Osteoclast-like giant cell tumour arising from the kidney in a dog
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Date
2005
Journal Title
Journal ISSN
Volume Title
Publisher
Akademiai Kiado
Access Rights
info:eu-repo/semantics/closedAccess
Abstract
In this study, a case of osteoclast-like giant cell turnout arising from the kidney is reported in an eight-year-old female Anatolian Shepherd dog. Macroscopically, the tumorous mass covered the hilus of the left kidney. It was 26 x 22 x 12 cm in size and 3700 g in weight. Metastatic tumorous nodules, 0.5-2.0 cm in diameter, were found on the abdominal side of the diaphragm and in the lungs. Microscopically, numerous large osteoclast-like multinucleated giant cells and spindle-spheroidal-shaped cells were seen. Osteoblastic differentiation and osteoid matrix were noted in a few areas at the periphery of the tumour, near the connective tissue septa. The stroma of the tumour tissue was vascular, oedematous and loose. By immunoperoxidase staining, tumour cells showed immunoreactivity for vimentin but not for keratin and desmin, indicating that the tumour had mesenchymal origin. This is the first report in the literature on a malignant osteoclast-like giant cell turnout arising from a visceral organ in animals.
Description
Guvenc, Tolga/0000-0003-1468-3415
Keywords
dog, giant cell, kidney, osteoclast-like, tumour
Journal or Series
Acta Veterinaria Hungarica
WoS Q Value
Q3
Scopus Q Value
Q2
Volume
53
Issue
2
Citation
closedAccess
