Effects of Lonidamine-Loaded Lipid-Polymer Hybrid Nanoparticles on Cardiac Fibrosis Induced By High-Dose Testosterone Propionate In Adult and Neutered Male Rats

Basit Öğe Kaydı
dc.contributor.authorAlçığır, Mehmet Eray
dc.contributor.authorTürk, Ceyda Tuba Şengel
dc.contributor.authorHasçiçek, Canan
dc.contributor.authorEkim, Okan
dc.date.accessioned2025-01-21T16:19:30Z
dc.date.available2025-01-21T16:19:30Z
dc.date.issued2018
dc.departmentKırıkkale Üniversitesi
dc.description.abstractIn recent years, the usage of exogenous testosterone has tripled in humans. Although, mechanism has not yet been fullyelucidated, there is a correlation between the increased risk of heart failure and testosterone usage. The aim of this studywas to demonstrate cardiac fibrosis, which a main finding of hearth failure, in testosterone propionate-applied male ratsand to show its regression by Lonidamine as an anti-hyperplastic agent. A total of 72 adult Wistar albino and neutralizedmale rats were divided into 4 groups (n=18 in each groups). Animals in all groups were received to testosterone propionateuntil 2nd, 4th, and 12th weeks (n=6 in each groups). Subsequently, group I and II also received the pure solution ofLonidamine hydrochloride and its lipid-polymer hybrid nanoparticulate formulation via intraprostatic injection. Group III,blank lipid-polymer hybrid nanoparticle formulation were solely administrated via same way. The control group or groupIV were received only testosterone. At the end of the experiment period, hearts were collected and fibrocytic changes wereconfirmed by histochemical and immunohistochemical methods. Histopathologically, fibrosis were lower in group I and IIwhen comprared to that of group III and IV. Imunohistochemically, bFGF, cyclin D1 and p16 protein expressions wereevaluated. bFGF and cyclinD1 epxressions correspondingly to increasing fibrosis were found higher in last two groupsduring the experiment. But, p16 expressions were lower in Lonidamine treated-group I and II. In conclusion, results ofthis study supported that testosterone propionate may promote cardiac fibrosis. Lonidamine hydrochloride may be used inits prevention of fibrosis.
dc.identifier.doi10.30607/kvj.437999
dc.identifier.endpage413
dc.identifier.issn1308-1594
dc.identifier.issn2147-6853
dc.identifier.issue4
dc.identifier.startpage402
dc.identifier.trdizinid393639
dc.identifier.urihttps://doi.org/10.30607/kvj.437999
dc.identifier.urihttps://search.trdizin.gov.tr/tr/yayin/detay/393639
dc.identifier.urihttps://hdl.handle.net/20.500.12587/23098
dc.identifier.volume11
dc.indekslendigikaynakTR-Dizin
dc.language.isoen
dc.relation.ispartofKocatepe Veterinary Journal
dc.relation.publicationcategoryMakale - Ulusal Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/openAccess
dc.snmzKA_20241229
dc.subjectTıbbi Araştırmalar Deneysel
dc.subjectVeterinerlik
dc.subjectKalp ve Kalp Damar Sistemi
dc.titleEffects of Lonidamine-Loaded Lipid-Polymer Hybrid Nanoparticles on Cardiac Fibrosis Induced By High-Dose Testosterone Propionate In Adult and Neutered Male Rats
dc.typeArticle

Dosyalar

Koleksiyon

TR-Dizin İndeksli Yayınlar Koleksiyonu