Phosphorus-nitrogen compounds. Part 36. Syntheses, Langmuir-Blodgett thin films and biological activities of spiro-bino-spiro trimeric phosphazenes
dc.contributor.author | Asmafiliz, Nuran | |
dc.contributor.author | Kilic, Zeynel | |
dc.contributor.author | Civan, Mehmet | |
dc.contributor.author | Avci, Orhan | |
dc.contributor.author | Gonder, L. Yasemin | |
dc.contributor.author | Acik, Leyla | |
dc.contributor.author | Hokelek, Tuncer | |
dc.date.accessioned | 2020-06-25T18:17:07Z | |
dc.date.available | 2020-06-25T18:17:07Z | |
dc.date.issued | 2016 | |
dc.department | Kırıkkale Üniversitesi | |
dc.description | Hokelek, Tuncer/0000-0002-8602-4382; Aydin, Betul/0000-0002-9092-1350; Asmafiliz, Nuran/0000-0002-9335-4101 | |
dc.description.abstract | The condensation reactions of hexachlorocyclotriphosphazene (N3P3Cl6, trimer) with the symmetric N2N2 or N2O2 donor type tetradentate bulky ligands (1-4) gave partly substituted spiro-bino-spiro (sbs) (5-8) trimeric phosphazenes. Compounds 5-8 reacted with pyrrolidine, morpholine and 1,4-dioxa-8-azaspiro[4,5]decane (DASD) to give octapyrrolidino-(9-12), morpholino-(13-16) and DASD-substituted cyclotriphosphazenes (17-20). The structures of the phosphazenes have been elucidated using FTIR, MS, H-1, C-13{H-1} and P-31{H-1} NMR, and HSQC spectral data. The molecular and solid-state structures of 5, 6 and 12 were verified by single crystal X-ray diffraction techniques. On the other hand, the ultrathin and highly ordered Langmuir-Blodgett (LB) films of compounds 6, 7, 9 and 12 were also fabricated. The structural characterization of the LB films was made using p-polarized grazing angle (GAIR) and horizontal attenuated total reflectance (HATR) techniques. All the novel phosphazene derivatives were evaluated for antibacterial activities against Gram-positive (G+) and Gram-negative (G-) bacteria and for antifungal activities against yeast strains. In addition, the cytotoxic effects of compounds 9, 13, 15, 16, 19 and 20 were investigated against L929 fibroblast and MDA-MB-231 breast cancer cells. The most active one among these compounds was compound 9 at 6.25 mu g mL(-1) concentration. The interactions between compounds 5-20 and pBR322 plasmid DNA were determined by agarose gel electrophoresis. | en_US |
dc.description.sponsorship | Turkish Academy of Sciences (TUBA)Turkish Academy of Sciences; Hacettepe University, Scientific Research UnitHacettepe University [013D04602004] | en_US |
dc.description.sponsorship | Z. K. thanks the Turkish Academy of Sciences (TUBA) for partial support of this work. M. C. and T. H. acknowledge the financial support of this work by Hacettepe University, Scientific Research Unit (Grant No: 013D04602004). | en_US |
dc.identifier.citation | closedAccess | en_US |
dc.identifier.doi | 10.1039/c6nj02052f | |
dc.identifier.endpage | 9626 | en_US |
dc.identifier.issn | 1144-0546 | |
dc.identifier.issn | 1369-9261 | |
dc.identifier.issue | 11 | en_US |
dc.identifier.scopus | 2-s2.0-84993967418 | |
dc.identifier.scopusquality | Q2 | |
dc.identifier.startpage | 9609 | en_US |
dc.identifier.uri | https://doi.org/10.1039/c6nj02052f | |
dc.identifier.uri | https://hdl.handle.net/20.500.12587/6697 | |
dc.identifier.volume | 40 | en_US |
dc.identifier.wos | WOS:000387621500073 | |
dc.identifier.wosquality | Q2 | |
dc.indekslendigikaynak | Web of Science | |
dc.indekslendigikaynak | Scopus | |
dc.language.iso | en | |
dc.publisher | Royal Soc Chemistry | en_US |
dc.relation.ispartof | New Journal Of Chemistry | |
dc.relation.publicationcategory | Makale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı | en_US |
dc.rights | info:eu-repo/semantics/closedAccess | en_US |
dc.title | Phosphorus-nitrogen compounds. Part 36. Syntheses, Langmuir-Blodgett thin films and biological activities of spiro-bino-spiro trimeric phosphazenes | en_US |
dc.type | Article |
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