Minimum inhibitory concentration values and problematic disk break points of tigecycline against vancomycin and/or high-level aminoglycoside-resistant enterococci

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dc.contributor.authorIseri, Latife
dc.contributor.authorSahin, Esra
dc.contributor.authorDolapci, Istar
dc.contributor.authorYuruken, Zehra
dc.date.accessioned2020-06-25T18:16:28Z
dc.date.available2020-06-25T18:16:28Z
dc.date.issued2016
dc.departmentKırıkkale Üniversitesi
dc.descriptionDolapci, Istar/0000-0002-6443-4612
dc.description.abstractBackground: Tigecycline is a new, semisynthetic glycylcycline. It is active against important multidrug resistant pathogens. Aim: The purpose of this study was to investigate the sensitivity of multidrug-resistant enterococci to tigecycline, and to test the correlation between the minimal inhibitory concentration (MIC) and disk diffusion methods. Materials and methods: The antimicrobial sensitivity of 108 multidrug-resistant isolates, which included 52 vancomycin-resistant enterococci (VRE) and 56 high-level aminoglycoside-resistant (HLAR) enterococci, was tested by the E test, broth microdilution test and disk diffusion methods. Results: All of the isolates were sensitive to tigecycline, as determined by the E test and broth microdilution test. The MIC 90 value (0.19 mu g/mL) of tigecycline for HLAR enterococci was higher than that for VRE (0.094 mu g/mL). When results were evaluated according to species, the MIC values of tigecycline for Enterococcus faecalis were higher than those for the other species. Eleven (10.1%) isolates produced false resistance results (zone diameter 615 mm) by the disk diffusion method. These cases were classified as major errors. Eight (7.4%) isolates had intermediate sensitivity (sensitivity zone of 16 or 17 mm), which were classified as minor errors. The major and minor error percentages of HLAR enterococci (14.2% major, 10.7% minor error) were higher than those of VRE (5.7% major, 3.8% minor error). These results indicate that tigecycline is effective against multidrug-resistant enterococci. The sensitivity of multidrug-resistant enterococci to tigecycline should be investigated by MIC methods. The disk diffusion method causes major errors, especially for HLAR enterococci. (C) 2015 The Authors. Alexandria University Faculty of Medicine. Production and hosting by Elsevier B.V.en_US
dc.description.sponsorshipKirikkale University Scientific Research UnitKirikkale Universityen_US
dc.description.sponsorshipThis study was supported by Kirikkale University Scientific Research Unit.en_US
dc.identifier.citationLatife İşeri, Esra Şahin, İştar Dolapçı & Zehra Yürüken (2016) Minimum inhibitory concentration values and problematic disk break points of tigecycline against vancomycin and/or high-level aminoglycoside-resistant enterococci, Alexandria Journal of Medicine, 52:2, 125-129.en_US
dc.identifier.doi10.1016/j.ajme.2015.07.004
dc.identifier.endpage129en_US
dc.identifier.issn2090-5068
dc.identifier.issn2090-5076
dc.identifier.issue2en_US
dc.identifier.startpage125en_US
dc.identifier.urihttps://doi.org/10.1016/j.ajme.2015.07.004
dc.identifier.urihttps://hdl.handle.net/20.500.12587/6539
dc.identifier.volume52en_US
dc.identifier.wosWOS:000390144800004
dc.identifier.wosqualityN/A
dc.indekslendigikaynakWeb of Science
dc.language.isoen
dc.publisherElsevier Sci Ltden_US
dc.relation.ispartofAlexandria Journal Of Medicine
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectTigecyclineen_US
dc.subjectVancomycin resistanten_US
dc.subjectEnterococcien_US
dc.subjectHigh-level aminoglycosidesen_US
dc.titleMinimum inhibitory concentration values and problematic disk break points of tigecycline against vancomycin and/or high-level aminoglycoside-resistant enterococcien_US
dc.typeArticle

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