The Effect of Varenicline on The Ovarian Follicle and Hormones, and Endometrial Thickness In An Experimental Model

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dc.contributor.authorBulanik, Murat
dc.contributor.authorSagsoz, Nevin
dc.contributor.authorBakirci, Şükrü
dc.contributor.authorYeral, Mahmut Ilkin
dc.contributor.authorAtasoy, Pinar
dc.contributor.authorBoyunaga, Hakan
dc.date.accessioned2025-01-21T16:28:42Z
dc.date.available2025-01-21T16:28:42Z
dc.date.issued2023
dc.departmentKırıkkale Üniversitesi
dc.description.abstractIt was aimed to evaluate the histological, biochemical, and hormonal changes in the reproduct ive system of varenicline exposed female rats in an experimental model. Forty female rats were randomized into 4 groups. (1) Control group (n = 10); (2) Smoking group (smoking exposure 30 minutes twice a day) (n = 8); (3) Varenicline group (1 ml/kg); (4) Smoking+Varenicline (varenicline treatment (1 ml/kg) after smoking exposure (30 minutes twice a day). After the experiment, ovarian follicle count and endometrial thickness were examined; biochemical hormones-include Anti-mullerian hormone-and free oxygen radical levels were calculated. AMH levels were significantly lower in group 4 than in group 1 (p = 0.049). Group 2 and group 3 were significantly lower than group 1 (p = 0.038, p = 0.045, respectively). There was no statistically significant difference in endometrial thickness and free oxygen radical levels between the groups (p>0.05). We found that varenicline is related to reduced AMH and PRMF levels. The difference in endometrial thickness between the groups was not detected. These findings show that varenicline may harm ovarian functions. © 2023, Yuzuncu Yil Universitesi Tip Fakultesi. All rights reserved.
dc.identifier.doi10.5505/ejm.2023.15045
dc.identifier.endpage831
dc.identifier.issn1301-0883
dc.identifier.issue4
dc.identifier.scopus2-s2.0-85174503755
dc.identifier.scopusqualityQ4
dc.identifier.startpage824
dc.identifier.trdizinid1263566
dc.identifier.urihttps://doi.org/10.5505/ejm.2023.15045
dc.identifier.urihttps://search.trdizin.gov.tr/tr/yayin/detay/1263566
dc.identifier.urihttps://hdl.handle.net/20.500.12587/23616
dc.identifier.volume28
dc.indekslendigikaynakScopus
dc.indekslendigikaynakTR-Dizin
dc.language.isoen
dc.publisherYuzuncu Yil Universitesi Tip Fakultesi
dc.relation.ispartofEastern Journal of Medicine
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/openAccess
dc.snmzKA_20241229
dc.subjectAMH; oxidative stress; primordial follicle; Smoking; varenicline
dc.titleThe Effect of Varenicline on The Ovarian Follicle and Hormones, and Endometrial Thickness In An Experimental Model
dc.typeArticle

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