How does an additional insulin dose for a high-fat, high-protein breakfast affect glysemic response in adolescents with type 1 diabetes?
| dc.contributor.author | Gumus, Aylin Bayindir | |
| dc.contributor.author | Keser, Alev | |
| dc.contributor.author | Siklar, Zeynep | |
| dc.contributor.author | Berberoglu, Merih | |
| dc.date.accessioned | 2025-01-21T16:41:31Z | |
| dc.date.available | 2025-01-21T16:41:31Z | |
| dc.date.issued | 2023 | |
| dc.department | Kırıkkale Üniversitesi | |
| dc.description.abstract | Objective: In this study, it was aimed to evaluate the effects of an additional insulin dose for high-fat and high-protein meal on blood glucose levels in adolescents with type 1 diabetes.Patients and Methods: This study was single-center, crossover, and randomized. Seven adolescents with type 1 diabetes between the ages of 14 and 17 were given breakfast containing high-fat (45.9% energy) and high-protein (21.9% energy) for two consecutive days, and two different insulin doses were administered. According to the first application dose of carbohydrate/insulin ratio, the second application was given this dose of additional insulin up to 30% in postprandial 180th minute. Blood glucose was monitored for 360 minutes at 30-minute intervals using a continuous glucose monitoring system (CGMS).Results: The average time spent in the target range (TIR) of participants was 30.6 +/- 11.83%, and time spent in hyperglycemia and hypoglycemia (time above range (TAR) and time below range (TBR)) were 67.0 +/- 14.31% and 2.4 +/- 4.89%, respectively. There was no statistically significant difference between the early (0-120th min), late (120-360th min), and total (0-360th min) glycemic responses of the applications (p>0.05). According to CGMS result, mean blood glucose, glycemic variability, and absolute blood glucose difference median and mean absolute deviation (MAD%) were found to be similar after two applications (p>0.05).Conclusion: Insulin dose applications should be individually calculated to prevent delayed-prolonged postprandial hyperglycemia caused by high-fat high - protein intake in adolescents with type 1 diabetes. | |
| dc.description.sponsorship | Ankara University Scientific Researches Projects [18L0241003] | |
| dc.description.sponsorship | Financial Disclosure: This research was funded by Ankara University Scientific Researches Projects (Project No. 18L0241003) . | |
| dc.identifier.doi | 10.5472/marumj.1302393 | |
| dc.identifier.endpage | 248 | |
| dc.identifier.issn | 1309-9469 | |
| dc.identifier.issue | 2 | |
| dc.identifier.scopus | 2-s2.0-85161670611 | |
| dc.identifier.scopusquality | Q4 | |
| dc.identifier.startpage | 242 | |
| dc.identifier.uri | https://doi.org/10.5472/marumj.1302393 | |
| dc.identifier.uri | https://hdl.handle.net/20.500.12587/24899 | |
| dc.identifier.volume | 36 | |
| dc.identifier.wos | WOS:001008168200015 | |
| dc.identifier.wosquality | Q4 | |
| dc.indekslendigikaynak | Web of Science | |
| dc.indekslendigikaynak | Scopus | |
| dc.language.iso | en | |
| dc.publisher | Marmara Univ, Fac Medicine | |
| dc.relation.ispartof | Marmara Medical Journal | |
| dc.relation.publicationcategory | Makale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı | |
| dc.rights | info:eu-repo/semantics/closedAccess | |
| dc.snmz | KA_20241229 | |
| dc.subject | Type 1 diabetes; Preprandial insulin; Fat and protein counting; Meal pattern | |
| dc.title | How does an additional insulin dose for a high-fat, high-protein breakfast affect glysemic response in adolescents with type 1 diabetes? | |
| dc.type | Article |
