Evaluation of oxidative stress biomarkers in acute mercury intoxication

Basit Öğe Kaydı
dc.contributor.authorDalkiran, Tahir
dc.contributor.authorCarman, Kursat Bora
dc.contributor.authorUnsal, Velid
dc.contributor.authorBelge Kurutas, Ergul
dc.contributor.authorKandur, Yasar
dc.contributor.authorDilber, Cengiz
dc.date.accessioned2025-01-21T16:27:34Z
dc.date.available2025-01-21T16:27:34Z
dc.date.issued2021
dc.departmentKırıkkale Üniversitesi
dc.description.abstractINTRODUCTION: Very few studies have evaluated the association between mercury exposure and oxidative stress in humans, particularly in children. AIM: This is the first report where we aimed to determine the oxidative stress status of children who were accidentally exposed to elemental mercury. MATERIALS AND METHODS: In the present study, the study group was composed of 86 randomly selected children poisoned by mercury; the control group was composed of 78 children who had no history of mercury exposure. At admission, blood samples were collected. Blood superoxide dismutase activity, catalase enzyme activity, and glutathione peroxidase activity were measured by Fridovich, Beutler, and Lawrence Burk methods respectively, and the results were given as U/g Hb. Malondialdehyde level was measured by Ohkawa methods, and the results were given as mmol/ml. RESULTS: Catalase activity was significantly lower in the patient group compared to the control group (1.28±0.62 vs. 3.90±0.86 U/g Hb, p=0.010). In exposed children, SOD activity was significantly higher than the controls (5936±810 vs. 2226±464 U/g Hb, p=0.03), while the GSH-Px activity was significantly lower (13.01±3.21 vs. 34.97±7.32 U/g Hb, p=0.013). The MDA levels of the mercury group were significantly higher than the MDA levels of the control group (2.85±0.84 vs. 2.05±0.79 mmol/ml, p=0.04). CONCLUSIONS: The results of the present study showed that acute mercury poisoning causes an alteration of oxidative stress status in children exposed to elemental mercury. This is an open access article distributed under the terms of the Creative Commons Attribution License (CC BY 4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
dc.identifier.doi10.3897/folmed.63.e56110
dc.identifier.endpage709
dc.identifier.issn1314-2143
dc.identifier.issue5
dc.identifier.pmid35851205
dc.identifier.scopus2-s2.0-85134552333
dc.identifier.scopusqualityQ3
dc.identifier.startpage704
dc.identifier.urihttps://doi.org/10.3897/folmed.63.e56110
dc.identifier.urihttps://hdl.handle.net/20.500.12587/23363
dc.identifier.volume63
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherNLM (Medline)
dc.relation.ispartofFolia medica
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/openAccess
dc.snmzKA_20241229
dc.subjectcatalase; glutathione peroxidase; intoxication; malondialdehyde; mercury; superoxide dismutase
dc.titleEvaluation of oxidative stress biomarkers in acute mercury intoxication
dc.typeArticle

Dosyalar

Koleksiyon

Scopus İndeksli Yayınlar Koleksiyonu
PubMed İndeksli Yayınlar Koleksiyonu