Effectiveness of Iloprost in the Treatment of Bone Marrow Edema

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dc.contributor.authorTosun, Haci Bayram
dc.contributor.authorUludag, Abuzer
dc.contributor.authorDemir, Sukru
dc.contributor.authorSerbest, Sancar
dc.contributor.authorYasar, Mehmet Mete
dc.contributor.authorOznam, Kadir
dc.date.accessioned2021-01-14T18:10:24Z
dc.date.available2021-01-14T18:10:24Z
dc.date.issued2020
dc.departmentKKÜ
dc.description.abstractBackground and objective Bone marrow edema (BME) is a rare condition caused by insufficient osseous blood supply and may result in severe pain that has adverse effects on patients' life. To date, various conservative treatments have been recommended for the treatment of BME, including analgesics, immobilization of the affected extremity, and iloprost infusion. The aim of this retrospective study was to investigate the effectiveness of parenteral iloprost therapy in the treatment of BME detected in different skeletal locations. Materials and methods This retrospective study included 23 patients (17 men and six women) with BME who were classified as stage I-III according to the Association Research Circulation Osseous (ARCO) classification. BME was localized to the proximal femur in 13 (56.5%), the distal femur in four (17.4%), tarsal bone in four (17.4%), and tibial plateau in two (8.7%) patients. The mean age of the patients was 46.7 years and all the patients were evaluated with the Visual Analog scale (VAS), Functional Mobility Scale (FMS), and MRI. Results A significant improvement was observed in the post-treatment VAS and FMS scores of all patients compared to their pre-treatment scores. Moreover, the edema regressed completely in 60.9% of the patients at three months of MRI control. No serious side effects were observed during the treatment in any of the patients. However, transient side effects including headache, arrhythmia, and flushing were observed in five patients. Conclusion The present study indicated that iloprost therapy is an effective and safe option in the treatment of BME patients, particularly in the reduction of severe pain that has adverse effects on patients' social life, regardless of ARCO staging. Moreover, this therapy could be particularly useful in reducing pain, improving functional recovery, and achieving complete regression of the edema on MRI in ARCO stage I-II patients.en_US
dc.identifier.citationTosun HB, Uludağ A, Demir S, Serbest S, Yasar MM, Öznam K. Effectiveness of Iloprost in the Treatment of Bone Marrow Edema. Cureus. 2020 Sep 20;12(9):e10547.en_US
dc.identifier.doi10.7759/cureus.10547
dc.identifier.issn2168-8184
dc.identifier.issue9en_US
dc.identifier.pmid33101795
dc.identifier.urihttps://doi.org/10.7759/cureus.10547
dc.identifier.urihttps://hdl.handle.net/20.500.12587/12568
dc.identifier.volume12en_US
dc.identifier.wosWOS:000571474000002
dc.identifier.wosqualityN/A
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherCUREUS INCen_US
dc.relation.ispartofCUREUS
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectbone marrow edemaen_US
dc.subjectiloprosten_US
dc.subjecttreatmenten_US
dc.titleEffectiveness of Iloprost in the Treatment of Bone Marrow Edemaen_US
dc.typeArticle

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