Glucose determination based on a two component self-assembled monolayer functionalized surfaceenhanced Raman spectroscopy (SERS) probe

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dc.contributor.authorTorul, Hilal
dc.contributor.authorCiftci, Hakan
dc.contributor.authorDudak, Fahriye Ceyda
dc.contributor.authorAdiguzel, Yekbun
dc.contributor.authorKulah, Haluk
dc.contributor.authorBoyaci, Ismail Hakki
dc.contributor.authorTamer, Ugur
dc.date.accessioned2020-06-25T18:12:33Z
dc.date.available2020-06-25T18:12:33Z
dc.date.issued2014
dc.departmentKırıkkale Üniversitesi
dc.descriptionDudak, Fahriye Ceyda/0000-0003-4998-0460; Tamer, Ugur/0000-0001-9989-6123
dc.description.abstractIn this report, we present a new detection method for blood glucose, using gold nanorod SERS, a surface enhanced Raman scattering probe embedded in two component self-assembled monolayers (SAMs). Gold nanorod particles and a gold coated slide surface were modified with the two component SAMs consisting of 3-mercaptophenylboronic acid (3-MBA) and 1-decanethiol (1-DT). The immobilization of 3-MBA/1-DT surface-functionalized gold nanoparticles onto 3-MBA/1-DT modified gold-coated slide surfaces was achieved by the cooperation of hydrophobic forces. Two component SAM functionalized substrates were used as SERS probes, by means of the boronic acid and the alkyl spacer functional groups that serve as the molecular recognition and penetration agents, respectively. The SERS platform surface was characterized by cyclic voltammetry, contact angle measurements, AFM (atomic force microscopy) and Raman spectroscopy. Optimum values of the parameters such as pH, time and (3-MBA/1-DT) molar ratio were also examined for the glucose determination. The analytical performance was evaluated and linear calibration graphs were obtained in the glucose concentration range of 2-16 mM, which is also in the range of the blood glucose levels, and the detection limit was found to be 0.5 mM. As a result, the SERS platform was also used for the determination of glucose in plasma samples.en_US
dc.description.sponsorshipScientific and Technological Research Council of Turkey (TUBITAK)Turkiye Bilimsel ve Teknolojik Arastirma Kurumu (TUBITAK) [Cost MP 1205-111T983]en_US
dc.description.sponsorshipThe authors acknowledge The Scientific and Technological Research Council of Turkey (TUBITAK) with the project number Cost MP 1205-111T983 for funding. The authors would like to thank Prof. Nihal Aydogan and Hande Unsal (Hacettepe University, Department of Chemical Engineering, Turkey) for AFM measurements.en_US
dc.identifier.citationBu makale açık erişimli değildir.en_US
dc.identifier.doi10.1039/c4ay00559g
dc.identifier.endpage5104en_US
dc.identifier.issn1759-9660
dc.identifier.issn1759-9679
dc.identifier.issue14en_US
dc.identifier.scopus2-s2.0-84903650421
dc.identifier.scopusqualityQ1
dc.identifier.startpage5097en_US
dc.identifier.urihttps://doi.org/10.1039/c4ay00559g
dc.identifier.urihttps://hdl.handle.net/20.500.12587/5961
dc.identifier.volume6en_US
dc.identifier.wosWOS:000338438500022
dc.identifier.wosqualityQ2
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.language.isoen
dc.publisherRoyal Soc Chemistryen_US
dc.relation.ispartofAnalytical Methods
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.titleGlucose determination based on a two component self-assembled monolayer functionalized surfaceenhanced Raman spectroscopy (SERS) probeen_US
dc.typeArticle

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