The protective effects of dexmedetomidine on hepatic ischemia reperfusion injury

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dc.contributor.authorKucuk A.
dc.contributor.authorYaylak F.
dc.contributor.authorCavunt-Bayraktar A.
dc.contributor.authorTosun M.
dc.contributor.authorArslan M.
dc.contributor.authorComu F.M.
dc.contributor.authorKavutcu M.
dc.date.accessioned2020-06-25T15:17:32Z
dc.date.available2020-06-25T15:17:32Z
dc.date.issued2014
dc.departmentKırıkkale Üniversitesi
dc.description.abstractObjective: The aim of this study was to evaluate the effect of dexmedetomidine (100 ?g/kg-ip) on liver ischemia and reperfusion (I/R) in rats. Methods: Twenty-four Wistar Albino rats were separated into three groups as control (C), ischemia-reperfusion injury (I/R) and dexmedetomidine group (I/R-D). Ischemia was induced with portal clampage for 45 minutes and reperfusion period was 45 minutes after declampage. Group I/R-D was received dexmedetomidine 100 ?g/ kg i.p. 30 min before portal clampage. Thiobarbutiric Acid-Reactive Substances (TBARS), glutathioneS-transferase (GST), superoxide dismutase (SOD), Catalase (CAT), and Paraoxonase 1 (PON-1) were investigated in blood samples. Also HSP60 and p53-positive hepatocytes were counted under ImageJ image analysis program. Results: All parameters, except GST levels, were significant between the groups (p < 0.05). Although HSP60 expression was significantly increased between I/R, I/R-D and C groups there were no significant differences between I/R-D and C (p = 0.443). On the other hand, p53 expression was also significantly increased between I/R, I/R-D and C groups At the same time, there were no significant differences between I/R-D and C groups (p = 0.354). Conclusion: All the results suggest that dexmedetomidine has beneficial effects on liver ischemia/reperfusion stress.en_US
dc.identifier.doi10.4149/BLL_2014_132
dc.identifier.endpage684en_US
dc.identifier.issn00069248
dc.identifier.issue11en_US
dc.identifier.pmid25428535
dc.identifier.scopus2-s2.0-84915825911
dc.identifier.scopusqualityQ2
dc.identifier.startpage680en_US
dc.identifier.urihttps://doi.org/10.4149/BLL_2014_132
dc.identifier.urihttps://hdl.handle.net/20.500.12587/2414
dc.identifier.volume115en_US
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherComenius Universityen_US
dc.relation.ispartofBratislava Medical Journal
dc.relation.publicationcategoryMakale - Ulusal Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectDexmedetomidineen_US
dc.subjectHSP60en_US
dc.subjectIschemia reperfusionen_US
dc.subjectp53en_US
dc.subjectRaten_US
dc.titleThe protective effects of dexmedetomidine on hepatic ischemia reperfusion injuryen_US
dc.typeArticle

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