Leukocyte telomere length and lipid parameters in patients with myocardial infarction with non-obstructive coronary arteries

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dc.authoridINANDIKLIOGLU, NIHAL/0000-0001-7137-3929
dc.contributor.authorInandiklioglu, Nihal
dc.contributor.authorDemir, Vahit
dc.contributor.authorCelik, Yunus
dc.contributor.authorDemirtas, Mustafa
dc.date.accessioned2025-01-21T16:42:20Z
dc.date.available2025-01-21T16:42:20Z
dc.date.issued2021
dc.departmentKırıkkale Üniversitesi
dc.description.abstractMyocardial infarction with non-obstructive coronary arteries (MINOCA) is defined as stenosis of less than 50% or no stenosis on coronary angiography in a patient diagnosed with myocardial infarction. Telomere length is expressed by studies that it acts as a biomarker, especially for biological aging and cardiovascular diseases. In this study, we aimed to investigate whether there is a relationship between circulating leukocyte telomere length (LTL) and serum lipid values in MINOCA patients. Forty-five newly diagnosed patients with MINOCA were included in the study, along with 45 healthy controls who matched the patients in terms of age and gender. We determined the LTL value using the RT-PCR method. As a result of the study, we found LTL (p< 0.001) and serum lipid values (HDL-cholesterol (p< 0.001), LDL-cholesterol (p< 0.001), triglycerides (p< 0.05), and total cholesterol (p< 0.05)) to be significantly higher in the MINOCA group than in the control group. When the correlation relationship between LTL and lipid values in the MINOCA group was evaluated, a negative correlation was determined only between LTL and HDL (p=0.014, r=-0.362). This is the first study to evaluate telomere length in MINOCA patients in Turkey. Our results support the existence of short telomere length in MINOCA patients.
dc.description.sponsorshipYozgat Bozok University Project Coordination Application and Research Center [6602a-TF/19-305]
dc.description.sponsorshipWe would like to thank Yozgat Bozok University Project Coordination Application and Research Center for supporting this research (project no: 6602a-TF/19-305) .
dc.identifier.doi10.14715/cmb/2021.67.6.45
dc.identifier.endpage352
dc.identifier.issn0145-5680
dc.identifier.issn1165-158X
dc.identifier.issue6
dc.identifier.pmid35818177
dc.identifier.startpage346
dc.identifier.urihttps://doi.org/10.14715/cmb/2021.67.6.45
dc.identifier.urihttps://hdl.handle.net/20.500.12587/25057
dc.identifier.volume67
dc.identifier.wosWOS:000767355500044
dc.identifier.wosqualityQ4
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherC M B Assoc
dc.relation.ispartofCellular and Molecular Biology
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/openAccess
dc.snmzKA_20241229
dc.subjectAcute Coroner Syndrome; Lipids; MINOCA; Telomere length
dc.titleLeukocyte telomere length and lipid parameters in patients with myocardial infarction with non-obstructive coronary arteries
dc.typeArticle

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