Antideprasan İlaçların Etken Maddelerinin Adsorpsiyonu: Kinetik ve İzotermi
[ X ]
Tarih
2017
Yazarlar
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
Kırıkkale Üniversitesi
Erişim Hakkı
info:eu-repo/semantics/openAccess
Özet
Buçalışmada bir önceki çalışmamız elde ettiğimiz yüksek yüzey alana sahip aktifkarbon kullanılarak venlafaxine ve doxylamine antiderprasan ilaçların etkenmaddesinin adsorpsiyonu incelenmiştir. Adsorpsiyon çalışmalarında çözeltibaşlangıç pH, çözelti başlangıç konsantrasyonu ve aktif karbon miktarıparametrelerin etkisi incelenmiştir. Adsorpsiyonun denge verileri Langmuir vefreundlich izotermlerine uygulanmış ve en iyi Langmuir izotermine uyduğubelirlenmiştir. Langmuir izotermine qmax venlafaxine ve doxylamine maddeleriiçin sırasıyla 8.764 ve 10.764 mg/g olduğu tespit edilmiştir. İlaç etkenmaddelerinin adsorpsiyon kinetiği yalancı birinci derece ve yalancı ikinciderece kinetik modeller için hesaplanmış ve en iyi yalancı ikinci derecekinetik model olduğu belirlenmiştir.
In this study, the adsorption of the activeagent of venlafaxine and doxylamine antidepressant drugs was investigated byusing the high surface area active carbon obtained in our previous study. Theeffects of initial pH of solution, initial concentration of solution and amountof activated carbon were examined in adsorption experiments. The adsorptionequilibrium data were applied to the Langmuir and Freundlich isotherms and thebest Langmuir isotherm was determined. Langmuir isotherm was found as 8.764 and10.764 for qmax venlafaxine and doxylamine substances, respectively. Theadsorption kinetics of the drug substance were calculated for pseudo firstorder and pseudo second order kinetic models and it was determined to be thebest pseudo second order kinetic model.
In this study, the adsorption of the activeagent of venlafaxine and doxylamine antidepressant drugs was investigated byusing the high surface area active carbon obtained in our previous study. Theeffects of initial pH of solution, initial concentration of solution and amountof activated carbon were examined in adsorption experiments. The adsorptionequilibrium data were applied to the Langmuir and Freundlich isotherms and thebest Langmuir isotherm was determined. Langmuir isotherm was found as 8.764 and10.764 for qmax venlafaxine and doxylamine substances, respectively. Theadsorption kinetics of the drug substance were calculated for pseudo firstorder and pseudo second order kinetic models and it was determined to be thebest pseudo second order kinetic model.
Açıklama
Anahtar Kelimeler
Antideprasan, ilaç etken maddesi, adsorpsiyon, izoterm, Antidepressant, drug substance, adsorption, isotherm
Kaynak
Uluslararası Mühendislik Araştırma ve Geliştirme Dergisi
WoS Q Değeri
Scopus Q Değeri
Cilt
1
Sayı
1-1
