Long-term survival after R0 resection of thymoma

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dc.contributor.authorKoçer B.
dc.contributor.authorKaplan T.
dc.contributor.authorGünal N.
dc.contributor.authorKoçer B.G.
dc.contributor.authorAkkaş Y.
dc.contributor.authorYazkan R.
dc.contributor.authorHan S.
dc.date.accessioned2020-06-25T15:17:57Z
dc.date.available2020-06-25T15:17:57Z
dc.date.issued2018
dc.departmentKırıkkale Üniversitesi
dc.description.abstractBackground: The aim of this study was to evaluate the results of R0 resection of thymoma to identify prognostic factors for long-term outcomes. Methods: Data of 62 patients (28 male, 34 female) with a mean age of 47.26 ± 14.42 years, who underwent R0 resection for thymoma and were followed-up between February 2004 and March 2016, were analyzed retrospectively. Results: Eight patients had a video-assisted thoracoscopic thymectomy and 54 had a transsternal extended thymectomy. During a mean follow-up of 128.67 ± 7.95 months, regional recurrence of thymoma was observed in 9 (14.5%) patients. Overall 5- and 10-year survival rates were 85.36% and 78.20%, respectively. The 5- and 10-year survival rates in patients aged < 50 years were significantly better than in those aged ? 50 years (92% and 72% vs. 88% and 39%, p < 0.0001). The 10-year overall survival of patients in Masaoka stage I and II was better than those in stage III (88.9%, 78.4%, 69.8%, respectively, log-rank p < 0.001). The 10-year survival of patients with World Health Organization histological type A, AB, and B1 thymomas was better than those with type B2 and B3 (log-rank test p < 0.001). In multivariate analysis, age < 50 years (p = 0.001), Masaoka stage (p = 0.006), histological type (p = 0.001), and recurrence (p = 0.04) were independent prognostic factors for survival. Conclusion: Our study indicates that age < 50 years, Masaoka stage, histological type, and recurrence are the determinants of survival in surgically resected cases of thymoma. © The Author(s) 2018.en_US
dc.identifier.doi10.1177/0218492318778634
dc.identifier.endpage466en_US
dc.identifier.issn02184923
dc.identifier.issue6en_US
dc.identifier.pmid29945456
dc.identifier.scopus2-s2.0-85049893928
dc.identifier.scopusqualityQ3
dc.identifier.startpage461en_US
dc.identifier.urihttps://doi.org/10.1177/0218492318778634
dc.identifier.urihttps://hdl.handle.net/20.500.12587/2577
dc.identifier.volume26en_US
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherSAGE Publications Inc.en_US
dc.relation.ispartofAsian Cardiovascular and Thoracic Annals
dc.relation.publicationcategoryMakale - Ulusal Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectAge groupsen_US
dc.subjectlocalen_US
dc.subjectNeoplasm recurrenceen_US
dc.subjectNeoplasm stagingen_US
dc.subjectSurvival rateen_US
dc.subjectThymectomyen_US
dc.subjectThymomaen_US
dc.titleLong-term survival after R0 resection of thymomaen_US
dc.typeArticle

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