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    Gastric Helicobacter-like Organisms in Stray Cats: Identification, Prevalence, and Pathologic Association
    (Univ Agriculture, Fac Veterinary Science, 2016) Dag, Serpil; Sozmen, Mahmut; Cihan, Mete; Tunca, Recai; Kurt, Basak; Devrim, Alparslan Kadir; Ozen, Hasan
    Total of 30 domestic stray cats (Felis cattus) were investigated for the presence of different species of gastric Helicobacter-like organisms (GHLO) by immunohistochemistry and polymerase chain reaction (PCR) analysis. The severity and distribution of pathologic changes in different regions of stomach were assessed microscopically. GHLO were present in all areas of the stomach in 93.3% cats investigated. Morphologically two different types of spiral bacteria were recognized. In 53.3% cats H. felis like organisms and in 76.7% cats H. heilmannii like organisms were determined. Mixed presence of both bacteria was seen in 43.3% cases. H. pylori was not detected in any of the cats. Mild to severe gastritis were observed in 90.0% cats. GHLO were present in fundus, corpus and pyloric antrum regions in similar densities. The most striking histopathological changes were lymphocyte and neutrophil infiltrations, fibrosis in the lamina propria, and lymphoid follicle formation. There was no significant relationship between the degree of bacterial density and the extent of histopathological changes. GHLOs were present on the mucosal surface, in the lumen of gastric glands, and in the cytoplasm of parietal cells. In conclusion, PCR and immunohistochemistry can be successfully used in detection of GHLOs. The results of the study show also that H. heilmannii and H. felis are frequent agents in stray cats, and hence suggest that these animals might be common reservoirs for these microorganisms. However, the bacteria do not seem to be solely responsible for gastritis observed in some stray cats. (C) 2015 PVJ. All rights reserved
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    Osteoclast-like giant cell tumour arising from the kidney in a dog
    (Akademiai Kiado, 2005) Haziroğlu, Rıfkı; Kul, Oğuz; Tunca, Recai; Güvenç, Tolga
    In this study, a case of osteoclast-like giant cell turnout arising from the kidney is reported in an eight-year-old female Anatolian Shepherd dog. Macroscopically, the tumorous mass covered the hilus of the left kidney. It was 26 x 22 x 12 cm in size and 3700 g in weight. Metastatic tumorous nodules, 0.5-2.0 cm in diameter, were found on the abdominal side of the diaphragm and in the lungs. Microscopically, numerous large osteoclast-like multinucleated giant cells and spindle-spheroidal-shaped cells were seen. Osteoblastic differentiation and osteoid matrix were noted in a few areas at the periphery of the tumour, near the connective tissue septa. The stroma of the tumour tissue was vascular, oedematous and loose. By immunoperoxidase staining, tumour cells showed immunoreactivity for vimentin but not for keratin and desmin, indicating that the tumour had mesenchymal origin. This is the first report in the literature on a malignant osteoclast-like giant cell turnout arising from a visceral organ in animals.
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    An outbreak of avian tuberculosis in peafowl (Pavo cristatus) and pheasants (Phasianus colchicus) in a zoological aviary in Turkey
    (Czech Academy Agricultural Sciences, 2005) Kul, Oğuz; Tunca, Recai; Hazıroğlu, Rıfkı; Diker, K. Serdar; Karahan, Siyami
    Avian tuberculosis was diagnosed histopathologically and microbiologically in two pheasants (Phasianus colchicus) and two peafowl (Pavo cristatus) kept in the same aviary. The incidence of avian tuberculosis in the aviary was 6%. Non-mineralized caseogranulomas were present in the liver (3 cases), spleen (3 cases), intestine (2 cases), lung (2 cases), and cloaca (1 case). Granulomas in the lung were present only in peafowl. The presence of granulomas in the lung of both infected peafowl suggests that peafowl were exposed to the agent via the respiratory route rather than the alimentary route. Histopathologic findings were typical of avian tuberculosis, including acid fast bacilli and centrally located caseo-necrosis surrounded by epitheloid macrophages, lymphocytes, and multinucleated giant cells. Mycobacterium avium subsp. avium was isolated from tissue samples of all infected birds.
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    Protective effects of silymarin on fumonisin B-1-induced hepatotoxicity in mice
    (Korean Soc Veterinary Science, 2014) Sozmen, Mahmut; Devrim, Alparslan Kadir; Tunca, Recai; Bayezit, Murat; Dag, Serpil; Essiz, Dinc
    The present study was conducted to investigate the effect of silymarin on experimental liver toxication induced by Fumonisin B-1 (FB1) in BALB/c mice. The mice were divided into six groups (n = 15). Group 1 served as the control. Group 2 was the silymarin control (100 mg/kg by gavage). Groups 3 and 4 were treated with FB1 (Group 3, 1.5 mg/kg FB1, intraperitoneally; and Group 4, 4.5 mg/kg FB1). Group 5 received FB1 (1.5 mg/kg) and silymarin (100 mg/kg), and Group 6 was given a higher dose of FB1 (4.5 mg/kg FB1) with silymarin (100 mg/kg). Silymarin treatment significantly decreased (p < 0.0001) the apoptotic rate. FB1 administration significantly increased (p < 0.0001) proliferating cell nuclear antigen and Ki-67 expression. Furthermore, FB1 elevated the levels of caspase-8 and tumor necrosis factor-alpha mediators while silymarin significantly reduced (p < 0.0001) the expression of these factors. Vascular endothelial growth factor (VEGF) and fibroblast growth factor-2 (FGF-2) expressions were significantly elevated in Group 4 (p < 0.0001). Silymarin administration alleviated increased VEGF and FGF-2 expression levels (p < 0.0001). In conclusion, silymarin ameliorated toxic liver damage caused by FB1 in BALB/c mice.