Oxidative and nitrosative stress in patients with ischemic stroke

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dc.contributor.authorDogan, Ozlem
dc.contributor.authorKisa, Ucler
dc.contributor.authorErdemoglu, Ali Kemal
dc.contributor.authorKacmaz, Murat
dc.contributor.authorCaglayan, Osman
dc.contributor.authorKurku, Huseyin
dc.date.accessioned2020-06-25T18:29:23Z
dc.date.available2020-06-25T18:29:23Z
dc.date.issued2018
dc.departmentKırıkkale Üniversitesi
dc.descriptionKISA, Ucler/0000-0002-8131-6810; Kurku, Huseyin/0000-0002-1083-4151
dc.description.abstractBackground: Oxidative and nitrosative stress is well believed to play a role in the pathogenesis of ischemic stroke. This study aims to evaluate the time course of oxidative and nitrosative stress in ischemic stroke. Methods: In total, 27 healthy individuals, 22 individuals with high risk of ischemic stroke due to hypertension and diabetes mellitus, and 20 patients with acute ischemic stroke hospitalized at the Neurology Department of the Kirikkale University School of Medicine were enrolled in the study. Venous blood was collected at admission (hour 0) and again at hours 24, 48, 72, and 96. Nitric oxide (NO), malondialdehyde (MDA), total oxidative stress (TOS), oxidative stress index (OSI), and total antioxidant status (TAS) were measured and compared among stroke patients and control groups. Results: Blood NO was significantly higher in the patient group at 0, 24, 48, and 72 h compared to the healthy and high-risk control groups, and lower at 96 h than at early times within the patient group (p<0.001). MDA was higher in patients than the healthy control group at all times. Conversely, TOS and OSI were significantly lower in the patient group than the healthy control group at 96 h and the high-risk control group at 72 and 96 h (p <0.05). There was a significant correlation between initial NO (0 h) and duration of hospitalization (r= 0.71; p= 0.0003). Conclusions: These findings suggest a substantial early increase in oxidative and nitrosative stress in ischemic stroke patients during the first 2 days post-admission. However, TOS was lower by days 3-4, likely due to pathological recovery and local/systemic defense systems. The correlation between elevated serum NO during the acute phase of stroke and duration of hospitalization suggests NO as a potentially valuable predictor of ensuing oxidative damage and clinical outcome.en_US
dc.identifier.citationDogan, O., Kisa, U., Erdemoglu, A., Kacmaz, M., Caglayan, O. & Kurku, H. (2018). Oxidative and nitrosative stress in patients with ischemic stroke. Journal of Laboratory Medicine, 42(5), 195-200en_US
dc.identifier.doi10.1515/labmed-2018-0036
dc.identifier.endpage200en_US
dc.identifier.issn2567-9430
dc.identifier.issn2567-9449
dc.identifier.issue5en_US
dc.identifier.startpage195en_US
dc.identifier.urihttps://doi.org/10.1515/labmed-2018-0036
dc.identifier.urihttps://hdl.handle.net/20.500.12587/7289
dc.identifier.volume42en_US
dc.identifier.wosWOS:000448627600006
dc.identifier.wosqualityQ4
dc.indekslendigikaynakWeb of Science
dc.language.isoen
dc.publisherWalter De Gruyter Gmbhen_US
dc.relation.ispartofJournal Of Laboratory Medicine
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectantioxidant statusen_US
dc.subjectischemic strokeen_US
dc.subjectmalondialdehydeen_US
dc.subjectnitric oxideen_US
dc.subjectoxidative stressen_US
dc.subjecttotal oxidative stressen_US
dc.titleOxidative and nitrosative stress in patients with ischemic strokeen_US
dc.typeArticle

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