Serum soluble CD30 levels in Behcet's disease
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Tarih
2004
Yazarlar
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
Clinical & Exper Rheumatology
Erişim Hakkı
info:eu-repo/semantics/closedAccess
Özet
Behcet's disease is associated with the inflammatory response. Several reports indicate the presence of primarily CD4+ T cells of the Th1 subtype in the inflammation process of the disease. Serum soluble CD30 (sCD30) is reported to be released from CD4+ Th2 type cells and has been suggested to be a marker of Th2 activity In this study, serum sCD30 levels were measured in active and inactive patients with Behcet's disease, healthy controls and a group of patients with rheumatoid arthritis, typical Th1 disorder using enzyme immunoassay kit. Mean sCD30 value of 54 active patients were found significantly higher than in those of 17 inactive patients (p = 0.027), 20 healthy controls (p = 0.040) and 25 patients with rheumatoid arthritis (p < 0.001). There was a significant correlation between increased sCD30 levels and clinical activity index in active patients with Behcet's disease. High serum levels of sCD30 may reflect the activation of CD4+ T cells or a subset of them in active BD patients. In addition. to serum sCD30 levels, measurements of the Th2 cytokines may be a helpful tool for the evaluation of Th2 activity in Behcet's disease.
Açıklama
Anahtar Kelimeler
soluble CD30; disease activity; Behcet's disease
Kaynak
Clinical and Experimental Rheumatology
WoS Q Değeri
Q3
Scopus Q Değeri
Cilt
22
Sayı
4
