Cytotoxic, apoptotic and necrotic effects of starch coated copper nanoparticles on Capan 1 pancreatic cancer cells

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dc.authoridILBASMIS TAMER, SIBEL/0000-0003-0361-7105
dc.authoridTamer, Ugur/0000-0001-9989-6123
dc.authoridEvran, Eylul/0000-0002-6860-1019
dc.authoridBoyaci, Ismail/0000-0003-1333-060X
dc.contributor.authorIlbasmis-Tamer, Sibel
dc.contributor.authorTurk, Mustafa
dc.contributor.authorEvran, Sefika
dc.contributor.authorBoyaci, Ismail Hakki
dc.contributor.authorCiftci, Hakan
dc.contributor.authorTamer, Ugur
dc.date.accessioned2025-01-21T16:37:15Z
dc.date.available2025-01-21T16:37:15Z
dc.date.issued2023
dc.departmentKırıkkale Üniversitesi
dc.description.abstractIn the present study we utilized a green synthesis approach by reduction route with ascorbic acid in the presence of starch as the capping agent. Here we aimed to generate a stable starch coating copper nanoparticles (Cu-SNPs) and to investigate their apoptotic and necrotic effects on Capan 1 pancreatic cancer cell line. The water soluble monodisperse starch-protected zero-valent copper nanoparticles were characterized by transmission electron microscopy, XPS, FTIR analysis. TEM images showed that the presence of metallic copper nanoparticles with anisotrophic morphologies and the sizes of 90% copper nanoparticles were in 50 nm and 80 nm range. Cetyl-trimethylammonium bromide (CTAB) coated copper nanoparticles was also synthesized to compare the stability of starch coating copper nanoparticles. It was also found that copper nanoparticles were significantly protected by starch coating. Cu-SNPs exhibited stronger antimicrobial effects on Staphylocossus and Enterococcus. In vitro cell culture studies demonstrated that Cu-SNPs were not cytotoxic on L929-fibroblasts and Capan 1 pancreatic cancer cell in all concentrations used here (6.25-100 ppm) in different extends. The cytotoxic, necrotic, and apoptotic effects of Cu-SNPs on the Capan 1 pancreatic cancer cell line have been exhibited. Furthermore, the micronucleus test and hemolytic activity test were also performed.
dc.identifier.doi10.1016/j.jddst.2022.104077
dc.identifier.issn1773-2247
dc.identifier.issn2588-8943
dc.identifier.scopus2-s2.0-85143679803
dc.identifier.scopusqualityQ1
dc.identifier.urihttps://doi.org/10.1016/j.jddst.2022.104077
dc.identifier.urihttps://hdl.handle.net/20.500.12587/24440
dc.identifier.volume79
dc.identifier.wosWOS:000982059200001
dc.identifier.wosqualityQ1
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.language.isoen
dc.publisherElsevier
dc.relation.ispartofJournal of Drug Delivery Science and Technology
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.snmzKA_20241229
dc.subjectCopper nanoparticles; Pancreatic cancer; Biosynthesis; Starch
dc.titleCytotoxic, apoptotic and necrotic effects of starch coated copper nanoparticles on Capan 1 pancreatic cancer cells
dc.typeArticle

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