The effect of the platelet-rich plasma on osteogenicpotential of the periosteum in an animal bone defect model
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Tarih
2021
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
Erişim Hakkı
info:eu-repo/semantics/openAccess
Özet
Objectives: This study aims to investigate whether plasma-richplasma (PRP) enhances the osteogenic potential of periostealgrafts used to repair bone defects and maintains both histologicallyand biomechanically more durable bone tissue. Materials and methods: A standard bone defect was formed tothe left femurs of 54 Sprague-Dawley rats and three groups wereformed. In the first group (n=18), no periosteal repair was donefor bone defect. In the second group (n=18), periosteal graft tissuewas sutured to cover the defect entirely. In the third group (n=18),before periosteal repair, a 1 mL of PRP fibrin was applied into thebone defect. All femoral specimens were compared histologicallyat four and six weeks and biomechanically by three-pointbending test at six weeks after treatment. Results: In the PRP applied group, healing of the bone defectat four weeks was significantly better than the other groups interms of histological new bone formation (p<0.05). At six weeks,new bone formation in both of the periosteum preserved groupswas superior to the first group (p<0.05, for both). There was nostatistically significant difference between the second and thirdgroups at the end of the sixth week in the biomechanical analysis,although both groups were significantly stronger than the firstgroup (p<0.05). Conclusion: Stimulation of the periosteum with PRP applicationcauses early osteogenic differentiation of precursor cells.Although, at biomechanical basis, PRP application does notcreate any significant difference, in the recovery of the bonedefects at very early period, application of PRP may play a role toaccelerate fracture healing and to decrease nonunions.
Açıklama
Anahtar Kelimeler
Cerrahi, Ortopedi
Kaynak
Joint diseases and related surgery
WoS Q Değeri
Scopus Q Değeri
Cilt
32
Sayı
3
