Effects of Lonidamine-Loaded Lipid-Polymer Hybrid Nanoparticles on Cardiac Fibrosis Induced By High-Dose Testosterone Propionate In Adult and Neutered Male Rats
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Tarih
2018
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
Erişim Hakkı
info:eu-repo/semantics/openAccess
Özet
In recent years, the usage of exogenous testosterone has tripled in humans. Although, mechanism has not yet been fullyelucidated, there is a correlation between the increased risk of heart failure and testosterone usage. The aim of this studywas to demonstrate cardiac fibrosis, which a main finding of hearth failure, in testosterone propionate-applied male ratsand to show its regression by Lonidamine as an anti-hyperplastic agent. A total of 72 adult Wistar albino and neutralizedmale rats were divided into 4 groups (n=18 in each groups). Animals in all groups were received to testosterone propionateuntil 2nd, 4th, and 12th weeks (n=6 in each groups). Subsequently, group I and II also received the pure solution ofLonidamine hydrochloride and its lipid-polymer hybrid nanoparticulate formulation via intraprostatic injection. Group III,blank lipid-polymer hybrid nanoparticle formulation were solely administrated via same way. The control group or groupIV were received only testosterone. At the end of the experiment period, hearts were collected and fibrocytic changes wereconfirmed by histochemical and immunohistochemical methods. Histopathologically, fibrosis were lower in group I and IIwhen comprared to that of group III and IV. Imunohistochemically, bFGF, cyclin D1 and p16 protein expressions wereevaluated. bFGF and cyclinD1 epxressions correspondingly to increasing fibrosis were found higher in last two groupsduring the experiment. But, p16 expressions were lower in Lonidamine treated-group I and II. In conclusion, results ofthis study supported that testosterone propionate may promote cardiac fibrosis. Lonidamine hydrochloride may be used inits prevention of fibrosis.
Açıklama
Anahtar Kelimeler
Tıbbi Araştırmalar Deneysel, Veterinerlik, Kalp ve Kalp Damar Sistemi
Kaynak
Kocatepe Veterinary Journal
WoS Q Değeri
Scopus Q Değeri
Cilt
11
Sayı
4
