The Genoprotective Effect Of Crocus Sativus L. (Saffron) Extract On Doxorubicin-Induced Genotoxicity In Drosophila Melanogaster

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dc.contributor.authorOz, Selda
dc.contributor.authorArica, Sukran Cakir
dc.date.accessioned2020-06-25T18:34:33Z
dc.date.available2020-06-25T18:34:33Z
dc.date.issued2019
dc.departmentKırıkkale Üniversitesi
dc.description.abstractCrocus sativus L. (saffron) is a medicinal plant that has been used for the prevention and treatment of various diseases since ancient times. Saffron also has a distinctive aroma and is used as a food coloring, in addition to its therapeutic effects. In this study the genotoxic and antigenotoxic impacts of saffron were evaluated using the somatic mutation and recombination test (SMART). Doxorubicin, a chemotherapeutic drug, was used as a genotoxic agent to evaluate the antigenotoxic activity of saffron. Transheterozygous larvae obtained from a standard cross between flare WO and multiple wing hair (mwh) mutant strains of Drosophila melanogaster were treated with the test materials. Saffron extract was applied at three different concentrations (1,5 and 10 mg/mL) to evaluate any genotoxic effect. In the antigenotoxic assessment, each dose of the saffron extract was co-administered with doxorubicin (0.125 mg/mL). The data obtained from our study indicated that the ethanol extract of saffron did not show any genotoxic effect but instead exerted a powerful protective effect against the genotoxic effect of doxorubicin that was dose dependent.en_US
dc.description.sponsorshipCoordination Unit for Kirikkale University Scientific Research Projects [2012/010]en_US
dc.description.sponsorshipThis work was supported by the Coordination Unit for Kirikkale University Scientific Research Projects (Project number: 2012/010).en_US
dc.identifier.citationclosedAccessen_US
dc.identifier.endpage2552en_US
dc.identifier.issn1018-4619
dc.identifier.issn1610-2304
dc.identifier.issue4en_US
dc.identifier.startpage2545en_US
dc.identifier.urihttps://hdl.handle.net/20.500.12587/7953
dc.identifier.volume28en_US
dc.identifier.wosWOS:000465645700024
dc.identifier.wosqualityQ4
dc.indekslendigikaynakWeb of Science
dc.language.isoen
dc.publisherParlar Scientific Publications (P S P)en_US
dc.relation.ispartofFresenius Environmental Bulletin
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectAntigenotoxicityen_US
dc.subjectdoxorubicinen_US
dc.subjectDrosophila melanogasteren_US
dc.subjectmutationen_US
dc.subjectsaffronen_US
dc.subjectSMART assayen_US
dc.titleThe Genoprotective Effect Of Crocus Sativus L. (Saffron) Extract On Doxorubicin-Induced Genotoxicity In Drosophila Melanogasteren_US
dc.typeArticle

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