THE EFFECT OF PHOTOTHERAPY TREATMENT ON OXIDATIVE STRESS AND INFLAMMATORY RESPONSE IN NEWBORNS

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dc.contributor.authorAgirtas, Gulsah
dc.contributor.authorGuzoglu, Nilufer
dc.contributor.authorAkbas, Ozgul Tunc
dc.contributor.authorKısa, Üçler
dc.contributor.authorAliefendioglu, Didem
dc.date.accessioned2025-01-21T16:13:35Z
dc.date.available2025-01-21T16:13:35Z
dc.date.issued2023
dc.departmentKırıkkale Üniversitesi
dc.description.abstractObjective: A reason for oxidative stress is photodynamic reactions with phototherapy. It is thought that phototherapy changes cytokine production which leads to different effects on the immune system. The aim of this study is to investigate the effects of light-emitting diode (LED) phototherapy and conventional phototherapy on oxidative stress and inflammatory response in neonatal hyperbilirubinemia. Material and Methods: Thirty-term newborns treated with phototherapy were enrolled on the study group. The study group was divided into LED phototherapy (n=15) and conventional phototherapy (n=15) subgroups. The control group consisted of 30-term healthy newborns. Blood samples were taken before phototherapy, at the 24th hours of phototherapy and after phototherapy treatment. Bilirubin, malonaldehyde (MDA), total oxidative stress (TOS), total antioxidant capacity (TAC), TNF- ?, IL-6 and IL-8 levels were evaluated between groups. Results: There were no significant differences in MDA and TAC in the conventional phototherapy group both before and after phototherapy. However, TOS levels were significantly higher during and after phototherapy than before phototherapy in the conventional phototherapy group. In the same group, IL-8 levels were significantly higher during phototherapy than after phototherapy levels. Whereas, there were no significant differences in oxidative stress and inflammatory response parameters in the LED phototherapy group. Conclusion: While conventional phototherapy increases oxidative stress and acts at some stages of the inflammatory response, there are no effects of LED phototherapy on antioxidant defence systems and inflammatory response.
dc.identifier.doi10.24938/kutfd.1118250
dc.identifier.endpage22
dc.identifier.issn2148-9645
dc.identifier.issue1
dc.identifier.startpage16
dc.identifier.trdizinid1171813
dc.identifier.urihttps://doi.org/10.24938/kutfd.1118250
dc.identifier.urihttps://search.trdizin.gov.tr/tr/yayin/detay/1171813
dc.identifier.urihttps://hdl.handle.net/20.500.12587/21945
dc.identifier.volume25
dc.indekslendigikaynakTR-Dizin
dc.language.isoen
dc.relation.ispartofKırıkkale Üniversitesi Tıp Fakültesi Dergisi
dc.relation.publicationcategoryMakale - Ulusal Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/openAccess
dc.snmzKA_20241229
dc.subjectOptik
dc.subjectGenel ve Dahili Tıp
dc.subjectİmmünoloji
dc.subjectPediatri
dc.titleTHE EFFECT OF PHOTOTHERAPY TREATMENT ON OXIDATIVE STRESS AND INFLAMMATORY RESPONSE IN NEWBORNS
dc.typeArticle

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