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Öğe The resistance of Gram-negative rods against isepamicin and other aminoglycosides(Aves, 2005) Kaygusuz, Sedat; Ayaşlıoğlu, Ergin; Özlük, Özlem; Kılıç, DilekThis study was conducted to investigate the resistance of Gram-negative rods against isepamicin and other aminoglycosides. Resistance against five different aminoglycosides were tested in 861 Gram-negative microorganisms which were isolated in nosocomial infections, including 546 Escherichia coli, 116 Proteus spp., 87 Klebsiella spp., 56 Enterobacter spp. and 56 nonfermentative bacteria. The microorganisms from various infection sites tested by using the disk diffusion method according to NCCLS recommendations. The resistance rates of all Gram-negative bacteria included in the study were 0.8% for isepamicin, 2.0% for amikacin, 2.1% for netilmicin, 5.9% for gentamicin and 7.9% for tobramycin. We conclude that isepamicin is the aminoglycoside with highest activity, and tobramycin with highest resistance rate. The resistance of aminoglycoside should be controlled and the use of rational antibiotic should be taken into condideration in nosocomial infections.Öğe Sustained Virologic Response with Triple Therapy in a Hemodialysis Patient with Chronic HCV Infection(Galenos Yayincilik, 2014) Kaygusuz, Sedat; Gül, Serdar; Gülhan, MuhammetChronic hepatitis C virus (HCV) infection is more prevalent and has been proven to be an independent risk factor over mortality among hemodialysis patients than normal population. Since sustained virologic response (SVR) is so beneficial and may be maintained in 90-100% of post-transplant cases, treatment of chronic HCV infection is strongly suggested for all patients undergoing renal transplantation. A 45-year-old male patient had been offered to have renal transplantation due to chronic renal failure, and referred to our clinic because of chronic HCV infection (HCV-RNA positive). He had received hemodialysis three times a week since 2007. The patient was diagnosed with chronic HCV infection fifteen years ago and was given a 48-week lasting IFN therapy in 2000 and a subsequent therapy of PEG-IFN-alpha 2a for 48 weeks in 2004. Although both therapies had yielded end of treatment responses, subsequent relapses occurred. The patient was given a combination treatment involving PEG-IFN-alpha 2a (135 mu g/wk) for 24 weeks and ribavirin (200 mg/day) for 24 weeks and telaprevir (3 x 750 mg) for the first 12 weeks, and a weekly control visit in our clinic. The therapy was generally well tolerated and SVR was achieved. Triple therapy might be used as a treatment option in hemodialysis patients with genotype 1 chronic HCV infections.Öğe Serum soluble CD30 levels in Behcet's disease(Clinical & Exper Rheumatology, 2004) Düzgün, Nursen; Ayaşlıoğlu, Ergin; Tutkak, HüseyinBehcet's disease is associated with the inflammatory response. Several reports indicate the presence of primarily CD4+ T cells of the Th1 subtype in the inflammation process of the disease. Serum soluble CD30 (sCD30) is reported to be released from CD4+ Th2 type cells and has been suggested to be a marker of Th2 activity In this study, serum sCD30 levels were measured in active and inactive patients with Behcet's disease, healthy controls and a group of patients with rheumatoid arthritis, typical Th1 disorder using enzyme immunoassay kit. Mean sCD30 value of 54 active patients were found significantly higher than in those of 17 inactive patients (p = 0.027), 20 healthy controls (p = 0.040) and 25 patients with rheumatoid arthritis (p < 0.001). There was a significant correlation between increased sCD30 levels and clinical activity index in active patients with Behcet's disease. High serum levels of sCD30 may reflect the activation of CD4+ T cells or a subset of them in active BD patients. In addition. to serum sCD30 levels, measurements of the Th2 cytokines may be a helpful tool for the evaluation of Th2 activity in Behcet's disease.Öğe Role of Microplastics in Chronic Rhinosinusitis Without Nasal Polyps(Wiley, 2024) Taş, Burak Mustafa; Tuna, Ayşegül; Kankılıç, Gökben Başaran; Koçak, Furkan Melih; Sencan, Ziya; Cömert, Ela; Bayar Muluk, NurayObjective: We aimed to examine the relationship between chronic rhinosinusitis without nasal polyps and microplastics. Methods: A total of 80 patients participated in this prospectively planned study. The patients were divided into two groups. Group 1 had 50 patients with chronic rhinosinusitis without nasal polyps, whereas Group 2 had 30 healthy volunteers. The age and gender of the participants were noted. Nose Obstruction Symptom Evaluation questionnaire was applied to the patients. The patients performed nasal lavage with saline. Microplastics were examined in the collected nasal lavage fluids, and their numbers were noted. The groups were compared on these values. Results: The mean age was 38.06 +/- 14.15 years in the chronic rhinosinusitis group without nasal polyps and 33.60 +/- 11.68 years in the control group. There was no significant difference between the groups in terms of age and gender. There was a significant difference in the number of microplastics between the chronic rhinosinusitis group without nasal polyps and the control group (p < 0.001). Microplastics were detected in all participants. Conclusions: We found more microplastics in patients with chronic rhinosinusitis without nasal polyps. According to this result, we can say that there may be a relationship between chronic rhinosinusitis and microplastics.Öğe Patient Satisfaction 18 months After a Two-day Quadruple Therapy for Helicobacter Pylori(Medi+World Int, 2005) Aydın, Serpil; Köseoğlu, Tankut; Ağalar, CananObjectives: Because the Helicobacter pylori (Hp) infection has been the most seen infection in the world, many research studies have been conducted to find an effective therapy regimen for eradication. Long-term regimens are being replaced by short term regimens as the long-term therapies cause more side effects and patient adjustment is not easy. Our aim was to determine the efficacy of a short-term therapy regimen and patient satisfaction by conducting a telephone survey 18 months after completion of the therapy regimen. Materials and Methods: The patients with upper gastrointestinal system complaints who had presented to the gastroenterology day clinic in Ankara Numune Hospital were chosen for this study. They were evaluated, taking into account their historical, physical, laboratory, endoscopic, and histopathological findings. Patients who were found with Helicobacter pylori, but had no other symptoms or disorders, were given a two-day amoxicillin, ornidazole, and tribismuthsubcitrate therapy after a five-day lansoprazole therapy. The evaluation was repeated one month after the regimen. In addition, a telephone survey was conducted 18 months after eradication, and the patients whose upper gastrointestinal system complaints were completely eradicated were asked if they had any additional upper gastrointestinal system complaints during this 18-month interval. Results: We applied the eradication therapy to 36 people. Complete eradication was obtained in 31 of the 36 patients. For the follow up telephone survey, we could not reach five of the patients due to changes in their address and/or telephone numbers; 15 patients indicated that they had not taken any drug; and 12 patients had no complaints during this 18-month period. Six patients received H2 receptor blocker irregularly, and five patients had taken our regimen once again on their own. All of the patients reached during the 18-month follow-up stated that they were satisfied with the therapy. Conclusion: Our regimen appears to relieve symptoms for a long time and it is considered to be effective from our patients' viewpoints.Öğe Nigella sativa seed-mediated green biosynthesis of silver nanoparticles and antimicrobial activity(Soc Mexicana Fisica, 2024) Böke, E.; Saygı, Kadriye Özlem; Erenler, R.; Kacmaz, B.; Ergene, AysunThis work introduces a systematic and efficient approach for producing stable AgNPs utilizngNigella sativa (Ns) seed aqua extract (AE), which exhibit strong antibacterial properties. The characterization of Ns-AgNPs was performed using a UV-visible spectrophotometer electronic microscopy (TEM), and energy-dispersive X-ray spectroscopy (EDX). The Ns-AgNPs did not show aggregation, as shown by the results of STEM and XRD. According to the EDX analysis in this research, it was determined that Ns-AgNPs, gave signals in the silver region (similar to 3 KeV) at 92.3%. Dynamic light scattering (DLS) was used to determine the average particle size and distribution profile of NsAgNPs. Ns-AgNPs showed significant antibacterial performance againstStaphylococcus aureousand Escherichia coli, being effective at low concentrations. Ns-AgNPs may be incorporated into wound dressings, surgical instruments, and medical devices to prevent infections and promote healing.Öğe Microplastics in different nasal irrigation options(Springer, 2024) Tuna, Ayşegül; Taş, Burak M.PurposeWe aimed to assess the presence of microplastics in nasal irrigation methods commonly used in the treatment of sinusitis and rhinitis, and to evaluate human exposure.MethodsA total of 150 samples were included in the study, consisting of nasal wash bottles containing nasal irrigation solution, seawater spray, syringes for nasal irrigation with isotonic solution. The amount of microplastics per millilitre in the samples and patient exposure during single use were assessed separately for each method and product. All samples were filtered using a stainless steel vacuum filter on filter paper with a pore size of 1.2 mu m, washed at least three times with distilled water and incubated at 45 degrees C for 24 h to prevent mould growth. Identification and counting of microplastics was performed using a Leica Flexacam C1 camera connected to an M80 stereomicroscope. The presence of microplastics was confirmed by the hot needle method and Nile red staining.ResultsAn average of 6.49 +/- 13.08 microplastics/product was detected in all filtered samples. The lowest microplastic count was 0 microplastics/product in syringes and the highest was 92 microplastics/product in nasal wash bottles. Significant differences in the amount of microplastics individuals were exposed to during a single use were found between nasal wash bottles and seawater brands, while no significant differences were found between syringe brands. When nasal wash kits, seawater sprays and isotonic nasal rinses were evaluated separately, significant differences were found in the number of microplastics, the microplastics/ml ratio and the number of microplastics exposed during a single use. The highest microplastic exposure was found in nasal irrigation bottles.ConclusionThe exposure of individuals to microplastics increases with medical support treatments, regardless of intranasal or intravenous administration. Due to the inflammation, oxidative stress and proliferation caused by microplastics, new regulations and inspections of production conditions should be implemented worldwide to reduce exposure.Öğe Biosynthesized silver nanoparticles and essential oil from Coriandrum sativum seeds and their antimicrobial activities(Virtual Co Physics Srl, 2021) Saygı, Kadriye Özlem; Kaçmaz, Birgül; Gül, S.Bacterial infections are one of the most serious health problems all over the world, which cause need for the discovery of new drug. Since antibiotic resistance is a major threat to both humans and the environment, there is a need for studies on the antimicrobial properties of different forms of traditionally used plants. The seeds of Coriandrum sativum were used to isolate essential oil (EO) and to synthesize silver nanoparticles (C-AgNPs). The synthesized AgNPs were characterized by UV-Visible spectrophotometry, Scanning Electron Microscopy (SEM), Energy Dispersive X-ray (EDX), X-ray difraction (XRD) and Fourier Tranmission Infrared (FTIR). The major oil constituents were characterized by GC-MS as Linalool (79.12%), Camphor (6.16%), gamma-Terpinene (2.82%) and alpha-Pinene (2.67%). The surface plasmon resonance (SPR) of C-AgNPs at 437 nm was recorded on the UV-Vis spectrometer. The spherical and homogenous of C-AgNPs was presented in SEM images. EDX showed elemental distribution and confirmed C-AgNPs. A characteristic intense peak was at 3.0 keV. The antibacterial activities of the essential oil and AgNPs form of Coriandrum sativum seed against Staphylococcus aureus ATCC 29213 and Escherichia coli ATCC 25922 bacteria were investigated by broth microdilution test. C-AgNPs and essential oil of coriander can be expected to provide future opportunities in nanomedicine and materials science. C-AgNPs can be displayed synergistic antimicrobial effect when used in combination with essential oil.Öğe Urticaria and Angioedema in a Patient Diagnosed with COVID-19: Case Report(Bilimsel Tip Yayinevi, 2021) Akkus, Ilknur; Kaygusuz, SedatCoronavirus disease 2019 (COVID-19) disease caused by the Severe Acute Respiratory Syndrome Coronavirus-2 (SARS-CoV-2) virus, which has affected the whole world, can cause clinical pictures ranging from mild cold symptoms to severe lower respiratory tract infections that can cause mortality. Recently, reports of dermatological findings associated with COVID-19 such as urticaria has been increasing. Here, a COVID-19 case presenting with urticaria and angioedema is described. A 26-year-old female patient, who was found to be SARS-CoV-2 positive by polymerase chain reaction performed for being in contact, presented to our outpatient clinic with complaints of itchy, erythematous lesions on her body and swelling in the eyes and throat for four days. The patient received favipiravir treatment for 5 days and these complaints started 4 days after the treatment ended. History of food and other drug allergies, insect bites and chemicals were questioned in the differential diagnosis for etiology, however, no relationship was detected. Systemic corticosteroid and antihistamine treatment was initiated, and edema in the eyes completely regressed and urticaria plaques faded on the 3rd day of the treatment. Dermatological findings may occur simultaneously with the classic symptoms of the disease or before or after symptoms. Although the pathogenesis between dermatological findings and COVID-19 has not been fully elucidated, studies have suggested that viral infections and SARS-CoV-2 can be an etiological agent for chronic or acute urticaria. It is thought that some rashes may be causally related to the viral effect and others to the immune response. It is emphasized that there may be atypical findings such as urticaria/angioedema in order to diagnose COVID-19 disease early and prevent its spread and should be considered in differential diagnosis.Öğe Investigation of immunity against Bordetella pertussis in pregnant women and an overview of the vaccination schedule in Turkey(Turkish J Pediatrics, 2021) Gül, Serdar; Sönmez, Cemile; Ayvaz, Gökçe; Kılıç, SelçukBackground. Pertussis caused by Bordetella pertussis, is a disease leading to significant morbidity and mortality in neonates and infants. Direct protection of the infant may be achieved by maternal and neonatal vaccination. Despite primary vaccination, infants under six months pose the greatest risk of infection with pertussis. Maternal immunization provides a high level of infant protection from birth until immunity is achieved by active vaccination. There is no routine Tdap vaccination recommendation for pregnant women in Turkey. This study was carried out to determine pertussis antibody levels in pregnant women and provide data for improving vaccine planning. Methods. The study was carried out with 133 pregnant women in Turkey. Antibody titers to pertussis toxin (anti-PT) and filamentous hemagglutinin (anti-FHA) were measured by the commercially available ELISA. Results. Among 133 participants, 93 (69.9%) were found to be immune according to anti-PT IgG antibody levels. According to anti-FHA IgG antibody levels, 123 (92.5%) participants were considered to be immune. A positive correlation was observed between PT and FHA and the findings were statistically significant (P <0.001, r = 0.343). In the study group, the ages of the participants varied between 17 and 44 years. The mean age of those who were immune was 27.3 +/- 5.6, the mean age of non-immune patients was 29.1 +/- 6.2 and the difference was not statistically significant (P= 0.14). Conclusions. Our results reveal that approximately one-third of pregnant women were not immune to pertussis, reflecting many young infants to be vulnerable to pertussis infection until the onset of primary vaccinations, although childhood pertussis vaccination coverage has been high for a long time. We conclude that Tdap vaccine recommendation for pregnant women regardless of previous immunization history may be beneficial for the protection of infants in their first six months.Öğe Idiopathic Hypereosinophilic Syndrome as a Rare Cause of Stroke: A Case Report(Turkish Neurological Soc, 2021) Turğut, Esra; Alpua, Murat; Yalçın, Selim; Coşkun, Oya; Bilgili, Mirace Yasemin Karadeniz; Açıkgöz, Ergin Ayaşlıoğlu; Coşkun, ÖzlemHypereosinophilic syndrome (HES) is a rare hematological disease that causes organ damage by eosinophil infiltration in the tissue with increased eosinophil production in the bone marrow. HES is a rare but important cause of stroke. Central nervous system involvement findings can be serious and life-threatening. Eosinophil values should be examined as the cause of stroke, and hypereosinophilia should be suspected, especially in young patients with no etiology. Reported herein is a case of a 47-year-old female patient who was followed up with the diagnosis of acute cerebrovascular disease due to idiopathic HES.Öğe Clinical Patterns and Seasonal Distribution of Urinary Tract Infection Caused by Extended-spectrum Beta-lactamase-producing Bacteria in Children(Bilimsel Tip Yayinevi, 2021) Tursun, Serkan; Arslan, Zeynep; Alpcan, Ayşegül; Gül, Serdar; Kandur, YaşarIntroduction: Extended-spectrum beta-lactamase-producing Escherichia coli or Klebsiella pneumoniae infections in the pediatric age group are mostly nosocomial infections. This study aimed to investigate the clinical pattern of extended-spectrum beta-lactamase positive urinary tract infection and its seasonal distribution. Materials and Methods: We retrospectively reviewed the medical records of pediatric patients with extended-spectrum beta-lactamases-positive UTI, who were followed-up in our clinic between lune 2015 and lune 2020. Results: One hundred-and-ten patients with ESBL-positive UTI and 231 with non-ESBL UTI were enrolled in this study. The rate of male sex in the ESBL group was significantly lower than that in the non-ESBL group (10.9% vs 27.2%, p= 0.001). The patients with ESBL were older than those in the non-ESBL group (81.3 +/- 49.0 months vs 56.0 +/- 47.2 months, p= 0.001). E. coli was the most iso- lated bacteria in both groups (68% and 70.5%, respectively). The rate of Klebsiella isolation in urine culture was significantly greater in the ESBL group than in the non-ESBL group (p= 0.04). The seasonal distribution of ESBL-positive patients was as follows: spring (18/16.4%), summer (25/22.7%), autumn (25/22.7%), and winter (42/38.2%). Conclusion: There is a substantially high rate of antibiotic resistance among patients with urinary tract infection in developing countries like Turkey. Moreover, we should be aware of the risk of ESBL-positive UTIs, especially in winter.Öğe Nozokomiyal Acinetobacter baumannii İzolatlarında Sulbaktam Duyarlılık Oranlarının E-test Yöntemi ile Belirlenmesi(2017) Temoçin, Fatih; Tülek, Necla; Erdinç, F. Şebnem; Hekimoğlu, Şirin; Demirelli, Meryem; Ertem, Günay; Şahin, HünkarHastane infeksiyonlarına yol açan etkenler arasında Acinetobacter cinsi bakteriler önemli bir yer tutmaktadır. Çoklu ilaç dirençli Acinetobacter infeksiyonları dünyada artan oranlarda görülmektedir. Bu nedenle, terapötik seçenekler sınırlı hale gelmektedir. Duyarlılık oranları net olarak bilinmese de, tek başına sulbaktam veya sulbaktam-ampisilin, Acinetobacter infeksiyonlarının tedavisinde kombinasyonlarda yer almaktadır. Bu çalışmada, çoğul dirençli Acinetobacter baumannii kökenlerinde, sulbaktamın minimum inhibitör konsantrasyonu (MİK) değerleri E-test yöntemi ile incelenmiştir. Materyal ve Metod: Çalışmaya, 15 Haziran 2011-15 Haziran 2013 tarihleri arasında, Sağlık Bakanlığı Ankara Eğitim ve Araştırma Hastanesinde yatan hastalardan alınan klinik örneklerden izole edilen, karbapenem direncini de barındıran çoklu ilaca dirençli 100 A. baumannii kökeni alındı. Antibiyotik duyarlılıkları ve tür düzeyinde tanımlaması konvansiyonel yöntemler ve VITEK 2 (bioMérieux SA, Fransa) sistemi ile yapılmıştır. Üç veya daha fazla ilaç grubuna karşı direnç saptanması çoğul ilaç direnci olarak kabul edildi. Yüz izolat çalışma gününe kadar -80ºC'de gliserollü "brain heart" besiyerinde (Oxoid, UK) saklandı. Kontrol kökeni olarak Escherichia coli ATCC (American Type Culture Collection) 25922 kullanıldı. Sulbaktamın 100 izolata karşı E-test yöntemi ile saptanan MİK değerleri (µg/mL), MİK50 ve MİK90 değerleri (µg/mL) kaydedildi. Tek başına sulbaktamın Acinetobacter'e karşı belirlenmiş bir duyarlılık sınırı olmadığı için, duyarlılık oranları, literatürde rapor edilen MİK sınır değerleri dikkate alınarak hesaplanmıştır (<= 4 µg/mL ve <= 8 µg/mL). Bulgular: Acinetobacter izolatlarına karşı sulbaktam MİK değerleri geniş bir aralıkta dağılmıştı (1 µg/mL ile 256 µg/mL arasında); MİK50 ve MİK90 değerleri ise sırasıyla 12 µg/mL ve 96 µg/mL saptandı. Duyarlılık sınırı 8 µg/mL kabul edildiğinde, izolatların %44'ü duyarlı saptanmışken, sınır 4 µg/mL kabul edildiğinde bu oran %21 ile sınırlı kaldı. Sonuç: Çalışmamızdaki sulbaktam MİK değerleri göz önüne alındığında, çoklu ilaca dirençli A. baumannii tedavisinde sulbaktam umut verici bir ajan olarak görülmektedir. Ancak, özellikle klinik etkinlik konusunda farklı çalışmalara ihtiyaç vardır.Öğe Eklem içi hiyaluronik asit uygulamasından sonra akut aseptik artrit(2017) Kaçmaz, Birgül; Oktaş, Birhan; Tiftikçi, Uğur; Balcı, Mahi; Gül, Serdar; Aslan, AyşegülDiz ekleminde gelişen osteoartrit tedavisinde eklem içi hiyaluronik asit (HA) uygulanabilmektedir. Yan etki genellikle görülmemekle birlikte tekrarlayan uygulamalar sonrasında 24-48. saatte nadiren aseptik artrit gelişebilmektedir. Bu raporda ilk kez diz eklemine HA uygulanan bir hastada, 3-4 saatte gelişen, septik artriti taklit eden akut aseptik artrit olgusu sunulmuşturÖğe A Case of Chylothorax with Interesting Etiology(2018) Ogan, Nalan; Aakpınar, Evrim Eylem; Kaplan, Tevfik; Türker, Gökçe; Gülhan, MeralChylothorax occurs when chylous fluid from the lymphatic system accumulates in the pleural space due to damage to the ductus thoracicus. The milky fluid contains a high concentration of triglycerides in the form of chylomicrons. The initial test for diagnosis is analysis of the pleural fluid. It may be associated with a number of traumatic and nontraumatic conditions. Chylothorax was diagnosed in a patient who underwent an operation for a thoracic vertebra fracture 4 years earlier who presented with bronchitis. Fixation pins in the lower thoracic vertebra inserted in the operation were observed on thorax computerized tomography. No other etiological cause for chylothorax was found based on the patient history, physical examination, or advanced examinations. It was decided that the collapse and fracture operation had a late complication. This case is presented as an interesting etiological cause of chylothorax as, to our knowledge, there is no similar case in the literature.Öğe Kırıkkale Üniversitesi Tıp Fakültesi Hastanesi Polikliniklerine başvuran kişilerde bruselloz seroprevalansı(2004) Apan, Teoman Zafer; Kaygusuz, Sedat; Kılıç, Dilek; Yıldırım, Ayşenur; Aksoy, Altan; Ayaşlıoğlu, ErginBu çalışmanın amacı, Kırıkkale'de bruselloz sıklığını saptamaktır. Kırıkkale Üniversitesi Hastanesi polikliniklerine Haziran 1998-Mayıs 2003 tarihleri arasında değişik nedenlerle başvuran 681 erkek, 1201 kadın hastada Brucella tüp aglütinasyon testi ve Rose Bengal testleriyle bruselloz seroprevalansı araştırıldı. Hastalar cinsiyete ve yaş gruplarına göre sınıflandırıldı. Erkek ve kadın hastalarda, sırasıyla, 20 yaş altında %3.6, %4.3; 20-50 yaş arasında %5.9, %4.2 ve 50 yaş üzerinde %9.6 ve %5.3 seropozitiflik oranı saptandı. Toplam seropozitiflik oranı %5.2 olarak bulundu. Değişik yakınmalarla gelen hastalar arasında bulunan bu %5.2'lik pozitiflik oranı Kırıkkale yöresi için yönlendirici olmalıdır.Öğe Sağlık çalışanlarında tetanoza yaklaşım ve tetanoz antitoksin düzeylerinin belirlenmesi(2001) Kılıç, Dilek; Tülek, Necla; Çavuşoğlu, Turgut; Uçar, Ali Erkan; Yıldırım, Cenap; Tezel, SavaşBu çalışma, hastalık ve korunma yolları konusunda bilinçli olduğu ve bunun gereklerini yerine getirdiği varsayılan sağlık çalışanları arasında tetanoza yaklaşımı ve koruyucu antikor düzeylerini belirlemek amacıyla yapılmıştır. Çalışmaya 53 doktor, 60 hemşire 31 sağlık teknisyeni, ve 30 yardımcı sağlık personeli alınmıştır. Çalışmaya katılanlara bir anket uygulandıktan serum antitoksin düzeyleri ELISA ile ölçülmüştür. Tetanozdan korunma yöntemi olarak en fazla (%55) yara temizliği ve aşılama yanıtı verilmiştir. Çalışmaya alınanların %58'inin son 10 yıl içinde tetanoz aşılarını yaptırdıkları ve bu grubun daha çok doktor ve hemşirelerden oluştuğu saptanmıştır. Kadınlarda aşı olma oranının daha yüksek olduğu, tüm gruplarda yaş ilerledikçe aşı olma oranının azaldığı görülmüştür. Çalışmaya alınanların % 53'ünde tetanoz antitoksin düzeyi 1 IU/ml ve üzerinde, %21'inde ise 0.1 IU/ml'den daha düşük bulunmuştur. Yaş ilerledikçe antitoksin fitresinin düştüğü saptanmıştır. Doktor ve hemşire grubunda tetanoz antikor titre ortalamasının diğerlerinden anlamlı olarak yüksek olduğu bulunmuştur. Sonuç olarak, hastalık konusunda daha bilinçli olmanın daha düzenli aşılamayı ve daha yüksek antitoksin düzeyi ile birlikte daha iyi korunmayı sağladığı, ancak erişkin aşılanmasına daha fazla önem verilmesi gerektiğini göstermektedir.Öğe Aseptik meninjit tablosu ile başvuran bir sistemik lupus eritematozuz(2005) Ayaşlıoğlu, Ergin; Çeken, Sabahat; Kılıç, Dilek; Kaygusuz, Sedat; Erol, Özlem; Küçük, Seda SibelAseptik meninjit, sistemik lupus eritematozuz (SLE)'da nadir görülen klinik bir tablodur. Bu yazıda, aseptik meninjit tablosu ile başvuran bir 22 yaşındaki kadın SLE olgusu sunulmuş, bu tabloya neden olabilecek infeksiyon ve infeksiyon dışı hastalıklar tartışılmıştır.Öğe Üçüncü basamak bir referans hastanesinde izole edilen metisilin dirençli stafilokok suşlarında duyarlılık(2012) Ağalar, Canan; Göçmen, Jülide Sedef; Kılıç, Sultan Dilek; Kaygusuz, Sedat; Karabıçak, ÇiğdemAmaç: Metisiline dirençli stafilokok suşlarının hastane infeksiyonlarında büyük pay sahibi oldukları bilinmektedir. Hastanemizdeki stafilokok suşlarının antimikrobiyal direnç durumlarını bilmek doğru ampirik tedavi başlamak için son derece önemlidir. Gereç ve yöntem: Tersiyer referans hastanesi konumundaki hastanemizde patojen olarak izole edilen stafilokok suşlarının duyarlılığını geriye dönük olarak değerlendirmeyi amaçladık. Kırıkkale Üniversitesi Tıp Fakültesi Enfeksiyon Hastalıkları ve Klinik Mikrobiyoloji Anabilim Dalı laboratuvarında, Kasım 2009-Kasım 2010 tarihleri arasında, hasta örneklerinden etken olarak izole edilen metisiline dirençli 276 stafilokok suşu çalışmaya alındı. Suşların tiplendirimi ve antibiyotiklere duyarlılıkları Vitek (bioMerieux) sisteminde yapıldı. Bulgular: Suşların büyük çoğunluğu kan (%49) ve yara biyopsi materyalinden (%40) izole edildi. Glikopeptidlere dirençli suşa rastlanmamış, suşların linezolide %97’si, eritromisine %16’sı duyarlı bulunmuştur. Sonuç: Bu etkenlerle oluşan infeksiyonların kontrolü ve etkin sağaltımı için sonuçların klinisyenlere bildirilerek özellikle metisilin dirençli stafilokok enfeksiyonlarının tedavisinde uygun ampirik antibiyotik kullanımının sağlanması gerektiğine inanmaktayız.Öğe The Relationship Between Coagulase Producing Time And Methicillin Susceptibility In Staphylococcus Aureus(2015) Gül, SerdarAMAÇ: Koagulaz testi Staphylococcus aureus suşlarının tanımlanmasında ve ayrımında kullanılır. Bu şuşlarda metisilin direnci mortalite ve morbidite ile ilişkili bulunmuştur. Bu çalışmada S. aureus suşlarında metisilin duyarlılığı ve koagulaz üretimi arasındaki ilişki araştırılmıştır. GEREÇ VE YÖNTEMLER: Çalışmaya 108 S. aureus suşu alınmıştır. Suşların 43 tanesi metisilin dirençli ve 65 tanesi metisilin duyarlı idi. Koagulaz üretiminin saptanmasında tüp koagulaz testi kullanılmıştır. Tüpler birinci, ikinci, üçüncü, dördüncü ve 24. saatin sonunda pıhtı oluşumuna göre değerlendirilmiştir.BULGULAR: Sonuçlar üç grupta değerlendirilmiştir. Grup 1: Pıhtı oluşturmayan grup, Grup 2: Zayıf pıhtı oluşturan grup, Grup 3: Güçlü pıhtı oluşturan grup. Birinci ve ikinci saatin sonunda metisilin duyarlılığında grup 2 ve 3 arasında anlamlı bir sonuç bulunamamıştır. Fakat grup2 ve 3 arasında üçüncü saatin sonunda anlamlı bir ilişki saptanmıştır (p=0,036). Grup 3' teki suşların çoğunun metisiline duyarlı olduğu görülmüştür. SONUÇ: Çalışmanın sonuçlarına göre üçüncü saatin sonunda güçlü pıhtı oluşumu, S. aureus suşlarında metisilin duyarlılığı açısından yol gösterici olabilir
