smaller than the controls but this difference did not reach statistical significance. There were no statistically significant differences between serum hormone levels of either group. We did not find any correlations between hormone levels and mean ovarian stromal artery Doppler parameters of patients with BD. CONCLUSION Ovarian stromal artery Doppler parameters of patients with BD did not show any significant differences compared to healthy controls. Therefore, we conclude that ovarian stromal artery is not involved in patients with BD as assessed by transvaginal Doppler ultrasound and serum hormone levels do not differ from the levels of healthy controls.Öğe Behçet hastalığının aktivitesini daha pratik ve kolay yöntemlerle belirleyebilir miyiz?(2014) Özuğuz, Pınar; Kaçar, Seval Doğruk; Akçi, Önder; Balta, İlknur; Karaca, Şemsettin; Koçak, MukadderBehçet Hastalığı (BH), aktivitesini gösteren tek bir laboratuvar bulgusu olmayıp, farklı parametreler bazı çalışmalarda değerlendirilmiştir. Çalışmamızın amacı, inflamasyon belirteci olarak kullanılan, Nötrofil/lenfosit oranı (NLO), trombosit /lenfosit oranı (TLO) ve koagulasyona eğilimi gösteren MPV, MPV/trombosit oranlarını değerlendirmek, güncel, kolay, ucuz ve hızlı olabilecek aktivite belirtecini belirlemektir. Behçet Hastalığı Uluslararası Çalışma Grubu Tanı Kriterlerine göre BH tanılı 85 hasta ve yaş-cinsiyetle uyumlu sağlıklı 40 hasta çalışmaya dahil edildi. Hastalar aktivite kriterlerine göre değerlendirilerek aktif ve remisyon dönemi şeklinde 2 ye ayrıldı. Hastaların tam kan sayımı, Eritrosit Sedimantasyon hızı (ESR), C-Reaktif Protein (CRP) değerleri retrospektif olarak tarandı. 85 BH'nın 40'ı aktif dönemdeyken, 45 tanesi remisyondaydı. Hastaların hastalık süresi, %16,5'i 1 yıldan az, %50,6'sı 1-5yıl, %32,9'u 5 yıldan uzundu. Hasta ile kontrol grubu arasında MPV değerleri ve NLO arasında istatistiksel olarak anlamlı yükseklik saptanırken (p0.05), MPV/trombosit oranı ve PLO değerlerindeki fark istatistiksel olarak anlamlı değildi (p0.05). Hasta grubu kendi içinde aktif ve remisyon olarak değerlendirildiğinde ise ESR, CRP, NLO aktif dönemde belirgin olarak yüksekti (p0.05) . Hastalarımızdan derin ven trombozu hikayesi olan sadece 6 hasta vardı. Bu hastaların MPV ve MPV/trombosit oranları belirgin olarak daha yüksek olmakla birlikte, hasta sayısı az olduğu için yeterli istatistiksel değerlendirme yapılamadı. Sonuç olarak BH multisistemik vaskülitik bir süreci içerdiği için infamasyon belirteci olarak NLO belirgin olarak yüksek saptanmıştır. Hastalarda aktivite belirteci olarak ESR, CRP dışında NLO kullanılabilir. Hastalarda tromboza eğilimi gösteren MPV daha yüksek saptanmaktadır. MPV değerinin yüksek olduğu hastalarda antitrombotik tedaviye ihtiyaç duyulabilirÖğe Bilateral upper eyelid edema in Melkersson-Rosenthal syndrome(Lippincott Williams & Wilkins, 2005) Akarsu, Cengiz; Atasoy, Pınar; Erdoğan, Sibel; Koçak, MukadderMelkersson-Rosenthal syndrome is an uncommon disorder characterized by a triad of facial nerve palsy, orofacial edema, and fissured tongue. A 42-year-old woman with Melkersson-Rosenthal syndrome presented with painless, nonpitting, bilateral asymmetric upper eyelid edema. The left eyelid was a bit larger than the right eyelid. CT and MRI demonstrated periorbital soft tissue thickening compatible with the microscopic findings of infiltration of lymphocytes, edema, and cystic dilatation of lymphatic vessels. After treatment by systemic doxycycline and corticosteroid, she showed some improvement of the eyelid edema. Isolated bilateral eyelids swelling may be observed in Melkersson-Rosenthal syndrome. In the case of unexplained nonpitting eyelid edema, biopsy should be performed.Öğe The Effect of Behcet's Disease on Sexual Function and Psychiatric Status of Premenopausal Women(Elsevier Sci Ltd, 2009) Koçak, Mukadder; Basar, M. Murad; Vahapoğlu, Güler; Mert, H. Çağatay; Güngör, ŞuleLittle is known about the relationship between Behcet's disease (BD) and female sexual dysfunction (FSD). The aims were to evaluate the prevalence of FSD in premenopausal BD patients and to compare hormonal and psychiatric conditions to healthy subjects. A total of 71 married women with BD and 63 healthy married women between 18 and 44 years old were enrolled into the study. After evaluating detailed history and physical examination, serum steroid hormone levels were measured. Presence of genital ulcerations in physical examination and any medical treatment were recorded in patients. All subjects were asked to complete the Female Sexual Function Index (FSFI) for sexual status and Beck Depression Inventory (BDI) for psychiatric assessment. FSFI and BDI scores and serum sex steroid hormone levels were measured in women with BD and healthy controls. The mean BDI score of patients was significantly greater than that for controls (P = 0.001), and there was a statistically significant difference between BDI scores (Pearson chi(2) = 19.109, P = 0.001). FSD was found in 34 patients with BD (47.9%) and in 11 controls (17.5%). A statistically significant difference was found between the two groups (Pearson chi(2) = 13.855, P = 0.001). While the most common sexual problem in the patients with BD was diminished arousal (n = 49, 69.0%), diminished desire was found in 32 patients (45.1%) and lubrication problems in 36 patients (50.7%). There was a statistically significant negative correlation between BDI and FSFI score in BD patients. On the contrary, there was no relationship between FSFI and presence of genital ulcerations. FSD is more common in BD patients than in healthy subjects. We conclude that depressive mood according to the BDI scale correlates with the sexual status of BD patients, and this may be because of the depressive effect of BD as a chronic disease. Kocak M, Basar MM, Vahapoglu G, Mert HC, and GungorS. The effect of Behcet's disease on sexual function and psychiatric status of premenopausal women. J Sex Med 2009;6:1341-1348.Öğe The Efficacy of Intermittant Low-Dose Systemic Corticosteroid in the Treatment of Alopecia Areata(2004) Birol, Ahu; Erkek, Emel; Tuncez, Fatma; Saylam Kurtipek, Gülcan; Bağcı, Yeter; Koçak, MukadderAlopecia areata (AA) is a common cause of non-scarring alopecia characterized by patchy hair loss. AA is difficult to treat because of its chronic and inflammatory nature. The aim of the present study was to investigate the effect of low-dose systemic corticosteroids in the treatment of AA. Fifteen patients with AA were included in this study. Systemic prednisolone 10-15 mg/day on 2 consecutive days per week for 6 months was administered. Fourteen patients (93.3%) had patchy alopecia areata. One patient (6.3%) had alopecia universalis. Seven (46.7%) patients showed complete healing, 5 (33.3%) showed partial response and 3 (20%) did not respond to treatment. Low-dose intermittant corticosteroid therapy may be a successful and well tolerated treatment option in AA and also in patients with alopecia totalis and universalis.Öğe The efficacy of intermittant low-dose systemic corticosteroid in the treatment of alopecia areata(2004) Birol, Ahu; Erkek, Emel; Tunçez, Fatma; Kurtipek, Sayam Gülcan; Bağcı, Yeter; Koçak, MukadderAlopecia areata (AA) is a common cause of non-scarring alopecia characterized by patchy hair loss. AA is difficult to treat because of its chronic and inflammatory nature. The aim of the present study was to investigate the effect of low-dose systemic corticosteroids in the treatment of AA. Fifteen patients with AA were included in this study. Systemic prednisolone 10-15 mg/day on 2 consecutive days per week for 6 months was administered. Fourteen patients (93.3%) had patchy alopecia areata. One patient (6.3%) had alopecia universalis. Seven (46.7%) patients showed complete healing, 5 (33.3%) showed partial response and 3 (20%) did not respond to treatment. Low-dose intermittant corticosteroid therapy may be a successful and well tolerated treatment option in AA and also in patients with alopecia totalis and universalis.Öğe The efficacy of intermittant low-dose systemic corticosteroid therapy in vitiligo(2004) Erkek, Emel; Birol, Ahu; Kurtipek, Saylam Gülcan; Tunçez, Fatma; Bağcı, Yeter; Koçak, MukadderAmaç: Vitiligo depigmente lezyonlar ile karakterize, akkiz, otoimmun bir hastalıktır. Çalısmanın amacı düşük doz, sistemik kortikosteroid tedavisinin vitiligo tedavisindeki rolünü araştırmaktır.Gereç ve Yöntemler: Calışmamıza 16 hasta dahil edilmiştir. Sistemik prednizolon 10-15 mg/gün, haftanın 2 ardışık günü, 6 ay süre ile uygulanmıştır.Bulgular: 14 hastada non-segmental [10 (62.5%) simetrik jeneralize- 4 (25%) akrofasyal) ve 2 (12.5%)] hastada segmental vitiligo tespit edildi. Altı aylık tedavi sonrasinda 6 (37.5%) hastada foliküler repigmentasyon, tespit edilirken 10 (62.5%) hastada tedaviye yanıt alınamadı. Hastaların hiçbirinde tam düzelme tespit edilmedi.Sonuç: İntermitan, düşük doz sistemik kortikosteroid vitiligo tedavisinde etkili bulunmamıştır.Öğe Executive dysfunctions and depression in Behcet's disease without explicit neurological involvement(Wiley, 2006) Erberk-Özen, Nurper; Birol, Ahu; Boratav, Cumhur; Koçak, MukadderThis study aims to assess the executive functions and depression status in patients with Behcet's disease without explicit neurological involvement and to evaluate cognitive functions in this group of patients independent of accompanying depression. In the present study, 30 patients with Behcet's disease in the non-active phase of their illness and 30 healthy volunteers were included. In the evaluation of depression levels, Beck Depression Inventory was employed. The executive functions of the patients were evaluated by Wisconsin Card Sorting Test (WCST) and Stroop Test (ST). Beck Depression Inventory scores measured in the Behcet's disease group, in which no clinically serious depression was observed, were higher than the control group. Then, it was observed that the scores of neuropsychological tests of the Behcet's disease group were found to be significantly lower, especially in WCST, while significant relations were revealed between Beck Depression Inventory scores and WCST, ST scores. The authors' findings suggest that there may be factors other than depression causing executive impairment in patients with Behcet's disease without explicit neurological symptoms. Executive dysfunctions may occur in association with mild depressive states due to chronic disease stress or silent and/or future neurological involvement of Behcet's disease, especially in the frontal lobes.Öğe Fox-Fordyce hastalığı(2002) Erkek, Emel; Koçak, Mukadder; Atasoy, Pınar; Birol, Ahu; Bozdoğan, ÖnderFox-Fordyce hastalığı nadir görülen, sporadik, apokrin ter bezi retansiyonu sonucu oluşan, kaşıntılı, foliküler papüllerle karakterize bir dermatozdur. Patogenezindeki en önemli basamak apokrin ter bezi duktuslarının tıkanması ve rüptürüdür. Bu makalede, Fox-Fordyce tanısı alan bir olgu sunulmuş ve literatür ışığında klinikopatolojik özellikleri tartışılmıştır.Öğe Giant eyelid molluscum contagiosum presenting as preseptal cellulitis(Wiley-Blackwell, 2014) Örnek, Kemal; Onaran, Zafer; Koçak, Mukadder…Öğe Nörolojik tutulumu olmayan Behçet hastalarında bilişsel bozukluklar(2004) Özen, Erberk Nurper; Birol, Ahu; Boratav, Cumhur; Koçak, MukadderAmaç: Behçet Hastalığı (BH) kronik seyirli, nörolojik tutulum yapabilen, etiyolojisi belirsiz bir hastalıktır. Nörolojik tutulum olan BH, nöro-Behçet hastalığı (NBH) olarak bilinir. Yazında BH ile ilgili nöro-psikiyatrik çalışmalar çoğunlukla NBH olan grupta yapılmıştır. Pek çok psikiyatrik ve nörolojik hastalıkta olduğu kadar, tıbbi hastalıklarda da bilişsel işlevlerin bozulduğu bilinir. Kronik hastalıklarda bilişsel işlev bozukluğu, hastalığa eşlik eden depresyona bağlı ya da ondan bağımsız olarak görülebilir. Bu çalışmanın amacı, nörolojik tutulumu olmayan BH hastalarının depresyon düzeyi ve bilişsel işlevlerinin değerlendirilmesidir. Yöntem: BH tanısı ile dermatoloji kliniği tarafından izlenen, hastalıkları açısından aktif dönemde olmayan 30 hasta ile 30 sağlıklı gönüllü çalışmaya alındı. Hastalar International Study Group (ISG) BH tanı kriterlerini karşılıyordu ve aynı kriterlere göre hiç birinde NBH yoktu. Hastaların bilişsel işlevleri Wisconsin Kart Eşleme Testi (WKET) (Wisconsin Card Sorting Test -WCST) ve Stroop Testi-TBAG Formu (ST-TBAG) ile, depresyon düzeyleri Beck Depresyon Ölçeği (BDÖ) (Beck Depression Inventory -BDI) ile değerlendirildi. Bulgular: BH grubunun test performansları daha bozuktu; yaş, cinsiyet, eğitim düzeyleri bazı test skorlarına etkiliydi, ancak BDÖ skoru ile testler arasında anlamlı ilişki saptanamadı. Sonuç: Test skorlarından elde edilen veriler, nörolojik tutulumu olmayan BH'de bilişsel işlev bozukluğuna yol açan depresyon dışında etkenler olabileceğini düşündürüyor.Öğe PCR analysis of HSV-negative erythema multiforme for the expression of other herpesviruses(2003) Koçak, Mukadder; Erkek, Emel; Kısa, Özgül; Güney, Çakır; Birol, AhuBackground: Herpes simplex virus (HSV) is the primary herpesvirus implicated to have a causal role in erythema multiforme (EM), both in cases with an antecedent herpetic infection and in idiopathic EM. However, the association of EM with several other viral infections has been clearly documented. Objective: The aim of the present study was to investigate a hypothetical role for the remaining members of the herpesvirus family in HSV-negative cases of EM. Methods: Fresh, unfixed lesional skin biopsies from 25 patients with HSV-negative EM were studied for the presence of Epstein-Barr virus(EBV), cytomegalovirus (CMV), human herpesvirus-6 (HHV-6) and human herpesvirus-7 (HHV-7) by using polymerase chain reaction (PCR) and nested PCR. Results: PCR revealed the absence of specific DNA sequences for EBV, CMV, HHV-6 and HHV-7 in all lesional EM specimens analyzed. Conclusion: These findings do not support an etiological role for non-HSV members of the herpesvirus family in HSV-negative EM.Öğe Retinal nerve fiber layer thickness in vitiligo patients(Medknow Publications & Media Pvt Ltd, 2013) Örnek, Nurgül; Onaran, Zafer; Koçak, Mukadder; Örnek, KemalBackground: This study was designed to investigate the effect of vitiligo on the retinal nerve fiber layer (RNFL) thickness. Materials and Methods: This prospective study was conducted in the Department of Ophthalmology at Kirikkale University during 2010 and 2011. Sixty eight eyes of 34 vitiligo patients were included in the study. Eighty four eyes were served as control. RNFL thickness was measured by scanning laser polarimetry (Nerve Fiber Analyzer, GDx VCC: 5.3.3; Laser Diagnostic Technologies, San Diego, CA, USA). Results: The mean duration of vitiligo was found to be 9.8 +/- 2.3 years. The mean average RNFL thickness outside the disc margin was significantly lower in the right eyes of vitiligo group in comparison to the controls (P = 0.02). The mean average thickness of RNFL beneath the measuring ellipse in the superior sector of both eyes were significantly lower than the controls (P = 0.004, P = 0.008, respectively). The topographical distributions of RNFL thickness in superior, inferior, nasal and temporal quadrants were similar for two groups. Conclusion: RNFL thickness seems to be unaffected in vitiligo patients.Öğe Topical ophthalmic cyclosporine in the treatment of toxic epidermal necrolysis(Hindawi Limited, 2011) Onaran, Zafer; Usta, Gülşah; Koçak, Mukadder; Örnek, Kemal; Büyükkoçak, ÜnaseAim. To describe a case of toxic epidermal necrolysis (TEN) with ocular involvement treated with topical ophthalmic cyclosporine. Case Presentation. A 20-year-old woman developed TEN following administration of carbamazepine that was prescribed for epilepsy. Ophthalmic examination revealed bilateral pseudomembranous conjunctivitis. She was hospitalized in the intensive care unit and treated with intravenous corticosteroid and immunoglobulin. Topical cyclosporine was used in combination with topical corticosteroids for ocular surface disease. Following two months of ocular treatment, she recovered without any severe ocular complication. Ocular examination at the four-month followup showed a 2mm of symblepharon in the lower fornix as the sole pathologic finding. Conclusion. Topical ophthalmic cyclosporine may contribute to decrease the ophthalmic complications of TEN and should be considered in the acute stage of the disease. © 2011 Zafer Onaran et al.
