Microwave-assisted synthesis of alginate-g-polyvinylpyrrolidone copolymer and its application in controlled drug release

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dc.contributor.authorYigitoglu, Mustafa
dc.contributor.authorAydin, Gulden
dc.contributor.authorIsiklan, Nuran
dc.date.accessioned2020-06-25T18:12:20Z
dc.date.available2020-06-25T18:12:20Z
dc.date.issued2014
dc.departmentKırıkkale Üniversitesi
dc.description.abstractThe aim of this study is to synthesize graft copolymer (NaAlg-g-PVP) in microwave oven and prepare pH-responsive beads with high entrapment efficiency. For this purpose, PVP was grafted onto sodium alginate using microwave radiation. The copolymer obtained was characterized using FTIR, H-1-NMR, elemental analysis and thermogravimetric analysis. A series of NaAlg-g-PVP beads were prepared as drug delivery matrices for ibuprofen (IB) by cross-linking into beads via glutaraldehyde. The chemical stability of IB after encapsulation into beads was confirmed by FTIR, DSC, and X-RD analysis. Synthesis conditions of beads were optimized by considering entrapment efficiency, particle size, swelling capacity and their release data. Effects of such variables as graft yield and drug/polymer ratio were investigated at 1.2 and 7.4 pH values. Increasing the drug/polymer ratio and extent of cross-linking caused decrease in the IB release. On the other hand, increase in the graft yield led to increase in the IB release as well. The results also showed that NaAlg-g-PVP beads were positive pH-responsive.en_US
dc.description.sponsorshipKirikkale University Scientific Research FoundationKirikkale Universityen_US
dc.description.sponsorshipThe authors are grateful to the Kirikkale University Scientific Research Foundation for financial support.en_US
dc.identifier.citationclosedAccessen_US
dc.identifier.doi10.1007/s00289-013-1067-0
dc.identifier.endpage414en_US
dc.identifier.issn0170-0839
dc.identifier.issn1436-2449
dc.identifier.issue2en_US
dc.identifier.scopus2-s2.0-84893319934
dc.identifier.scopusqualityQ1
dc.identifier.startpage385en_US
dc.identifier.urihttps://doi.org/10.1007/s00289-013-1067-0
dc.identifier.urihttps://hdl.handle.net/20.500.12587/5870
dc.identifier.volume71en_US
dc.identifier.wosWOS:000330826700006
dc.identifier.wosqualityQ3
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.language.isoen
dc.publisherSpringeren_US
dc.relation.ispartofPolymer Bulletin
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectGraft copolymeren_US
dc.subjectControlled releaseen_US
dc.subjectDrug delivery systemsen_US
dc.subjectIbuprofenen_US
dc.subjectHydrophilic polymersen_US
dc.titleMicrowave-assisted synthesis of alginate-g-polyvinylpyrrolidone copolymer and its application in controlled drug releaseen_US
dc.typeArticle

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