The efficacy of platelet-rich plasma gel in MRSA-related surgical wound infection treatment: an experimental study in an animal model

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dc.authoridPetrone, Patrizio/0000-0002-7629-1663
dc.authoridMarini, Corrado Paolo/0000-0002-4155-8292
dc.authoridEker, Ibrahim/0000-0002-1880-546X
dc.contributor.authorCetinkaya, R. A.
dc.contributor.authorYilmaz, S.
dc.contributor.authorUnlu, A.
dc.contributor.authorPetrone, P.
dc.contributor.authorMarini, C.
dc.contributor.authorKarabulut, E.
dc.contributor.authorUrkan, M.
dc.date.accessioned2025-01-21T16:45:28Z
dc.date.available2025-01-21T16:45:28Z
dc.date.issued2018
dc.departmentKırıkkale Üniversitesi
dc.description.abstractIntroductionThe wound healing properties of platelet-rich plasma (PRP) gel have been documented in many studies. PRP gel has also become a promising agent for treating surgical site infections. In this study, we investigated the antibacterial activity and wound healing effectiveness of PRP in an animal model of Methicillin-resistant Staphylococcus aureus subsp. aureus (MRSA N315)-contaminated superficial soft tissue wounds.Materials and methodsSubcutaneous wounds in Wistar Albino male rats were created by making two cm midline incisions followed by inoculation of microorganisms. Study groups comprised of Sham (no treatment), PRP alone, MRSA alone, MRSA+PRP, MRSA+Vancomycin, and MRSA+Vancomycin+PRP groups. We inoculated 0.1mL (3x10(8) CFU/mL) of MRSA in contaminated groups. After 8 days, all rats were killed, wounds were excised and subjected to histopathologic examination, and MRSA counts were determined.ResultsMRSA counts in MRSA, MRSA+PRP, MRSA+Vancomycin and MRSA+Vancomycin+PRP groups were 5.1x10(6) (SD0.4) CFU/mL, 4.3x10(6) (SD +/- 0.7) CFU/mL, 2.3x10(6) (SD +/- 0.3) CFU/mL, 1.1x10(6) (SD +/- 0.4) CFU/mL, respectively. The inflammation scores of MRSA+PRP, MRSA+Vancomycin, and MRSA+Vancomycin+PRP groups were significantly lower than the MRSA group. MRSA+Vancomycin+PRP group inflammation score was significantly lower than the MRSA+PRP group.DiscussionAll treatment groups were effective in wound healing and decreasing the MRSA counts. MRSA+PRP combined created identical inflammation scores to the PRP group. More in vivo studies are required to corroborate these findings.
dc.identifier.doi10.1007/s00068-017-0852-0
dc.identifier.endpage867
dc.identifier.issn1863-9933
dc.identifier.issn1863-9941
dc.identifier.issue6
dc.identifier.pmid28965136
dc.identifier.startpage859
dc.identifier.urihttps://doi.org/10.1007/s00068-017-0852-0
dc.identifier.urihttps://hdl.handle.net/20.500.12587/25656
dc.identifier.volume44
dc.identifier.wosWOS:000451419500009
dc.identifier.wosqualityQ2
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherSpringer Heidelberg
dc.relation.ispartofEuropean Journal of Trauma and Emergency Surgery
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.snmzKA_20241229
dc.subjectPRP gel; MRSA; Vancomycin; Soft tissue infections
dc.titleThe efficacy of platelet-rich plasma gel in MRSA-related surgical wound infection treatment: an experimental study in an animal model
dc.typeArticle

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