Effect of dexmedetomidine on erythrocyte deformability during ischaemia-reperfusion injury of heart in diabetic rats

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dc.contributor.authorArslan M.
dc.contributor.authorComu F.M
dc.contributor.authorKip G.
dc.contributor.authorAlkan M.
dc.contributor.authorKiraz H.A.
dc.contributor.authorOzer A.
dc.contributor.authorSivgin V.
dc.date.accessioned2020-06-25T15:17:30Z
dc.date.available2020-06-25T15:17:30Z
dc.date.issued2014
dc.departmentKırıkkale Üniversitesi
dc.description.abstractThe aim of this study is to evaluate the effect of dexmedetomidine on erythrocyte deformability during IR heart injury in diabetic rats. Methods: Eighteen Wistar Albino rats were included in the study after streptozocin (55 mg/kg) treatment for four weeks. In the Group C and DC (sham-control group), the coronary artery was not occluded or reperfused in the control rats. In the Group DIR, a branch of the left coronary artery was occluded for 30 minutes followed by two hours of reperfusion to produce IR. In the Group DIRD, a branch of the left coronary artery was occluded for 30 minutes followed by two hours of reperfusion to produce IR, and dexmedetomidine was administrated via 100 ?g/kg IP route 30 minutes before ligating the left coronary artery. Deformability measurements were performed in erythrocyte suspensions containing Htc 5 % in a PBS buffer. Results: The deformability index was signifi cantly increased in diabetic rats; however, it was similar in the Group DC and DIRD. It was signifi cantly increased in the Group DIR when compared to the Group C, DIRD and DC. The relative resistance was increased in IR models. Conclusion: Erythrocyte deformability was decreased in rats having diabetes and IR injury. This injury might lead to further problems in microcirculation. It was shown that dexmedetomidine might be useful in enhancing the adverse effects of this type of injury.en_US
dc.identifier.doi10.4149/BLL_2014_096
dc.identifier.endpage497en_US
dc.identifier.issn00069248
dc.identifier.issue8en_US
dc.identifier.pmid25246286
dc.identifier.scopus2-s2.0-84906960118
dc.identifier.scopusqualityQ2
dc.identifier.startpage494en_US
dc.identifier.urihttps://doi.org/10.4149/BLL_2014_096
dc.identifier.urihttps://hdl.handle.net/20.500.12587/2401
dc.identifier.volume115en_US
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherComenius Universityen_US
dc.relation.ispartofBratislava Medical Journal
dc.relation.publicationcategoryMakale - Ulusal Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectDexmedetomidineen_US
dc.subjectErythrocyte deformabilityen_US
dc.subjectExperimental diabetesen_US
dc.subjectMyocardial ischemia reperfusionen_US
dc.subjectRaten_US
dc.titleEffect of dexmedetomidine on erythrocyte deformability during ischaemia-reperfusion injury of heart in diabetic ratsen_US
dc.typeArticle

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