Design and fabrication of hybrid triple-responsive x-carrageenan-based nanospheres for controlled drug delivery

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dc.contributor.authorGeyik, Gulcan
dc.contributor.authorIsiklan, Nuran
dc.date.accessioned2025-01-21T16:37:20Z
dc.date.available2025-01-21T16:37:20Z
dc.date.issued2021
dc.departmentKırıkkale Üniversitesi
dc.description.abstractIn the last two decades, the utilization of magnetic nanospheres in intelligent polymeric structures have received increased attention of researchers in numerous biomedical applications. Here, hybrid nanostructured triple-responsive magnetic nanospheres (kappa-Car-g-P(AA/DMA)@Fe3O4) containing inorganic iron oxide core (Fe3O4) and organic graft copolymeric shell based on x-carrageenan (kappa-Car) and poly(acrylic acid/dimethylaminoethyl methacrylate) (P(AA/DMA)) were synthesized by microwave induced co-precipitation technique. The structure, size, surface morphology, magnetic property and stability of synthesized kappa-Car-g-P(AA/DMA)@Fe3O4 magnetic nanospheres were characterized using FTIR, UV, XRD, TEM, Zeta-sizer, and VSM. kappa-Car-g-P(AA/DMA)@Fe3O4 nanospheres were loaded with 5-Fluorouracil (5-FU) as an antineoplastic drug, and their 5-FU release behavior was explored in diverse graft yields, pH values, temperatures and in the existence of an alternating magnetic field. The kappa-Car-g-P(AA/DMA)@Fe3O4 nanospheres demonstrated pH-, thermo-, and magnetic field-responsive 5-FU release with good biocompatibility and excellent anticancer activity. In addition, 5-FU release under 50 mT magnetic field reached to 100% within 4 h. This work exhibits that hybrid nanospheres have a triple stimuli-responsive influence, which is of principal importance for the future design and application of multi-functional responsive platforms to develop externally stimulated release of active agents and their healthcare capability.
dc.identifier.doi10.1016/j.ijbiomac.2021.10.007
dc.identifier.endpage715
dc.identifier.issn0141-8130
dc.identifier.issn1879-0003
dc.identifier.pmid34637816
dc.identifier.startpage701
dc.identifier.urihttps://doi.org/10.1016/j.ijbiomac.2021.10.007
dc.identifier.urihttps://hdl.handle.net/20.500.12587/24461
dc.identifier.volume192
dc.identifier.wosWOS:000710184600010
dc.identifier.wosqualityQ1
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherElsevier
dc.relation.ispartofInternational Journal of Biological Macromolecules
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.snmzKA_20241229
dc.subjectx-carrageenan; Stimuli-responsive nanosystem; Poly(dimethylaminoethyl methacrylate); Poly(acrylic acid); Magnetic iron oxide
dc.titleDesign and fabrication of hybrid triple-responsive x-carrageenan-based nanospheres for controlled drug delivery
dc.typeArticle

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